Genomes and Genes
Gene Symbol: dhnA
Description: fructose-bisphosphate aldolase class I
Alias: ECK2090, JW5344, dhnA
Species: Escherichia coli str. K-12 substr. MG1655
- Baldwin S, Perham R. Novel kinetic and structural properties of the class-I D-fructose 1,6-bisphosphate aldolase from Escherichia coli (Crookes' strain). Biochem J. 1978;169:643-52 pubmed..In view of its unusual properties, it is unlikely that aldolase 1 from E. coli is closely related to the class-1 aldolases that have been detected in several other prokaryotes, or to the typical class-1 enzymes from eukaryotes. ..
- Singer M, Walter W, Cali B, Rouviere P, Liebke H, Gourse R, et al. Physiological effects of the fructose-1,6-diphosphate aldolase ts8 mutation on stable RNA synthesis in Escherichia coli. J Bacteriol. 1991;173:6249-57 pubmed..This effect is independent of relA and spoT function. Inhibition is dependent upon glucose metabolism past the generation of glucose-6-phosphate; however, the mechanism of this effect is unknown. ..
- Scamuffa M, Caprioli R. Comparison of the mechanisms of two distinct aldolases from Escherichia coli grown on gluconeogenic substrates. Biochim Biophys Acta. 1980;614:583-90 pubmed..The results show that the two enzymes have different mechanisms of action and are consistent with a Schiff-base mechanism for the one which was induced by gluconeogenic substrates and metal-chelate mechanism for the constitutive enzyme. ..
- Peng L, Arauzo Bravo M, Shimizu K. Metabolic flux analysis for a ppc mutant Escherichia coli based on 13C-labelling experiments together with enzyme activity assays and intracellular metabolite measurements. FEMS Microbiol Lett. 2004;235:17-23 pubmed..9% of the carbon flux being channeled via the glyoxylate shunt. However, the flux of the pentose phosphate pathway significantly decreased in the ppc mutant. ..