Gene Symbol: cspC
Description: stress protein, member of the CspA-family
Alias: ECK1821, JW1812, msmB
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Phadtare S, Inouye M. Sequence-selective interactions with RNA by CspB, CspC and CspE, members of the CspA family of Escherichia coli. Mol Microbiol. 1999;33:1004-14 pubmed
    ..towards identification of the target genes of Csp proteins, we investigated the RNA binding specificities of CspB, CspC and CspE by an in vitro selection approach (SELEX)...
  2. Bae W, Xia B, Inouye M, Severinov K. Escherichia coli CspA-family RNA chaperones are transcription antiterminators. Proc Natl Acad Sci U S A. 2000;97:7784-9 pubmed
    ..Here we demonstrate that CspA, as well as homologous RNA chaperones CspE and CspC, are transcription antiterminators...
  3. Jones P, Inouye M. The cold-shock response--a hot topic. Mol Microbiol. 1994;11:811-8 pubmed
    ..The major cold-shock protein, CspA, has high sequence similarity with three other E. coli proteins--CspB, CspC, and CspD...
  4. Trun N, Johnston D. Folding chromosomes in bacteria: examining the role of Csp proteins and other small nucleic acid-binding proteins. Curr Top Dev Biol. 2003;55:173-201 pubmed
  5. Phadtare S, Zhu L, Uemori T, Mukai H, Kato I, Inouye M. Applications of nucleic acid chaperone activity of CspA and its homologues. J Mol Microbiol Biotechnol. 2009;17:110-7 pubmed publisher
    ..The low substrate specificity of Csps together with their compatibility with various enzymes and their stability and activity over a broad temperature range makes them ideal candidates to be used for a variety of processes. ..
  6. Lee S, Xie A, Jiang W, Etchegaray J, Jones P, Inouye M. Family of the major cold-shock protein, CspA (CS7.4), of Escherichia coli, whose members show a high sequence similarity with the eukaryotic Y-box binding proteins. Mol Microbiol. 1994;11:833-9 pubmed
    ..coli chromosome and encodes a 71-residue protein with 79% identity to CspA, while the other, cspC, is mapped at 40 min and encodes a 69-residue protein with 70% identity...
  7. Rath D, Jawali N. Loss of expression of cspC, a cold shock family gene, confers a gain of fitness in Escherichia coli K-12 strains. J Bacteriol. 2006;188:6780-5 pubmed
    ..Screening for mutations among common laboratory E. coli strains showed a high degree of genetic diversity in cspC but not in cspA and cspE...
  8. Lenz G, Ron E. Novel interaction between the major bacterial heat shock chaperone (GroESL) and an RNA chaperone (CspC). J Mol Biol. 2014;426:460-6 pubmed publisher
    ..Here we show the involvement of GroESL in another proteolytic process, this of the major RNA chaperone--CspC--that specifically stabilizes the transcripts of several stress-related genes...
  9. Phadtare S, Inouye M. Role of CspC and CspE in regulation of expression of RpoS and UspA, the stress response proteins in Escherichia coli. J Bacteriol. 2001;183:1205-14 pubmed publisher
    ..Two members of this family, CspC and CspE, are constitutively produced at 37 degrees C...

More Information


  1. Shenhar Y, Rasouly A, Biran D, Ron E. Adaptation of Escherichi coli to elevated temperatures involves a change in stability of heat shock gene transcripts. Environ Microbiol. 2009;11:2989-97 pubmed publisher
    ..show that the modulation of stability of mRNAs of heat shock genes is maintained by the cold shock protein C - CspC - previously shown to affect transcript stability of specific genes...
  2. Cohen Or I, Shenhar Y, Biran D, Ron E. CspC regulates rpoS transcript levels and complements hfq deletions. Res Microbiol. 2010;161:694-700 pubmed publisher
    ..The rpoS mRNA is also a substrate of the cold shock protein C (CspC) which stabilizes the transcripts...
  3. Yamanaka K, Mitani T, Ogura T, Niki H, Hiraga S. Cloning, sequencing, and characterization of multicopy suppressors of a mukB mutation in Escherichia coli. Mol Microbiol. 1994;13:301-12 pubmed
    ..To identify proteins interacting with the MukB protein, we isolated three multicopy suppressors (msmA, msmB, and msmC) to the temperature-sensitive colony formation of the mukB106 mutation...
  4. Katz C, Rasouly A, Gur E, Shenhar Y, Biran D, Ron E. Temperature-dependent proteolysis as a control element in Escherichia coli metabolism. Res Microbiol. 2009;160:684-6 pubmed publisher
    ..One important mechanism involves temperature-dependent proteolysis, which constitutes a fast response to temperature shift-ups. Here we discuss the effect of proteolysis on protein synthesis, and the heat shock response. ..
  5. Reid G, Shang H, Hogan J, Lee G, McLuckey S. Gas-phase concentration, purification, and identification of whole proteins from complex mixtures. J Am Chem Soc. 2002;124:7353-62 pubmed
    ..The identification of these proteins illustrates the potential of this "top-down" protein identification approach to reduce the reliance on condensed-phase chemistries and extensive separations for complex protein mixture analysis...
  6. Dai Y, Li L, Roser D, Long S. Detection and identification of low-mass peptides and proteins from solvent suspensions of Escherichia coli by high performance liquid chromatography fractionation and matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom. 1999;13:73-8 pubmed
    ..coli. The methodologies reported here should be very useful in searching for unique biomarkers for bacterial discrimination. ..
  7. Phadtare S, Tadigotla V, Shin W, Sengupta A, Severinov K. Analysis of Escherichia coli global gene expression profiles in response to overexpression and deletion of CspC and CspE. J Bacteriol. 2006;188:2521-7 pubmed
    The Escherichia coli cold shock protein CspA family consists of nine proteins (CspA to CspI), of which two, CspE and CspC, are constitutively produced at 37 degrees C and are involved in regulation of expression of genes encoding stress ..
  8. El Sharoud W, Graumann P. Cold shock proteins aid coupling of transcription and translation in bacteria. Sci Prog. 2007;90:15-27 pubmed
    ..Members of both protein families have recently been shown to interact, suggesting that a two-step process achieves the coupling process, removal of secondary mRNA structures through CSHs and prevention of reformation through CSPs. ..