Gene Symbol: CTX-M-15
Description: hypothetical protein
Species: Escherichia coli

Top Publications

  1. Rejiba S, Mercuri P, Power P, Kechrid A. Emergence and dominance of CTX-M-15 extended spectrum beta-lactamase among Escherichia coli isolates from children. Microb Drug Resist. 2011;17:135-40 pubmed publisher
    ..coli isolates from children in Tunisia. ..
  2. Gangoue Pieboji J, Miriagou V, Vourli S, Tzelepi E, Ngassam P, Tzouvelekis L. Emergence of CTX-M-15-producing enterobacteria in Cameroon and characterization of a blaCTX-M-15-carrying element. Antimicrob Agents Chemother. 2005;49:441-3 pubmed publisher
    ..A truncated form of this element in the second plasmid was identified...
  3. Xu L, Evans J, Ling T, Nye K, Hawkey P. Rapid genotyping of CTX-M extended-spectrum beta-lactamases by denaturing high-performance liquid chromatography. Antimicrob Agents Chemother. 2007;51:1446-54 pubmed publisher
  4. Woodford N, Ward M, Kaufmann M, Turton J, Fagan E, James D, et al. Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK. J Antimicrob Chemother. 2004;54:735-43 pubmed publisher
    ..Because of the public health implications, including for the treatment of community-acquired urinary tract infections, the spread of these strains--and CTX-M-15 beta-lactamase in particular--merits close monitoring...
  5. Mir E, Mirelis B, Navarro F, Rivera A, Mesa R, Roig M, et al. Surveillance of extended-spectrum beta-lactamases from clinical samples and faecal carriers in Barcelona, Spain. J Antimicrob Chemother. 2005;56:1152-5 pubmed publisher
    ..The different types of ESBLs found were similar in both contexts. The most prevalent ESBLs were the CTX-M-related enzymes, with nine different types, followed by SHV-12...
  6. Barth l my M, P duzzi J, Bernard H, Tancr de C, Labia R. Close amino acid sequence relationship between the new plasmid-mediated extended-spectrum beta-lactamase MEN-1 and chromosomally encoded enzymes of Klebsiella oxytoca. Biochim Biophys Acta. 1992;1122:15-22 pubmed
    ..Therefore, MEN-1 is the first transferable extended-spectrum beta-lactamase which is not directly derived from the widespread TEMs or SHV-1 penicillinases with which it presents less than 39% identity...
  7. Bauernfeind A, Stemplinger I, Jungwirth R, Ernst S, Casellas J. Sequences of beta-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases. Antimicrob Agents Chemother. 1996;40:509-13 pubmed
    ..5% for CTX-M-1/MEN-1 and 77.9% for CTX-M-2). The cefotaximases CTX-M-1/MEN-1 and CTX-M-2 represent two members of a new subgroup of plasmidic class A beta-lactamases...
  8. Sonnevend A, Al Dhaheri K, Mag T, Herpay M, Kolodziejek J, Nowotny N, et al. CTX-M-15-producing multidrug-resistant enteroaggregative Escherichia coli in the United Arab Emirates. Clin Microbiol Infect. 2006;12:582-5 pubmed publisher
    ..This is the first detailed description and characterisation of ESBL production in enteroaggregative E. coli and also the first report of CTX-M-producing organisms encountered on the Arabian Peninsula...
  9. He D, Chiou J, Zeng Z, Liu L, Chen X, Zeng L, et al. Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid β-Lactamases Derived from CTX-M-14 and CTX-M-15. Antimicrob Agents Chemother. 2015;59:5976-83 pubmed publisher
    ..These data indicate that residues distal to the active site of CTX-Ms contributed to their enhanced catalytic activities to ESCs. ..

More Information


  1. Naseer U, Nat s O, Haldorsen B, Bue B, Grundt H, Walsh T, et al. Nosocomial outbreak of CTX-M-15-producing E. coli in Norway. APMIS. 2007;115:120-6 pubmed publisher
    ..The outbreak emphasises the epidemic potential of multiple-antibiotic-resistant CTX-M-15-producing E. coli also in a country with low antibiotic usage and low prevalence of antimicrobial resistance...
  2. Karim A, Poirel L, Nagarajan S, Nordmann P. Plasmid-mediated extended-spectrum beta-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1. FEMS Microbiol Lett. 2001;201:237-41 pubmed
    ..The location of ISEcp1 upstream of plasmid-mediated CTX-M-type beta-lactamase genes may contribute to their spread or/and their expression...
  3. Oliver A, P rez D az J, Coque T, Baquero F, Cant n R. Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain. Antimicrob Agents Chemother. 2001;45:616-20 pubmed publisher
    ..The amino acid sequence identity between this enzyme, designated CTX-M-10, and the chromosomal beta-lactamase of Kluyvera ascorbata was 81%...
  4. Matsumoto Y, Ikeda F, Kamimura T, Yokota Y, Mine Y. Novel plasmid-mediated beta-lactamase from Escherichia coli that inactivates oxyimino-cephalosporins. Antimicrob Agents Chemother. 1988;32:1243-6 pubmed
    ..A conjugation study revealed that FEC-1 was encoded by a 74-megadalton plasmid, pFCX1. This may be the first instance of a plasmid-mediated oxyimino-cephalosporinase from E. coli...
  5. Cartelle M, del Mar Tomas M, Molina F, Moure R, Villanueva R, Bou G. High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution. Antimicrob Agents Chemother. 2004;48:2308-13 pubmed publisher
    ..Moreover, by site-directed mutagenesis we demonstrated that this replacement is a key event in ceftazidime hydrolysis..
  6. Saladin M, Cao V, Lambert T, Donay J, Herrmann J, Ould Hocine Z, et al. Diversity of CTX-M beta-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals. FEMS Microbiol Lett. 2002;209:161-8 pubmed
    ..We found upstream of some bla(CTX-M) genes, a 266-bp sequence 100% identical to the sequence upstream of the Kluyvera ascorbata beta-lactamase gene, suggesting that this chromosomal enzyme is the progenitor of the CTX-M-2/5 cluster...
  7. An Y, Lee J, Jung H, Sohn S, Lee J, Park K, et al. Crystallization and preliminary X-ray crystallographic analysis of CTX-M-15, an extended-spectrum ?-lactamase conferring worldwide emerging antibiotic resistance. Protein Pept Lett. 2011;18:858-62 pubmed
    ..50, b = 44.23, and c = 116.92 Å. Analysis of the packing density shows that the asymmetric unit probably contains two molecules with a solvent content of 41.26%. ..
  8. Clermont O, Lavollay M, Vimont S, Deschamps C, Forestier C, Branger C, et al. The CTX-M-15-producing Escherichia coli diffusing clone belongs to a highly virulent B2 phylogenetic subgroup. J Antimicrob Chemother. 2008;61:1024-8 pubmed publisher
    ..coli diffusing clone is associated with a high level of antibiotic resistance and with high virulence, showing that, under certain selective pressures, the previously observed trade-off between resistance and virulence may not apply...