Gene Symbol: D616_p81016
Description: qacEdelta1
Alias: NR1_p016, qacEdelta1, multidrug exporter
Species: Escherichia coli

Top Publications

  1. Wang M, Tran J, Jacoby G, Zhang Y, Wang F, Hooper D. Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. Antimicrob Agents Chemother. 2003;47:2242-8 pubmed
    ..coli from Shanghai and may contribute to the rapid increase in bacterial resistance to quinolones in China...
  2. Recchia G, Hall R. Gene cassettes: a new class of mobile element. Microbiology. 1995;141 ( Pt 12):3015-27 pubmed
  3. Doi Y, Shibata N, Shibayama K, Kamachi K, Kurokawa H, Yokoyama K, et al. Characterization of a novel plasmid-mediated cephalosporinase (CMY-9) and its genetic environment in an Escherichia coli clinical isolate. Antimicrob Agents Chemother. 2002;46:2427-34 pubmed
    ..bla(CMY-9) was closely located downstream of the end of the common region. These observations are indicative of the exogenous derivation of bla(CMY-9) from some environmental microorganisms such as aeromonads...
  4. Llosa M, Bolland S, de la Cruz F. Structural and functional analysis of the origin of conjugal transfer of the broad-host-range IncW plasmid R388 and comparison with the related IncN plasmid R46. Mol Gen Genet. 1991;226:473-83 pubmed
    ..Conservation of these segments provided independent support for their essential role in oriT function...
  5. Cameron F, Groot Obbink D, Ackerman V, Hall R. Nucleotide sequence of the AAD(2'') aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhfrII in R388. Nucleic Acids Res. 1986;14:8625-35 pubmed
  6. Dubois V, Arpin C, Quentin C, Texier Maugein J, Poirel L, Nordmann P. Decreased susceptibility to cefepime in a clinical strain of Escherichia coli related to plasmid- and integron-encoded OXA-30 beta-lactamase. Antimicrob Agents Chemother. 2003;47:2380-1 pubmed
  7. Bito A, Susani M. Revised analysis of aadA2 gene of plasmid pSa. Antimicrob Agents Chemother. 1994;38:1172-5 pubmed
    ..These deviations are located in the coding region and in the 3' noncoding region. By making deletions in the region for initiation of protein synthesis, we identified a GTG triplet as the most probable start codon for translation. ..
  8. Recchia G, Stokes H, Hall R. Characterisation of specific and secondary recombination sites recognised by the integron DNA integrase. Nucleic Acids Res. 1994;22:2071-8 pubmed
  9. Llosa M, Bolland S, de la Cruz F. Genetic organization of the conjugal DNA processing region of the IncW plasmid R388. J Mol Biol. 1994;235:448-64 pubmed
    ..The conserved features of these three proteins among the different transfer systems suggest that a very widespread conjugal DNA mobilization mechanism is shared by the transfer apparatuses of IncF, IncI, IncP, IncW and Ti plasmids. ..

More Information


  1. Naas T, Mikami Y, Imai T, Poirel L, Nordmann P. Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes. J Bacteriol. 2001;183:235-49 pubmed publisher
    ..Target site duplication at both ends of the transposon indicated that the integron likely was inserted into the plasmid through a transpositional process. This is the first description of an integron located on a composite transposon...
  2. Sabat M, Navarro F, Mir E, Campoy S, Mirelis B, Barb J, et al. Novel complex sul1-type integron in Escherichia coli carrying bla(CTX-M-9). Antimicrob Agents Chemother. 2002;46:2656-61 pubmed
    ..Furthermore, a new insertion sequence, IS3000, has been found in In60. PCR analysis indicates that integron In60 is present in 33 of 34 nonclonal enterobacterial isolates carrying the putative beta-lactamase CTX-M-9...
  3. Sabat M, Tarrag R, Navarro F, Mir E, Verg s C, Barb J, et al. Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain. Antimicrob Agents Chemother. 2000;44:1970-3 pubmed
    ..Outside of this region there are only six amino acids substitutions between both proteins...
  4. Bae I, Lee Y, Lee W, Lee S, Jeong S. Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene. Antimicrob Agents Chemother. 2007;51:3017-9 pubmed publisher
    ..The bla(CTX-M-14) gene was preceded by an ISCR1 element that was followed by a class 1 integron containing three different insert gene cassettes, i.e., dfrA12, orfF, and aadA2...
  5. Parsons Y, Hall R, Stokes H. A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100. Antimicrob Agents Chemother. 1991;35:2436-9 pubmed
    ..The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present...
  6. Jeong J, Yoon H, Kim E, Lee Y, Choi S, Kim N, et al. Detection of qnr in clinical isolates of Escherichia coli from Korea. Antimicrob Agents Chemother. 2005;49:2522-4 pubmed publisher
    ..Transfer of the qnr determinant by conjugation could be detected from only one strain...
  7. Rabel C, Grahn A, Lurz R, Lanka E. The VirB4 family of proposed traffic nucleoside triphosphatases: common motifs in plasmid RP4 TrbE are essential for conjugation and phage adsorption. J Bacteriol. 2003;185:1045-58 pubmed
  8. Partridge S, Brown H, Hall R. Characterization and movement of the class 1 integron known as Tn2521 and Tn1405. Antimicrob Agents Chemother. 2002;46:1288-94 pubmed
    ..The Tn1405 isolate studied was found to represent only the cassette array of In33, which had replaced the cassette array in the recipient plasmid R388, probably by homologous recombination...
  9. Rivas S, Bolland S, Cabez n E, Go i F, de la Cruz F. TrwD, a protein encoded by the IncW plasmid R388, displays an ATP hydrolase activity essential for bacterial conjugation. J Biol Chem. 1997;272:25583-90 pubmed
    ..Furthermore, the dominant character of this mutation suggested that GST-TrwD(K432Q) was still able to interact either with itself or with other component(s) of the conjugative machinery...
  10. Poirel L, Naas T, Guibert M, Chaibi E, Labia R, Nordmann P. Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene. Antimicrob Agents Chemother. 1999;43:573-81 pubmed
    ..Furthermore, blaVEB-1 is encoded on a large (> 100-kb) transferable plasmid found in a Klebsiella pneumoniae MG-2 isolated at the same time from the same patient, indicating a horizontal gene transfer...
  11. Valentine C, Heinrich M, Chissoe S, Roe B. DNA sequence of direct repeats of the sulI gene of plasmid pSa. Plasmid. 1994;32:222-7 pubmed
    ..Our sequenced regions have been assigned GenBank Accession Nos. UO4277 and UO4278 for the first and second sulI genes of pSa, respectively. ..
  12. Scoulica E, Neonakis I, Gikas A, Tselentis Y. Spread of bla(VIM-1)-producing E. coli in a university hospital in Greece. Genetic analysis of the integron carrying the bla(VIM-1) metallo-beta-lactamase gene. Diagn Microbiol Infect Dis. 2004;48:167-72 pubmed publisher
    ..Spread of carbapenem resistance genes among Enterobacteriaceae in hospital is a matter of great concern...
  13. Hall R, Stokes H. The structure of a partial duplication in the integron of plasmid pDGO100. Plasmid. 1990;23:76-9 pubmed
    ..This finding suggests that the 59-base element may have been involved in the event which gave rise to the partial duplication. ..
  14. Swift G, McCarthy B, Heffron F. DNA sequence of a plasmid-encoded dihydrofolate reductase. Mol Gen Genet. 1981;181:441-7 pubmed
    ..2 kb fragment. One of these regions encodes a 78 amino acid polypeptide homologous to another drug-resistant DHFR. The second region essential for DHFR expression appears to be the promoter of the DHFR gene. ..
  15. Sundstrom L, Radstrom P, Swedberg G, Skold O. Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21. Mol Gen Genet. 1988;213:191-201 pubmed
    ..Similar structures were found at the 3' ends of the antibiotic resistance genes in Tn7, which could indicate similar recombination mechanisms to be effective in the evolutionary construction of all these different resistance elements. ..