Gene Symbol: cbl
Description: ssuEADCB/tauABCD operon transcriptional activator
Alias: ECK1982, JW1966
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Iwanicka Nowicka R, Hryniewicz M. A new gene, cbl, encoding a member of the LysR family of transcriptional regulators belongs to Escherichia coli cys regulon. Gene. 1995;166:11-7 pubmed
    The cbl (cysB-like) gene has been identified in Escherichia coli. The analysis of the cloned cbl sequence revealed strict homology to an ORF of unknown function found initially in Klebsiella aerogenes [Schwacha and Bender, J. Bacteriol...
  2. van der Ploeg J, Iwanicka Nowicka R, Bykowski T, Hryniewicz M, Leisinger T. The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl. J Biol Chem. 1999;274:29358-65 pubmed
    ..chromosomal ssuE'-lacZ fusion was repressed by sulfate or cystine and depended on the presence of a functional cbl gene, which encodes a LysR-type transcriptional regulator...
  3. van der Ploeg J, Eichhorn E, Leisinger T. Sulfonate-sulfur metabolism and its regulation in Escherichia coli. Arch Microbiol. 2001;176:1-8 pubmed
    ..Expression of the tau and ssu genes requires the LysR-type transcriptional regulatory proteins CysB and Cbl. Synthesis of Cbl itself is under control of the CysB protein, and the CysB protein may therefore be regarded as ..
  4. Bykowski T, van der Ploeg J, Iwanicka Nowicka R, Hryniewicz M. The switch from inorganic to organic sulphur assimilation in Escherichia coli: adenosine 5'-phosphosulphate (APS) as a signalling molecule for sulphate excess. Mol Microbiol. 2002;43:1347-58 pubmed
    ..We demonstrate that, of the two LysR-type regulators involved in expression from the ssu promoter, Cbl acts as a direct and sufficient activator of transcription in vivo and in vitro, whereas CysB downregulates the ..
  5. Stec E, Witkowska Zimny M, Hryniewicz M, Neumann P, Wilkinson A, Brzozowski A, et al. Structural basis of the sulphate starvation response in E. coli: crystal structure and mutational analysis of the cofactor-binding domain of the Cbl transcriptional regulator. J Mol Biol. 2006;364:309-22 pubmed
    b>Cbl is a member of the large family of LysR-type transcriptional regulators (LTTRs) common in bacteria and found also in Archaea and algal chloroplasts...
  6. Stec E, Witkowska M, Hryniewicz M, Brzozowski A, Wilkinson A, Bujacz G. Crystallization and preliminary crystallographic studies of the cofactor-binding domain of the LysR-type transcriptional regulator Cbl from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2004;60:1654-7 pubmed
    b>Cbl (CysB-like protein) is a member of the family of LysR-type transcriptional regulators (LTTRs) and controls genes engaged in sulfur assimilation in Escherichia coli...
  7. Cadieux N, Barekzi N, Bradbeer C. Observations on the calcium dependence and reversibility of cobalamin transport across the outer membrane of Escherichia coli. J Biol Chem. 2007;282:34921-8 pubmed
    The calcium dependence of cobalamin (Cbl) binding to the BtuB protein of Escherichia coli and the reversibility of its function in the transport of Cbl across the outer membrane have been examined...
  8. Fuentes D, Fuentes E, Castro M, Perez J, Araya M, Chasteen T, et al. Cysteine metabolism-related genes and bacterial resistance to potassium tellurite. J Bacteriol. 2007;189:8953-60 pubmed
    ..Results showed that cell tolerance to tellurite correlates with the expression level of the cysteine metabolic genes and that these genes are up-regulated when tellurite is present in the growth medium...
  9. van der Ploeg J, Iwanicka Nowicka R, Kertesz M, Leisinger T, Hryniewicz M. Involvement of CysB and Cbl regulatory proteins in expression of the tauABCD operon and other sulfate starvation-inducible genes in Escherichia coli. J Bacteriol. 1997;179:7671-8 pubmed
    ..In this study, the role of the cbl gene in expression of tauABCD and other ssi genes was investigated...

More Information


  1. Kertesz M. Riding the sulfur cycle--metabolism of sulfonates and sulfate esters in gram-negative bacteria. FEMS Microbiol Rev. 2000;24:135-75 pubmed
    ..Additional regulator proteins required for sulfonate desulfonation have been identified in Escherichia coli (the Cbl protein) and Pseudomonas putida (the AsfR protein)...
  2. Gyaneshwar P, Paliy O, McAuliffe J, Popham D, Jordan M, Kustu S. Sulfur and nitrogen limitation in Escherichia coli K-12: specific homeostatic responses. J Bacteriol. 2005;187:1074-90 pubmed
    ..we confirmed known homeostatic responses to global S limitation, which are controlled by the activators CysB and Cbl, and found that S limitation propagated into methionine metabolism, synthesis of FeS clusters, and oxidative stress...