Gene Symbol: cysA
Description: sulfate/thiosulfate transporter subunit
Alias: ECK2417, JW2415
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Brun Y, Breton R, Lanouette P, Lapointe J. Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. J Mol Biol. 1990;214:825-43 pubmed
    ..4 kb-ptsH greater than -0.05 kb-pstI greater than -0.05 kb-crr greater than -cysM-cysA in the clockwise order (greater than and less than indicate the direction of transcription; kb, 10(3) bases)...
  2. Matijasevic Z, Hajec L, Volkert M. Anaerobic induction of the alkylation-inducible Escherichia coli aidB gene involves genes of the cysteine biosynthetic pathway. J Bacteriol. 1992;174:2043-6 pubmed
    ..This pathway requires a functional cysA operon, which encodes sulfate permease. Mutations in cysA block this pathway of aidB induction...
  3. Sirko A, Hryniewicz M, Hulanicka D, Bock A. Sulfate and thiosulfate transport in Escherichia coli K-12: nucleotide sequence and expression of the cysTWAM gene cluster. J Bacteriol. 1990;172:3351-7 pubmed
    ..Four open reading frames, designated cysT, cysW, cysA, and cysM, have been identified...
  4. Sirko A, Zatyka M, Hulanicka M. Identification of the Escherichia coli cysM gene encoding O-acetylserine sulphydrylase B by cloning with mini-Mu-lac containing a plasmid replicon. J Gen Microbiol. 1987;133:2719-25 pubmed
    ..Enzyme assays on transformants carrying the cloned fragments indicated the presence in the latter of the cysA and cysM genes coding for sulphate permease and O-acetylserine sulphydrylase B, respectively.
  5. Sirko A, Zatyka M, Sadowy E, Hulanicka D. Sulfate and thiosulfate transport in Escherichia coli K-12: evidence for a functional overlapping of sulfate- and thiosulfate-binding proteins. J Bacteriol. 1995;177:4134-6 pubmed
    ..transported by an ABC-type transporter consisting of both the membrane components (the products of cysT, cysW, and cysA genes) and the periplasmic binders (the products of cysP and sbp genes)...
  6. Fuentes D, Fuentes E, Castro M, Perez J, Araya M, Chasteen T, et al. Cysteine metabolism-related genes and bacterial resistance to potassium tellurite. J Bacteriol. 2007;189:8953-60 pubmed
    ..Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium...
  7. Giffard P, Booth I. The rpoA341 allele of Escherichia coli specifically impairs the transcription of a group of positively-regulated operons. Mol Gen Genet. 1988;214:148-52 pubmed
    ..These three systems, the melAB operon, the cysA locus and the ara regulon, are apparently unrelated other than by their requirement for a regulon-specific positive ..
  8. B bien M, Kirsch J, M jean V, Verm glio A. Involvement of a putative molybdenum enzyme in the reduction of selenate by Escherichia coli. Microbiology. 2002;148:3865-72 pubmed publisher
    ..In addition, all the various mutants were still able to reduce selenite into elemental selenium. This implies that the transport and reduction of this compound are clearly distinct from those of selenate...
  9. Brun Y, Lapointe J. Locations of genes in the 52-minute region on the physical map of Escherichia coli K-12. J Bacteriol. 1990;172:4746-7 pubmed

More Information


  1. Hryniewicz M, Sirko A, PaƂucha A, Bock A, Hulanicka D. Sulfate and thiosulfate transport in Escherichia coli K-12: identification of a gene encoding a novel protein involved in thiosulfate binding. J Bacteriol. 1990;172:3358-66 pubmed
    ..Preliminary sequence data from the corresponding region of the Salmonella typhimurium chromosome showed strictly homologous counterparts of the E. coli cysP and cysT genes. ..
  2. Akiyama Y, Shirai Y, Ito K. Involvement of FtsH in protein assembly into and through the membrane. II. Dominant mutations affecting FtsH functions. J Biol Chem. 1994;269:5225-9 pubmed
    ..It was suggested that the amino-terminal membrane region of FtsH interacts with other component(s), and that the two putative ATP binding sites are of vital importance for the FtsH functions. ..
  3. Rosen B, Liu Z. Transport pathways for arsenic and selenium: a minireview. Environ Int. 2009;35:512-5 pubmed publisher
    ..In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification. ..
  4. Saffen D, Presper K, Doering T, Roseman S. Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI, and crr genes. J Biol Chem. 1987;262:16241-53 pubmed
    Specialized lambda-transducing phages that carry the Escherichia coli genes ptsH, ptsI, crr, cysM, and cysA have been isolated, and the genes were subcloned in plasmid pBR322...
  5. Springer S, Huber R. Sulfate and selenate uptake and transport in wild and in two selenate-tolerant strains of Escherichia coli K-12. Arch Biochem Biophys. 1973;156:595-603 pubmed