Genomes and Genes
Gene Symbol: asnA
Description: asparagine synthetase A
Alias: ECK3738, JW3722
Species: Escherichia coli str. K-12 substr. MG1655
- Sugiyama A, Kato H, Nishioka T, Oda J. Overexpression and purification of asparagine synthetase from Escherichia coli. Biosci Biotechnol Biochem. 1992;56:376-9 pubmedOverexpression of the asnA gene from Escherichia coli K-12 coding for asparagine synthetase (EC 18.104.22.168) was achieved with a plasmid, pUNAd37, a derivative of pUC18, in E. coli...
- Kölling R, Lother H. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli. J Bacteriol. 1985;164:310-5 pubmed..It was shown that the 17-kilodalton gene, which is transcribed divergently from the adjacent asnA gene, codes for an activator of asnA transcription...
- Wackett L, Wanner B, Venditti C, Walsh C. Involvement of the phosphate regulon and the psiD locus in carbon-phosphorus lyase activity of Escherichia coli K-12. J Bacteriol. 1987;169:1753-6 pubmed..Since psiD::lacZ(Mu d1) mutants cannot metabolize methylphosphonic acid, psiD may be the structural gene(s) for C-P lyase. ..
- Humbert R, Simoni R. Genetic and biomedical studies demonstrating a second gene coding for asparagine synthetase in Escherichia coli. J Bacteriol. 1980;142:212-20 pubmed..The former asn locus is now called asnA, and the new gene is designated asnB. The asnB gene is located near gal...
- Felton J, Michaelis S, Wright A. Mutations in two unlinked genes are required to produce asparagine auxotrophy in Escherichia coli. J Bacteriol. 1980;142:221-8 pubmedEscherichia coli K-12 has two genes, asnA+ and asnB+, either one of which is able to satisfy the need of cells for asparagine...
- Buhk H, Messer W. The replication origin region of Escherichia coli: nucleotide sequence and functional units. Gene. 1983;24:265-79 pubmed..The coding regions for proteins were identified, and the possible function of those proteins is discussed. Within oriC two extended systems of dyad symmetry were found, and their possible significance is considered. ..
- Nakatsu T, Kato H, Oda J. Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase. Nat Struct Biol. 1998;5:15-9 pubmed..The functional and structural similarities of both enzymes suggest that new enzymatic activities would generally follow the recruitment of a protein catalyzing a similar chemical reaction. ..