Gene Symbol: cadC
Description: cadBA operon transcriptional activator
Alias: ECK4127, JW4094
Species: Escherichia coli str. K-12 substr. MG1655
Products:     cadC

Top Publications

  1. Watson N, Dunyak D, Rosey E, Slonczewski J, Olson E. Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH. J Bacteriol. 1992;174:530-40 pubmed
    ..Upstream of Pcad is an open reading frame, cadC, consisting of 512 codons...
  2. Eichinger A, Haneburger I, Koller C, Jung K, Skerra A. Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family. Protein Sci. 2011;20:656-69 pubmed publisher
    The membrane-integral transcriptional activator CadC comprises sensory and transcriptional regulatory functions within one polypeptide chain...
  3. Fritz G, Koller C, Burdack K, Tetsch L, Haneburger I, Jung K, et al. Induction kinetics of a conditional pH stress response system in Escherichia coli. J Mol Biol. 2009;393:272-86 pubmed publisher
    ..Furthermore, the analysis puts causal constraints on the precise mechanism of signal transduction via the regulatory protein CadC.
  4. Neely M, Dell C, Olson E. Roles of LysP and CadC in mediating the lysine requirement for acid induction of the Escherichia coli cad operon. J Bacteriol. 1994;176:3278-85 pubmed
    ..The responsible mutation in one of these isolates (EP310) was in cadC, a gene encoding a function necessary for transcriptional activation of cadBA...
  5. Meng S, Bennett G. Regulation of the Escherichia coli cad operon: location of a site required for acid induction. J Bacteriol. 1992;174:2670-8 pubmed
    ..This work defines essential sequences for acid induction of this system involved in neutralization of extracellular acid. ..
  6. Tetsch L, Koller C, Haneburger I, Jung K. The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP. Mol Microbiol. 2008;67:570-83 pubmed
    ..cadBA expression is dependent on CadC, a membrane-integrated transcriptional activator which belongs to the ToxR-like protein family and directly binds ..
  7. Kuper C, Jung K. CadC-mediated activation of the cadBA promoter in Escherichia coli. J Mol Microbiol Biotechnol. 2005;10:26-39 pubmed
    The transcriptional activator CadC in Escherichia coli, a member of the ToxR-like proteins, activates transcription of the cadBA operon encoding the lysine decarboxylase CadA and the lysine-cadaverine antiporter CadB...
  8. Neely M, Olson E. Kinetics of expression of the Escherichia coli cad operon as a function of pH and lysine. J Bacteriol. 1996;178:5522-8 pubmed
    ..The membrane-localized CadC protein is required for activation of this operon under inducing conditions, which include acidic external pH, ..
  9. Dell C, Neely M, Olson E. Altered pH and lysine signalling mutants of cadC, a gene encoding a membrane-bound transcriptional activator of the Escherichia coli cadBA operon. Mol Microbiol. 1994;14:7-16 pubmed
    The Escherichia coli CadC protein is required for activation of cadBA transcription under conditions of low external pH and exogenous lysine...

More Information


  1. Takayama M, Ohyama T, Igarashi K, Kobayashi H. Escherichia coli cad operon functions as a supplier of carbon dioxide. Mol Microbiol. 1994;11:913-8 pubmed
    ..Thus, our present results suggested that the physiological role of the cad operon is to supply carbon dioxide when its internal level is lowered under O2-limiting conditions at a low pH. ..
  2. Tetsch L, Koller C, Dönhöfer A, Jung K. Detection and function of an intramolecular disulfide bond in the pH-responsive CadC of Escherichia coli. BMC Microbiol. 2011;11:74 pubmed publisher
    ..cadBA expression is dependent on CadC, a membrane-integrated transcriptional activator which belongs to the ToxR-like protein family...
  3. Samartzidou H, Delcour A. Excretion of endogenous cadaverine leads to a decrease in porin-mediated outer membrane permeability. J Bacteriol. 1999;181:791-8 pubmed
    ..Finally, the mere expression of cadC, in the absence of cadaverine production, leads to a reduction in the amounts of OmpF and OmpC proteins, which ..
  4. Rowbury R. Regulatory components, including integration host factor, CysB and H-NS, that influence pH responses in Escherichia coli. Lett Appl Microbiol. 1997;24:319-28 pubmed
    ..but also needs Lrp; lysine decarboxylase (CadA) formation at acid pH is controlled quite differently, needing the CadC activator and interaction of lysine/lysine permease; H-NS probably reverses induction by CadC...
  5. Gonzalez O, Kuper C, Jung K, Naval P, Mendoza E. Parameter estimation using Simulated Annealing for S-system models of biochemical networks. Bioinformatics. 2007;23:480-6 pubmed All the necessary programs including the required compiler are described in a document archived with the source code. Supplementary material is available at Bioinformatics online. ..
  6. Buchner S, Schlundt A, Lassak J, Sattler M, Jung K. Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli. J Mol Biol. 2015;427:2548-61 pubmed publisher
    The pH-responsive one-component signaling system CadC in Escherichia coli belongs to the family of ToxR-like proteins, whose members share a conserved modular structure, with an N-terminal cytoplasmic winged helix-turn-helix DNA-binding ..
  7. Casalino M, Latella M, Prosseda G, Colonna B. CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype. Infect Immun. 2003;71:5472-9 pubmed
    ..and its transporter constitute a single operon (cadBA) and are expressed at low pH under the positive control of CadC. This regulator is an inner membrane protein that is able to sense pH variation and to respond by transcriptionally ..
  8. Torres A. The cad locus of Enterobacteriaceae: more than just lysine decarboxylation. Anaerobe. 2009;15:1-6 pubmed publisher
    The cadBA genes are transcribed as a transcriptional operon and activated by CadC in a low pH- and lysine-dependent manner...
  9. Casalino M, Prosseda G, Barbagallo M, Iacobino A, Ceccarini P, Latella M, et al. Interference of the CadC regulator in the arginine-dependent acid resistance system of Shigella and enteroinvasive E. coli. Int J Med Microbiol. 2010;300:289-95 pubmed publisher
    ..encoding lysine decarboxylase (CadA) and a lysine cadaverine antiporter (CadB), is submitted to the control of CadC, a positive activator whose gene maps upstream the operon, and is transcribed independently from the same strand...
  10. Rauschmeier M, Schüppel V, Tetsch L, Jung K. New insights into the interplay between the lysine transporter LysP and the pH sensor CadC in Escherichia coli. J Mol Biol. 2014;426:215-29 pubmed publisher
    ..of the regulatory interplay between the lysine-specific permease LysP and the membrane-integrated pH sensor CadC, which together induce lysine-dependent adaptation of E. coli under acidic stress...