casA

Summary

Gene Symbol: casA
Description: CRISP RNA (crRNA) containing Cascade antiviral complex protein
Alias: ECK2755, JW2730, cse1, ygcL
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Hochstrasser M, Taylor D, Bhat P, Guegler C, Sternberg S, Nogales E, et al. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proc Natl Acad Sci U S A. 2014;111:6618-23 pubmed publisher
    ..Cascade comprises the CasA-E proteins and one crRNA, forming a structure that binds and unwinds dsDNA to form an R loop in which the target ..
  2. Jackson R, Golden S, van Erp P, Carter J, Westra E, Brouns S, et al. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Science. 2014;345:1473-9 pubmed publisher
    ..The structure of Cascade suggests a mechanism for assembly and provides insights into the mechanisms of target recognition. ..
  3. Mulepati S, Héroux A, Bailey S. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Science. 2014;345:1479-84 pubmed publisher
    ..These studies provide insight into both the assembly and the activity of this complex and suggest a mechanism to enforce fidelity of target binding. ..
  4. Baranova N, Nikaido H. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J Bacteriol. 2002;184:4168-76 pubmed
    ..We accordingly propose to rename yegMNOB as mdtABCD (mdt for multidrug transporter). Finally, the expression of two other genes, yicO and ygcL, was shown to be regulated by BaeR, but it is not known if they play any roles in resistance.
  5. YOUNG R. Molecular biology. Secret weapon. Science. 2008;321:922-3 pubmed publisher
  6. Brouns S, Jore M, Lundgren M, Westra E, Slijkhuis R, Snijders A, et al. Small CRISPR RNAs guide antiviral defense in prokaryotes. Science. 2008;321:960-4 pubmed publisher
    ..Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense...