Gene Symbol: arsC
Description: arsenate reductase
Alias: ECK3488, JW3470, arsG
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Cai J, DuBow M. Expression of the Escherichia coli chromosomal ars operon. Can J Microbiol. 1996;42:662-71 pubmed
    ..DNA sequencing revealed three open reading frames homologous to the arsR, arsB, and arsC open reading frames of plasmid-based arsenic resistance operons isolated from both E...
  2. Liu J, Rosen B. Ligand interactions of the ArsC arsenate reductase. J Biol Chem. 1997;272:21084-9 pubmed
    b>ArsC encoded by Escherichia coli plasmid R773 catalyzes the reduction of arsenate to arsenite. The enzymatic reaction requires reduced glutathione and glutaredoxin...
  3. Rosen B, Liu Z. Transport pathways for arsenic and selenium: a minireview. Environ Int. 2009;35:512-5 pubmed publisher
    ..In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification. ..
  4. Diorio C, Cai J, Marmor J, Shinder R, DuBow M. An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria. J Bacteriol. 1995;177:2050-6 pubmed
    ..chromosomal operon was cloned, sequenced, and found to consist of three cistrons which we named arsR, arsB, and arsC because of their strong homology to plasmid-borne ars operons...
  5. Carlin A, Shi W, Dey S, Rosen B. The ars operon of Escherichia coli confers arsenical and antimonial resistance. J Bacteriol. 1995;177:981-6 pubmed
    ..Expression of the ars genes was inducible by arsenite. By Southern hybridization, the operon was found in all strains of E. coli examined but not in Salmonella typhimurium, Pseudomonas aeruginosa, or Bacillus subtilis. ..
  6. Shi J, Vlamis Gardikas A, Aslund F, Holmgren A, Rosen B. Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. J Biol Chem. 1999;274:36039-42 pubmed
    In Escherichia coli ArsC catalyzes the reduction of arsenate to arsenite using GSH with glutaredoxin as electron donors. E. coli has three glutaredoxins: 1, 2, and 3, each with a classical -Cys-Pro-Tyr-Cys- active site...
  7. Mukhopadhyay R, Rosen B. Arsenate reductases in prokaryotes and eukaryotes. Environ Health Perspect. 2002;110 Suppl 5:745-8 pubmed
    ..The properties of two of these are described here. The first is the prokaryotic ArsC arsenate reductase of Escherichia coli...
  8. Busenlehner L, Pennella M, Giedroc D. The SmtB/ArsR family of metalloregulatory transcriptional repressors: Structural insights into prokaryotic metal resistance. FEMS Microbiol Rev. 2003;27:131-43 pubmed
    ..We hypothesize that distinct allosteric pathways for metal sensing have co-evolved with metal specificities of distinct alpha3N and alpha5 coordination complexes. ..
  9. Han K, Park J, Seo H, Ahn K, Lee J. Multiple stressor-induced proteome responses of Escherichia coli BL21(DE3). J Proteome Res. 2008;7:1891-903 pubmed publisher
    ..The quantitative and systematic proteome analyses that we have performed provide more detailed information on E. coli BL21(DE3), a widely used host strain for recombinant protein overexpression. ..

More Information


  1. DeMel S, Shi J, Martin P, Rosen B, Edwards B. Arginine 60 in the ArsC arsenate reductase of E. coli plasmid R773 determines the chemical nature of the bound As(III) product. Protein Sci. 2004;13:2330-40 pubmed
    ..Consequently, organisms detoxify arsenate by reduction to arsenite, which is then excreted or sequestered. The ArsC arsenate reductase from Escherichia coli plasmid R773, the best characterized arsenic-modifying enzyme, has a ..
  2. Messens J, Silver S. Arsenate reduction: thiol cascade chemistry with convergent evolution. J Mol Biol. 2006;362:1-17 pubmed
    ..The arsenate reductases (ArsC) from different sources have unrelated sequences and structural folds, and can be divided into different classes on ..