Gene Symbol: bglJ
Description: bgl operon transcriptional activator
Alias: ECK4356, JW5955, yjjR
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Giel M, Desnoyer M, Lopilato J. A mutation in a new gene, bglJ, activates the bgl operon in Escherichia coli K-12. Genetics. 1996;143:627-35 pubmed
    ..The putative protein encoded by the bglJ gene has homolgy to a family of transcriptional activators...
  2. Madhusudan S, Paukner A, Klingen Y, Schnetz K. Independent regulation of H-NS-mediated silencing of the bgl operon at two levels: upstream by BglJ and LeuO and downstream by DnaKJ. Microbiology. 2005;151:3349-59 pubmed
    ..disrupting rpoS and crl were obtained, as well as mutations mapping upstream of the open reading frames of bglJ, leuO and dnaK. In rpoS and crl mutants, bgl promoter activity is known to be higher...
  3. Stratmann T, Pul U, Wurm R, Wagner R, Schnetz K. RcsB-BglJ activates the Escherichia coli leuO gene, encoding an H-NS antagonist and pleiotropic regulator of virulence determinants. Mol Microbiol. 2012;83:1109-23 pubmed publisher
    ..Here, we show that the heterodimer of the FixJ/NarL-type transcription regulators RcsB and BglJ strongly activates expression of leuO and that RcsB-BglJ regulates additional loci...
  4. Stratmann T, Madhusudan S, Schnetz K. Regulation of the yjjQ-bglJ operon, encoding LuxR-type transcription factors, and the divergent yjjP gene by H-NS and LeuO. J Bacteriol. 2008;190:926-35 pubmed
    The yjjQ and bglJ genes encode LuxR-type transcription factors conserved in several enterobacterial species. YjjQ is a potential virulence factor in avian pathogenic Escherichia coli...
  5. Venkatesh G, Kembou Koungni F, Paukner A, Stratmann T, Blissenbach B, Schnetz K. BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl operon by H-NS. J Bacteriol. 2010;192:6456-64 pubmed publisher
    ..b>BglJ is a transcriptional regulator whose constitutive expression causes activation of the H-NS- and StpA-repressed bgl (..
  6. Salscheider S, Jahn A, Schnetz K. Transcriptional regulation by BglJ-RcsB, a pleiotropic heteromeric activator in Escherichia coli. Nucleic Acids Res. 2014;42:2999-3008 pubmed publisher
    ..RcsB is unique, as its set of target loci is modulated by interaction with auxiliary regulators including BglJ. The BglJ-RcsB heteromer is known to activate the HNS repressed leuO and bgl loci independent of RcsB ..
  7. Ueguchi C, Ohta T, Seto C, Suzuki T, Mizuno T. The leuO gene product has a latent ability to relieve bgl silencing in Escherichia coli. J Bacteriol. 1998;180:190-3 pubmed
    ..the phenotype of Bgl+, were localized in three loci on the genetic map, two of which appeared to be hns and bglJ, which were previously implicated as the factors affecting the Bgl phenotype...
  8. Ohta T, Ueguchi C, Mizuno T. rpoS function is essential for bgl silencing caused by C-terminally truncated H-NS in Escherichia coli. J Bacteriol. 1999;181:6278-83 pubmed
    ..Among these loci, three appeared to be leuO, hns, and bglJ, which were previously characterized, while the other two were novel...
  9. Breddermann H, Schnetz K. Correlation of Antagonistic Regulation of leuO Transcription with the Cellular Levels of BglJ-RcsB and LeuO in Escherichia coli. Front Cell Infect Microbiol. 2016;6:106 pubmed Escherichia coli leuO is antagonistically regulated by the heterodimeric transcription regulator BglJ-RcsB and by LeuO. BglJ-RcsB activates leuO, while LeuO inhibits activation by BglJ-RcsB...