Gene Symbol: cspG
Description: cold shock protein homolog, cold-inducible
Alias: ECK0980, JW0974, cspI
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Xia B, Ke H, Inouye M. Acquirement of cold sensitivity by quadruple deletion of the cspA family and its suppression by PNPase S1 domain in Escherichia coli. Mol Microbiol. 2001;40:179-88 pubmed
    Escherichia coli contains a large CspA family, CspA to CspI. Here, we demonstrate that E...
  2. Nakaminami K, Karlson D, Imai R. Functional conservation of cold shock domains in bacteria and higher plants. Proc Natl Acad Sci U S A. 2006;103:10122-7 pubmed
    ..coli CSPs. Constitutive expression of WT WCSP1 in an E. coli cspA, cspB, cspE, cspG quadruple deletion mutant complemented its cold-sensitive phenotype, suggesting that WCSP1 shares a function with E...
  3. Etchegaray J, Inouye M. CspA, CspB, and CspG, major cold shock proteins of Escherichia coli, are induced at low temperature under conditions that completely block protein synthesis. J Bacteriol. 1999;181:1827-30 pubmed
    CspA, CspB, and CspG, the major cold shock proteins of Escherichia coli, are dramatically induced upon temperature downshift...
  4. El Sharoud W, Graumann P. Cold shock proteins aid coupling of transcription and translation in bacteria. Sci Prog. 2007;90:15-27 pubmed
    ..Members of both protein families have recently been shown to interact, suggesting that a two-step process achieves the coupling process, removal of secondary mRNA structures through CSHs and prevention of reformation through CSPs. ..
  5. Verbenko V, Kuznetsova L, Luchkina L, Klonov N. [Mutation in the cspH-cspG gene cluster enhances expression of heat-shock proteins and SOS repair system of Escherichia coli]. Genetika. 2009;45:1194-202 pubmed
    ..The mutation gamr12 was located at 22.68 min of the chromosomal map in the region of cspH-cspG gene cluster of cold-shock proteins...
  6. Nakashima K, Kanamaru K, Mizuno T, Horikoshi K. A novel member of the cspA family of genes that is induced by cold shock in Escherichia coli. J Bacteriol. 1996;178:2994-7 pubmed
    ..Here we identified a gene that encodes a cold-shock-inducible analog of CspA and CspB. This newly cloned cspG gene is located at 22 min on the E. coli genetic map, apart from the other cspA family genes...
  7. Phadtare S, Inouye M. Genome-wide transcriptional analysis of the cold shock response in wild-type and cold-sensitive, quadruple-csp-deletion strains of Escherichia coli. J Bacteriol. 2004;186:7007-14 pubmed
    ..The deletion of four csps (cspA, cspB, cspG, and cspE) affected cold shock induction of mostly those genes that are transiently induced in the acclimation ..
  8. Kim J, Park S, Kwak K, Kim Y, Kim J, Song J, et al. Cold shock domain proteins and glycine-rich RNA-binding proteins from Arabidopsis thaliana can promote the cold adaptation process in Escherichia coli. Nucleic Acids Res. 2007;35:506-16 pubmed
    ..Together, these results indicate that CSDPs and GRPs help E.coli grow and survive better during cold shock, and strongly imply that CSDP1 and GRP7 exhibit RNA chaperone activity during the cold adaptation process. ..
  9. Bae W, Jones P, Inouye M. CspA, the major cold shock protein of Escherichia coli, negatively regulates its own gene expression. J Bacteriol. 1997;179:7081-8 pubmed
    ..The production of the CspA homologs CspB and CspG increased, and the duration of their expression was prolonged, suggesting that both CspB and CspG compensate for ..

More Information


  1. Trun N, Johnston D. Folding chromosomes in bacteria: examining the role of Csp proteins and other small nucleic acid-binding proteins. Curr Top Dev Biol. 2003;55:173-201 pubmed
  2. Polissi A, De Laurentis W, Zangrossi S, Briani F, Longhi V, Pesole G, et al. Changes in Escherichia coli transcriptome during acclimatization at low temperature. Res Microbiol. 2003;154:573-80 pubmed
    ..Interestingly, we found that PNPase both negatively and positively modulated the transcript abundance of some of these genes, thus suggesting a complex role of PNPase in controlling cold adaptation. ..
  3. Phadtare S, Zhu L, Uemori T, Mukai H, Kato I, Inouye M. Applications of nucleic acid chaperone activity of CspA and its homologues. J Mol Microbiol Biotechnol. 2009;17:110-7 pubmed publisher
    ..E. coli CspA family consists of nine members, CspA to CspI. CspA and some of its homologues play a critical role in cold acclimation of cells as RNA chaperones by ..