Gene Symbol: casE
Description: CRISPR RNA precursor cleavage enzyme; CRISP RNA (crRNA) containing Cascade antiviral complex protein
Alias: ECK2751, JW2726, cas6e, cse3, ygcH
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. YOUNG R. Molecular biology. Secret weapon. Science. 2008;321:922-3 pubmed publisher
  2. Brouns S, Jore M, Lundgren M, Westra E, Slijkhuis R, Snijders A, et al. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science. 2008;321:960-4 pubmed publisher
    ..Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense...
  3. Semenova E, Kuznedelov K, Datsenko K, Boudry P, Savitskaya E, Medvedeva S, et al. The Cas6e ribonuclease is not required for interference and adaptation by the E. coli type I-E CRISPR-Cas system. Nucleic Acids Res. 2015;43:6049-61 pubmed publisher
    ..of CRISPR arrays consisting of multiple palindromic repeats and intervening spacers through the function of Cas6e endoribonuclease, which cleaves at specific positions of repeat sequences of the CRISPR array transcript...
  4. Babu M, Beloglazova N, Flick R, Graham C, Skarina T, Nocek B, et al. A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol Microbiol. 2011;79:484-502 pubmed publisher
  5. Jackson R, Golden S, van Erp P, Carter J, Westra E, Brouns S, et al. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science. 2014;345:1473-9 pubmed publisher
    ..The structure of Cascade suggests a mechanism for assembly and provides insights into the mechanisms of target recognition. ..