Gene Symbol: bacA
Description: undecaprenyl pyrophosphate phosphatase
Alias: ECK3047, JW3029, uppP
Species: Escherichia coli str. K-12 substr. MG1655
El Ghachi M, Bouhss A, Blanot D, Mengin Lecreulx D. The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity. J Biol Chem. 2004;279:30106-13 pubmed publisher
..This is the first gene encoding undecaprenyl pyrophosphate phosphatase identified to date. Considering its newly identified function, we propose to rename the bacA gene uppP.
El Ghachi M, Derbise A, Bouhss A, Mengin Lecreulx D. Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli. J Biol Chem. 2005;280:18689-95 pubmed
The bacA gene product of Escherichia coli was recently purified to near homogeneity and identified as an undecaprenyl pyrophosphate phosphatase activity (El Ghachi, M., Bouhss, A., Blanot, D., and Mengin-Lecreulx, D. (2004) J. Biol. Chem...
Tatar L, Marolda C, Polischuk A, van Leeuwen D, Valvano M. An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling. Microbiology. 2007;153:2518-29 pubmed
..Four Und-PP pyrophosphatases were recently identified in Escherichia coli. One of these, UppP (formerly BacA), accounts for 75 % of the total cellular Und-PP pyrophosphatase activity and has been suggested to participate in ..
Cudny H, Lupski J, Godson G, Deutscher M. Cloning, sequencing, and species relatedness of the Escherichia coli cca gene encoding the enzyme tRNA nucleotidyltransferase. J Biol Chem. 1986;261:6444-9 pubmed
..These studies have also allowed exact placement of the cca gene on the E. coli genetic map, and have shown that it is transcribed in a clockwise direction. ..
Cain B, Norton P, Eubanks W, Nick H, Allen C. Amplification of the bacA gene confers bacitracin resistance to Escherichia coli. J Bacteriol. 1993;175:3784-9 pubmed
..sequence analyses of bacitracin resistance plasmid pXV62 revealed that a single open reading frame, designated the bacA gene, was sufficient for antibiotic resistance. The bacA gene mapped to approximately 67 min on the E...
Touze T, Tran A, Hankins J, Mengin Lecreulx D, Trent M. Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate. Mol Microbiol. 2008;67:264-77 pubmed
Rezuchova B, Miticka H, Homerova D, Roberts M, Kormanec J. New members of the Escherichia coli sigmaE regulon identified by a two-plasmid system. FEMS Microbiol Lett. 2003;225:1-7 pubmed
..tufA, recR), phospholipid and lipopolysaccharide biosynthesis (psd, lpxP), signal transduction (sixA), proposed inner or outer membrane proteins (bacA, sbmA, smpA, yeaY), and proteins with unknown function (ybaB, yaiW, yiiS, yiiT, yfeY).
Chang H, Chou C, Hsu M, Wang A. Proposed carrier lipid-binding site of undecaprenyl pyrophosphate phosphatase from Escherichia coli. J Biol Chem. 2014;289:18719-35 pubmed publisher
Undecaprenyl pyrophosphate phosphatase (UppP), an integral membrane protein, catalyzes the dephosphorylation of undecaprenyl pyrophosphate to undecaprenyl phosphate, which is an essential carrier lipid in the bacterial cell wall synthesis...
Manat G, El Ghachi M, Auger R, Baouche K, Olatunji S, Kerff F, et al
. Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase. PLoS ONE. 2015;10:e0142870 pubmed publisher
..activity were previously identified in Escherichia coli that belonged to two distinct protein families: the BacA protein, which accounts for 75% of the C55-PP phosphatase activity detected in E...