Gene Symbol: creB
Description: response regulator in two-component regulatory system with CreC
Alias: ECK4390, JW4361, ORF2, yjjE
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Amemura M, Makino K, Shinagawa H, Nakata A. Cross talk to the phosphate regulon of Escherichia coli by PhoM protein: PhoM is a histidine protein kinase and catalyzes phosphorylation of PhoB and PhoM-open reading frame 2. J Bacteriol. 1990;172:6300-7 pubmed
    ..PhoM1206 could also transphosphorylate the product of phoM-orf2, which is structurally homologous to phoB and located immediately upstream of phoM...
  2. Wanner B. Is cross regulation by phosphorylation of two-component response regulator proteins important in bacteria?. J Bacteriol. 1992;174:2053-8 pubmed
  3. Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A. Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli. J Biol Chem. 2005;280:1448-56 pubmed
    ..BaeS, BasS, CreC, CusS, HydH, RstB, YedV, and YfhK), and a total of 34 RRs, including putative RRs (BaeR, BasR, CreB, CusR, HydG, RstA, YedW, YfhA, YgeK, and YhjB), have been suggested to exist in Escherichia coli...
  4. Parkinson J, Kofoid E. Communication modules in bacterial signaling proteins. Annu Rev Genet. 1992;26:71-112 pubmed
  5. Amemura M, Makino K, Shinagawa H, Nakata A. Nucleotide sequence of the phoM region of Escherichia coli: four open reading frames may constitute an operon. J Bacteriol. 1986;168:294-302 pubmed
    ..Four open reading frames (ORFs) were identified in the order ORF1-ORF2-ORF3 (phoM)-ORF4-dye clockwise on the standard E. coli genetic map...
  6. Saier M. Bacterial sensor kinase/response regulator systems: an introduction. Res Microbiol. 1994;145:349-55 pubmed
  7. Zheng Y, Roberts R, Kasif S. Genomic functional annotation using co-evolution profiles of gene clusters. Genome Biol. 2002;3:RESEARCH0060 pubmed
    ..We show that the gene-pair phylogenetic profile is more accurate than the single-gene phylogenetic profiles. ..
  8. Stock J, Stock A, Mottonen J. Signal transduction in bacteria. Nature. 1990;344:395-400 pubmed publisher
    ..This phosphotransfer network couples environmental signals to an array of response elements that control cell motility and regulate gene expression...
  9. Pao G, Saier M. Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. J Mol Evol. 1995;40:136-54 pubmed
    ..Sequence data were correlated with structure/function when such information was available.(ABSTRACT TRUNCATED AT 250 WORDS) ..

More Information


  1. Parkinson J. Signal transduction schemes of bacteria. Cell. 1993;73:857-71 pubmed
  2. Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A. Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J Antimicrob Chemother. 2003;52:576-82 pubmed
    ..Thirteen response regulators out of 32 genes, namely baeR, cheY, cpxR, creB, evgA, fimZ, narL, ompR, rcsB, rstA, yedW, yehT and dcuR, conferred increased beta-lactam resistance...
  3. Cariss S, Tayler A, Avison M. Defining the growth conditions and promoter-proximal DNA sequences required for activation of gene expression by CreBC in Escherichia coli. J Bacteriol. 2008;190:3930-9 pubmed publisher
    ..It also is activated during aerobic growth when fermentation products are being used as carbon sources. CreB and CreC are essential for the activation of cre regulon gene expression, but CreA and CreD, encoded as part of the ..
  4. Gao R, Tao Y, Stock A. System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids. Mol Microbiol. 2008;69:1358-72 pubmed publisher
    ..Weak hetero-pair interactions were also identified between several different RRs, suggesting potential cross-regulation between distinct pathways. ..
  5. Nikel P, Zhu J, San K, Méndez B, Bennett G. Metabolic flux analysis of Escherichia coli creB and arcA mutants reveals shared control of carbon catabolism under microaerobic growth conditions. J Bacteriol. 2009;191:5538-48 pubmed publisher
    ..Strains carrying the creB deletion showed a higher biomass yield on glucose compared to the wild-type strain and its DeltaarcA derivative, ..
  6. Nanchen A, Schicker A, Revelles O, Sauer U. Cyclic AMP-dependent catabolite repression is the dominant control mechanism of metabolic fluxes under glucose limitation in Escherichia coli. J Bacteriol. 2008;190:2323-30 pubmed publisher
    ..of Escherichia coli mutants, we elucidated the relevance of global transcriptional regulation by ArcA, ArcB, Cra, CreB, CreC, Crp, Cya, Fnr, Hns, Mlc, OmpR, and UspA on aerobic glucose catabolism in glucose-limited chemostat cultures ..