Gene Symbol: cbpM
Description: modulator of CbpA co-chaperone
Alias: ECK0990, JW0984, yccD
Species: Escherichia coli str. K-12 substr. MG1655
Ueguchi C, Kakeda M, Yamada H, Mizuno T. An analogue of the DnaJ molecular chaperone in Escherichia coli. Proc Natl Acad Sci U S A. 1994;91:1054-8 pubmed
..These genetic results are interpreted as meaning that the function(s) of CbpA in E. coli is closely related to that of DnaJ. ..
Chintakayala K, Grainger D. A conserved acidic amino acid mediates the interaction between modulators and co-chaperones in enterobacteria. J Mol Biol. 2011;411:313-20 pubmed publisher
..The activity of CbpA is regulated by the "modulator" protein CbpM. Here, we have used a combination of genetics and biochemistry to identify the co-chaperone contact determinant of ..
Yamashino T, Kakeda M, Ueguchi C, Mizuno T. An analogue of the DnaJ molecular chaperone whose expression is controlled by sigma s during the stationary phase and phosphate starvation in Escherichia coli. Mol Microbiol. 1994;13:475-83 pubmed
..e. DNA curvature). From these results, it was suggested that, in contrast to DnaJ, CbpA may function as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. ..
Chae C, Sharma S, Hoskins J, Wickner S. CbpA, a DnaJ homolog, is a DnaK co-chaperone, and its activity is modulated by CbpM. J Biol Chem. 2004;279:33147-53 pubmed
..Purified YccD specifically inhibited both the co-chaperone activity and the DNA binding activity of CbpA, suggesting that YccD modulates the activity of CbpA. We named the product of the yccD gene CbpM for "CbpA modulator."
Bird J, Sharma S, Roshwalb S, Hoskins J, Wickner S. Functional analysis of CbpA, a DnaJ homolog and nucleoid-associated DNA-binding protein. J Biol Chem. 2006;281:34349-56 pubmed
..The DNA binding and co-chaperone activities of CbpA are modulated by CbpM, a small protein that binds specifically to CbpA...
Chenoweth M, Trun N, Wickner S. In vivo modulation of a DnaJ homolog, CbpA, by CbpM. J Bacteriol. 2007;189:3635-8 pubmed
..can function as a cochaperone for the DnaK/Hsp70 chaperone system, and its in vitro activity can be modulated by CbpM. We discovered that CbpM specifically inhibits the in vivo activity of CbpA, preventing it from functioning in cell ..
Chenoweth M, Wickner S. Complex regulation of the DnaJ homolog CbpA by the global regulators sigmaS and Lrp, by the specific inhibitor CbpM, and by the proteolytic degradation of CbpM. J Bacteriol. 2008;190:5153-61 pubmed publisher
..CbpA is encoded in an operon with the gene for CbpM, which is a specific in vivo and in vitro inhibitor of CbpA...