Gene Symbol: djlC
Description: J domain-containing HscC co-chaperone; Hsc56
Alias: ECK0642, JW0644, hscD, ybeV
Species: Escherichia coli str. K-12 substr. MG1655
Itoh T, Matsuda H, Mori H. Phylogenetic analysis of the third hsp70 homolog in Escherichia coli; a novel member of the Hsc66 subfamily and its possible co-chaperone. DNA Res. 1999;6:299-305 pubmed
..A further database search revealed that two dnaJ homologs, ybeS and ybeV, were located on the opposite strand near hscC. Consequently, E...
Yoshimune K, Yoshimura T, Nakayama T, Nishino T, Esaki N. Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli. Biochem Biophys Res Commun. 2002;293:1389-95 pubmed
..coli MC4100 strain. We cloned the ybeV gene and purified the gene product named Hsc56, a 55,687-Da protein with a J-domain like sequence...
Kluck C, Patzelt H, Genevaux P, Brehmer D, Rist W, Schneider Mergener J, et al
. Structure-function analysis of HscC, the Escherichia coli member of a novel subfamily of specialized Hsp70 chaperones. J Biol Chem. 2002;277:41060-9 pubmed
..The HscC ATPase was not affected by the nucleotide exchange factor of DnaK GrpE and stimulated 8-fold by DjlC, a DnaJ protein with a putative transmembrane domain, but not by other DnaJ proteins tested...
Hennessy F, Nicoll W, Zimmermann R, Cheetham M, Blatch G. Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions. Protein Sci. 2005;14:1697-709 pubmed
..We also propose a model in which the J domain is able to integrate specificity and chaperone activity. ..
Qiu X, Shao Y, Miao S, Wang L. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell Mol Life Sci. 2006;63:2560-70 pubmed
..This review highlights the progress in studying the domains in DnaJ/Hsp40 proteins, introduces the mechanisms by which they interact with Hsp70s, and stresses their functional diversity. ..
Genevaux P, Georgopoulos C, Kelley W. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. Mol Microbiol. 2007;66:840-57 pubmed
..In particular, recent advances in structure determination have led to significant insights of the underlying complexities and functional elegance of the Hsp70 chaperone machine. ..