Gene Symbol: casB
Description: CRISP RNA (crRNA) containing Cascade antiviral complex protein
Alias: ECK2754, JW2729, cse2, ygcK
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Nam K, Huang Q, Ke A. Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures. FEBS Lett. 2012;586:3956-61 pubmed publisher
    The CRISPR system is an adaptive RNA-based microbial immune system against invasive genetic elements. CasB is an essential protein component in Type I-E Cascade...
  2. Jackson R, Golden S, van Erp P, Carter J, Westra E, Brouns S, et al. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science. 2014;345:1473-9 pubmed publisher
    ..The structure of Cascade suggests a mechanism for assembly and provides insights into the mechanisms of target recognition. ..
  3. Twiss E, Coros A, Tavakoli N, Derbyshire K. Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress. Mol Microbiol. 2005;57:1593-607 pubmed
    ..In summary, this work identifies a collection of proteins that allow the host to modulate transposition in response to cell stress. ..
  4. YOUNG R. Molecular biology. Secret weapon. Science. 2008;321:922-3 pubmed publisher
  5. Brouns S, Jore M, Lundgren M, Westra E, Slijkhuis R, Snijders A, et al. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science. 2008;321:960-4 pubmed publisher
    ..Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense...
  6. Mulepati S, Héroux A, Bailey S. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Science. 2014;345:1479-84 pubmed publisher
    ..These studies provide insight into both the assembly and the activity of this complex and suggest a mechanism to enforce fidelity of target binding. ..