Gene Symbol: casC
Description: CRISP RNA (crRNA) containing Cascade antiviral complex protein
Alias: ECK2753, JW2728, cas4, cas7, cse4, ygcJ
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. YOUNG R. Molecular biology. Secret weapon. Science. 2008;321:922-3 pubmed publisher
  2. Brouns S, Jore M, Lundgren M, Westra E, Slijkhuis R, Snijders A, et al. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science. 2008;321:960-4 pubmed publisher
    ..Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense...
  3. Jackson R, Golden S, van Erp P, Carter J, Westra E, Brouns S, et al. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science. 2014;345:1473-9 pubmed publisher
    ..The structure of Cascade suggests a mechanism for assembly and provides insights into the mechanisms of target recognition. ..
  4. Babu M, Beloglazova N, Flick R, Graham C, Skarina T, Nocek B, et al. A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol Microbiol. 2011;79:484-502 pubmed publisher
  5. Howard J, Delmas S, Ivancic Bace I, Bolt E. Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein. Biochem J. 2011;439:85-95 pubmed publisher
    ..coli, and the apparently antagonistic roles of Cas3 catalysing RNA-DNA annealing and ATP-dependent helicase unwinding. ..
  6. Mulepati S, Héroux A, Bailey S. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Science. 2014;345:1479-84 pubmed publisher
    ..These studies provide insight into both the assembly and the activity of this complex and suggest a mechanism to enforce fidelity of target binding. ..