Gene Symbol: bcr
Description: bicyclomycin/cysteine/sulfonamide efflux transporter
Alias: ECK2176, JW5363, bicA, bicR, sur, suxA
Species: Escherichia coli str. K-12 substr. MG1655
Hirata T, Saito A, Nishino K, Tamura N, Yamaguchi A. Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936). Antimicrob Agents Chemother. 2004;48:2179-84 pubmed
..efflux transporter genes, tet(B), tet(C), and tet(K), and multidrug transporter genes, acrAB, acrEF, and bcr, was examined...
Bentley J, Hyatt L, Ainley K, Parish J, Herbert R, White G. Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance. Gene. 1993;127:117-20 pubmed
..This ORF contains the BcR gene...
Saidijam M, Bettaney K, Szakonyi G, Psakis G, Shibayama K, Suzuki S, et al
. Active membrane transport and receptor proteins from bacteria. Biochem Soc Trans. 2005;33:867-72 pubmed
Hayashi M, Tabata K, Yagasaki M, Yonetani Y. Effect of multidrug-efflux transporter genes on dipeptide resistance and overproduction in Escherichia coli. FEMS Microbiol Lett. 2010;304:12-9 pubmed publisher
..The four genes (bcr, norE, ydeE and yeeO) were selected from 34 genes encoding a multidrug-efflux transporter of E...
Vedantam G, Guay G, Austria N, Doktor S, Nichols B. Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli. Antimicrob Agents Chemother. 1998;42:88-93 pubmed
..coli. Additional characterization of an amplified secondary resistance determinant, sur, present in one of the strains, identified it as the previously identified bicyclomycin resistance determinant bcr, ..
Yamada S, Awano N, Inubushi K, Maeda E, Nakamori S, Nishino K, et al
. Effect of drug transporter genes on cysteine export and overproduction in Escherichia coli. Appl Environ Microbiol. 2006;72:4735-42 pubmed
..coli on L-cysteine export and overproduction. Overexpression of the acrD, acrEF, bcr, cusA, emrAB, emrKY, ybjYZ, and yojIH genes reversed the growth inhibition of tnaA (the major CD gene)-disrupted E...
Nichols B, Guay G. Gene amplification contributes to sulfonamide resistance in Escherichia coli. Antimicrob Agents Chemother. 1989;33:2042-8 pubmed
..The amplified DNA contained a gene designated sur that contributed to sulfathiazole resistance when present in greater amounts than those in the wild type...
Paulsen I, Skurray R. Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes--an analysis. Gene. 1993;124:1-11 pubmed
..The conservation of these motifs suggested that they may be essential for the function of these proteins. Phylogenetic and structural analysis revealed that the two families may have evolved from a common ancestor with six TMS. ..
Henderson P, Hoyle C, Ward A. Expression, purification and properties of multidrug efflux proteins. Biochem Soc Trans. 2000;28:513-7 pubmed
..In addition, ligands for efflux proteins labelled with (13)C or (15)N have been synthesized to implement solid-state NMR studies of the ligand-binding site. ..