arcB

Summary

Gene Symbol: arcB
Description: aerobic respiration control sensor histidine protein kinase, cognate to two-component response regulators ArcA and RssB
Alias: ECK3200, JW5536
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Mika F, Hengge R. A two-component phosphotransfer network involving ArcB, ArcA, and RssB coordinates synthesis and proteolysis of sigmaS (RpoS) in E. coli. Genes Dev. 2005;19:2770-81 pubmed
    ..The histidine sensor kinase ArcB not only phosphorylates ArcA, but also the sigma(S) proteolytic targeting factor RssB, and thereby stimulates sigma(..
  2. Iuchi S. Phosphorylation/dephosphorylation of the receiver module at the conserved aspartate residue controls transphosphorylation activity of histidine kinase in sensor protein ArcB of Escherichia coli. J Biol Chem. 1993;268:23972-80 pubmed
    A membrane sensor protein, ArcB, recognizes anaerobic environments and signals the information to the cognate regulator, ArcA. This in vitro study presents the process and control of the signal-transduction phosphorylation...
  3. Jovanovic G, Lloyd L, Stumpf M, Mayhew A, Buck M. Induction and function of the phage shock protein extracytoplasmic stress response in Escherichia coli. J Biol Chem. 2006;281:21147-61 pubmed
    ..We show that the Psp-inducing protein IV secretin stress, in the absence of Psp proteins, decreases the pmf in an ArcB-dependent manner and that ArcB is required for amplifying and transducing the stress signal to the PspF regulon...
  4. Georgellis D, Kwon O, Lin E. Quinones as the redox signal for the arc two-component system of bacteria. Science. 2001;292:2314-6 pubmed
    ..Under anaerobic conditions, the ArcB sensor kinase autophosphorylates and then transphosphorylates ArcA, a global transcriptional regulator that ..
  5. Georgellis D, Lynch A, Lin E. In vitro phosphorylation study of the arc two-component signal transduction system of Escherichia coli. J Bacteriol. 1997;179:5429-35 pubmed
    The ArcB and ArcA proteins constitute a two-component signal transduction system that plays a broad role in transcriptional regulation...
  6. Georgellis D, Kwon O, Lin E. Amplification of signaling activity of the arc two-component system of Escherichia coli by anaerobic metabolites. An in vitro study with different protein modules. J Biol Chem. 1999;274:35950-4 pubmed
    ..This system consists of ArcB as the membrane-associated sensor kinase and ArcA as the cytoplasmic response regulator...
  7. Iuchi S, Matsuda Z, Fujiwara T, Lin E. The arcB gene of Escherichia coli encodes a sensor-regulator protein for anaerobic repression of the arc modulon. Mol Microbiol. 1990;4:715-27 pubmed
    The arcA (dye) and arcB genes of Escherichia coli are responsible for anaerobic repression of target operons and regulons of aerobic function (the arc modulon)...
  8. Kwon O, Georgellis D, Lin E. Phosphorelay as the sole physiological route of signal transmission by the arc two-component system of Escherichia coli. J Bacteriol. 2000;182:3858-62 pubmed
    The Arc two-component system, comprising a tripartite sensor kinase (ArcB) and a response regulator (ArcA), modulates the expression of numerous genes involved in respiratory functions...
  9. Gunsalus R, Park S. Aerobic-anaerobic gene regulation in Escherichia coli: control by the ArcAB and Fnr regulons. Res Microbiol. 1994;145:437-50 pubmed
    ..The cell has two distinctly different transcriptional regulators, consisting of the Fnr and the ArcA/ArcB regulatory proteins to accomplish this task...

More Information

Publications74

  1. Lee Y, Han J, Jeon Y, Hwang D. The arc two-component signal transduction system inhibits in vitro Escherichia coli chromosomal initiation. J Biol Chem. 2001;276:9917-23 pubmed
    ..conditions, Escherichia coli operates a two-component signal transduction system, termed Arc, that consists of ArcB protein, a transmembrane sensor kinase and ArcA protein, the cognate response regulator...
  2. Iuchi S, Lin E. Mutational analysis of signal transduction by ArcB, a membrane sensor protein responsible for anaerobic repression of operons involved in the central aerobic pathways in Escherichia coli. J Bacteriol. 1992;174:3972-80 pubmed
    ..of operons involved in aerobic metabolism is regulated by a two-component signal transduction system in which the arcB gene specifies the membrane sensor protein and the arcA gene specifies the cytoplasmic regulator protein...
  3. Alexeeva S, Hellingwerf K, Teixeira De Mattos M. Requirement of ArcA for redox regulation in Escherichia coli under microaerobic but not anaerobic or aerobic conditions. J Bacteriol. 2003;185:204-9 pubmed
    ..Thus, the ArcA regulator was found to exert major control on flux distribution, and it is concluded that the ArcAB system should be considered a microaerobic redox regulator. ..
  4. Iuchi S, Cameron D, Lin E. A second global regulator gene (arcB) mediating repression of enzymes in aerobic pathways of Escherichia coli. J Bacteriol. 1989;171:868-73 pubmed
    ..In this study we identified a second pleiotropic control gene, arcB, at min 69.5...
  5. Iuchi S, Lin E. arcA (dye), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic pathways. Proc Natl Acad Sci U S A. 1988;85:1888-92 pubmed
    ..1983) Microbiol. Rev. 47, 180-230]. A dye-deletion mutant was derepressed in the aerobic enzyme system. The term modulon is proposed to describe a set of regulons that are subject to a common transcriptional control. ..
  6. Jeon Y, Lee Y, Han J, Kim J, Hwang D. Multimerization of phosphorylated and non-phosphorylated ArcA is necessary for the response regulator function of the Arc two-component signal transduction system. J Biol Chem. 2001;276:40873-9 pubmed
    ..Escherichia coli operates the Arc two-component signal transduction system, consisting of a sensor kinase, ArcB, and a response regulator, ArcA...
  7. Matsushika A, Mizuno T. A dual-signaling mechanism mediated by the ArcB hybrid sensor kinase containing the histidine-containing phosphotransfer domain in Escherichia coli. J Bacteriol. 1998;180:3973-7 pubmed
    The two components ArcB and ArcA play a crucial role in the signal transduction implicated in the complex transcriptional regulatory network that allows Escherichia coli to sense various respiratory growth conditions...
  8. Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D. Identification of a quinone-sensitive redox switch in the ArcB sensor kinase. Proc Natl Acad Sci U S A. 2004;101:13318-23 pubmed
    ..Under anaerobic conditions, the ArcB sensor kinase autophosphorylates and transphosphorylates ArcA, a global transcriptional regulator that controls the ..
  9. Georgellis D, Kwon O, De Wulf P, Lin E. Signal decay through a reverse phosphorelay in the Arc two-component signal transduction system. J Biol Chem. 1998;273:32864-9 pubmed
    ..Under those conditions, the tripartite sensor kinase ArcB undergoes autophosphorylation at the expense of ATP and subsequently transphosphorylates its cognate response ..
  10. Iuchi S, Lin E. Purification and phosphorylation of the Arc regulatory components of Escherichia coli. J Bacteriol. 1992;174:5617-23 pubmed
    In Escherichia coli, a two-component signal transduction system, consisting of the transmembrane sensor protein ArcB and its cognate cytoplasmic regulatory protein ArcA, controls the expression of genes encoding enzymes involved in ..
  11. Liu X, De Wulf P. Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling. J Biol Chem. 2004;279:12588-97 pubmed
    The ArcB/ArcA two-component signal transduction system of Escherichia coli regulates gene expression in response to the redox conditions of growth...
  12. Peercy B, Cox S, Shalel Levanon S, San K, Bennett G. A kinetic model of oxygen regulation of cytochrome production in Escherichia coli. J Theor Biol. 2006;242:547-63 pubmed
    ..Toward this end we build and analyse a mathematical model that captures the role played by oxygen in the regulation of cytochrome production in E. coli. ..
  13. Kwon O, Georgellis D, Lin E. Rotational on-off switching of a hybrid membrane sensor kinase Tar-ArcB in Escherichia coli. J Biol Chem. 2003;278:13192-5 pubmed
    ..The ArcB sensor kinase of E. coli is a transmembrane protein without a significant periplasmic domain...
  14. Kato Y, Sugiura M, Mizuno T, Aiba H. Effect of the arcA mutation on the expression of flagella genes in Escherichia coli. Biosci Biotechnol Biochem. 2007;71:77-83 pubmed
    ..The phosphorylation site of ArcA is necessary for motility, while a cognate histidine kinase, ArcB, appears not to be involved in motility...
  15. Wu M, Schleif R. Mapping arm-DNA-binding domain interactions in AraC. J Mol Biol. 2001;307:1001-9 pubmed
    ..They form a contiguous trail on the DNA-distal face of the DNA-binding domain, and likely define the region where the N-terminal arm that extends from the N-terminal dimerization domain contacts the C-terminal DNA-binding domain. ..
  16. Ishige K, Nagasawa S, Tokishita S, Mizuno T. A novel device of bacterial signal transducers. EMBO J. 1994;13:5195-202 pubmed
    ..Among such suppressors, arcB and barA are of particular interest because these gene products are unique in the sense that they contain both an ..
  17. Bidart G, Ruiz J, de Almeida A, Méndez B, Nikel P. Manipulation of the anoxic metabolism in Escherichia coli by ArcB deletion variants in the ArcBA two-component system. Appl Environ Microbiol. 2012;78:8784-94 pubmed publisher
    ..The ArcBA two-component system consists of ArcB, a membrane-associated sensor kinase, and ArcA, the cognate response regulator...
  18. Matsushika A, Mizuno T. Mutational analysis of the histidine-containing phosphotransfer (HPt) signaling domain of the ArcB sensor in Escherichia coli. Biosci Biotechnol Biochem. 1998;62:2236-8 pubmed
    The Escherichia coli ArcB sensor is involved in anaerobic phosphotransfer signal transduction...
  19. Alexeeva S, de Kort B, Sawers G, Hellingwerf K, de Mattos M. Effects of limited aeration and of the ArcAB system on intermediary pyruvate catabolism in Escherichia coli. J Bacteriol. 2000;182:4934-40 pubmed
  20. Wall D, Delaney J, Fayet O, Lipinska B, Yamamoto T, Georgopoulos C. arc-dependent thermal regulation and extragenic suppression of the Escherichia coli cytochrome d operon. J Bacteriol. 1992;174:6554-62 pubmed
    ..shock induction of the cyd operon was not affected in an rpoH delta background but was totally absent in an arcA or arcB mutant background. Extragenic suppressors of the Cyd Ts- phenotype are found at approximately 10(-3)...
  21. Hamada K, Kato M, Shimizu T, Ihara K, Mizuno T, Hakoshima T. Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay. Genes Cells. 2005;10:1-11 pubmed
    ..against the histidine-containing phosphotransfer (HPt) domain located in the C-terminus of the histidine kinase ArcB engaged in anaerobic responses...
  22. Krishnamoorthy G, Tikhonova E, Dhamdhere G, Zgurskaya H. On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein. Mol Microbiol. 2013;87:982-97 pubmed publisher
    ..coli. Our findings explain why TolC is not a good target for inhibition of multidrug efflux. ..
  23. Iuchi S, Lin E. Adaptation of Escherichia coli to redox environments by gene expression. Mol Microbiol. 1993;9:9-15 pubmed
    ..of transcription, the goal is achieved by the interaction of three global regulatory systems, Fnr, NarL/NarX and ArcB/ArcA...
  24. Perrenoud A, Sauer U. Impact of global transcriptional regulation by ArcA, ArcB, Cra, Crp, Cya, Fnr, and Mlc on glucose catabolism in Escherichia coli. J Bacteriol. 2005;187:3171-9 pubmed
    ..of intracellular fluxes, we systematically elucidated the relevance of global transcriptional regulation by ArcA, ArcB, Cra, Crp, Cya, Fnr, and Mlc for aerobic glucose catabolism in batch cultures of Escherichia coli...
  25. Kato M, Mizuno T, Shimizu T, Hakoshima T. Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB. Cell. 1997;88:717-23 pubmed
    ..The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined at 2.06 A resolution...
  26. Nanchen A, Schicker A, Revelles O, Sauer U. Cyclic AMP-dependent catabolite repression is the dominant control mechanism of metabolic fluxes under glucose limitation in Escherichia coli. J Bacteriol. 2008;190:2323-30 pubmed publisher
    ..analysis of Escherichia coli mutants, we elucidated the relevance of global transcriptional regulation by ArcA, ArcB, Cra, CreB, CreC, Crp, Cya, Fnr, Hns, Mlc, OmpR, and UspA on aerobic glucose catabolism in glucose-limited ..
  27. Ogasawara H, Teramoto J, Yamamoto S, Hirao K, Yamamoto K, Ishihama A, et al. Negative regulation of DNA repair gene (uvrA) expression by ArcA/ArcB two-component system in Escherichia coli. FEMS Microbiol Lett. 2005;251:243-9 pubmed
    The ArcA/ArcB two-component signal transduction system of Escherichia coli regulates gene expression in response to the redox conditions of growth. In this study, uvrA gene expression was repressed when ArcA was induced in E. coli...
  28. Deniaud A, Goulielmakis A, Coves J, Pebay Peyroula E. Differences between CusA and AcrB crystallisation highlighted by protein flexibility. PLoS ONE. 2009;4:e6214 pubmed publisher
    ..Addition of various compounds, in particular heavy metal cations, stabilises CusA. This approach could constitute a first step towards CusA crystallisation. ..
  29. Matsushika A, Mizuno T. The structure and function of the histidine-containing phosphotransfer (HPt) signaling domain of the Escherichia coli ArcB sensor. J Biochem. 1998;124:440-5 pubmed
    The Escherichia coli ArcB sensor is involved in anaerobic signal transduction...
  30. Bekker M, Alexeeva S, Laan W, Sawers G, Teixeira de Mattos J, Hellingwerf K. The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool. J Bacteriol. 2010;192:746-54 pubmed publisher
    ..Based on in vitro data, it has been postulated that the redox state of the ubiquinone pool is the determinant for ArcB kinase activity...
  31. Matsushika A, Mizuno T. Characterization of three putative sub-domains in the signal-input domain of the ArcB hybrid sensor in Escherichia coli(1). J Biochem. 2000;127:855-60 pubmed
    The ArcB sensor plays a crucial role in the histidine to aspartate (His-to-Asp) phosphorelay signal transduction, which is involved in the transcriptional regulatory network that allows Escherichia coli cells to sense various respiratory ..
  32. Huvet M, Toni T, Tan H, Jovanovic G, Engl C, Buck M, et al. Model-based evolutionary analysis: the natural history of phage-shock stress response. Biochem Soc Trans. 2009;37:762-7 pubmed publisher
    ..We use the specific example of the phage-shock stress response, which has been well characterized in Escherichia coli, to elucidate patterns of gene sharing and sequence conservation across bacterial species. ..
  33. Alvarez A, Rodriguez C, Georgellis D. Ubiquinone and menaquinone electron carriers represent the yin and yang in the redox regulation of the ArcB sensor kinase. J Bacteriol. 2013;195:3054-61 pubmed publisher
    The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to respiratory growth conditions...
  34. Iuchi S, Chepuri V, Fu H, Gennis R, Lin E. Requirement for terminal cytochromes in generation of the aerobic signal for the arc regulatory system in Escherichia coli: study utilizing deletions and lac fusions of cyo and cyd. J Bacteriol. 1990;172:6020-5 pubmed
    ..A mutation in either the sensor gene arcB or the pleiotropic regulator gene arcA almost abolishes the anaerobic repression...
  35. Peña Sandoval G, Kwon O, Georgellis D. Requirement of the receiver and phosphotransfer domains of ArcB for efficient dephosphorylation of phosphorylated ArcA in vivo. J Bacteriol. 2005;187:3267-72 pubmed
    The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory conditions of growth...
  36. Iuchi S, Furlong D, Lin E. Differentiation of arcA, arcB, and cpxA mutant phenotypes of Escherichia coli by sex pilus formation and enzyme regulation. J Bacteriol. 1989;171:2889-93 pubmed
    In Escherichia coli, mutations in arcA (dye) or arcB anaerobically derepress the synthesis of a multitude of enzymes of aerobic function, and mutations in arcA or cpxA impair F-pilus formation...
  37. Loui C, Chang A, Lu S. Role of the ArcAB two-component system in the resistance of Escherichia coli to reactive oxygen stress. BMC Microbiol. 2009;9:183 pubmed publisher
    ..To investigate the mechanism of ROS resistance mediated by ArcAB, we generated deletion mutants of ArcA and ArcB in E. coli...
  38. Rodriguez C, Kwon O, Georgellis D. Effect of D-lactate on the physiological activity of the ArcB sensor kinase in Escherichia coli. J Bacteriol. 2004;186:2085-90 pubmed
    The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory growth conditions...
  39. Brøndsted L, Atlung T. Anaerobic regulation of the hydrogenase 1 (hya) operon of Escherichia coli. J Bacteriol. 1994;176:5423-8 pubmed
  40. Iuchi S, Lin E. Adaptation of Escherichia coli to respiratory conditions: regulation of gene expression. Cell. 1991;66:5-7 pubmed
  41. Alvarez A, Malpica R, Contreras M, Escamilla E, Georgellis D. Cytochrome d but not cytochrome o rescues the toluidine blue growth sensitivity of arc mutants of Escherichia coli. J Bacteriol. 2010;192:391-9 pubmed publisher
    The Arc (anoxic redox control) two-component signal transduction system, consisting of the ArcB sensor kinase and the ArcA response regulator, allows adaptive responses of Escherichia coli to changes of O(2) availability...
  42. Jovanovic G, Engl C, Buck M. Physical, functional and conditional interactions between ArcAB and phage shock proteins upon secretin-induced stress in Escherichia coli. Mol Microbiol. 2009;74:16-28 pubmed publisher
    ..ArcAB, predominantly through the action of ArcA regulated genes, but also via a direct ArcB-Psp interaction, is required to propagate the protein IV (pIV)-dependent psp-inducing signal(s) during ..
  43. Matsubara M, Mizuno T. The SixA phospho-histidine phosphatase modulates the ArcB phosphorelay signal transduction in Escherichia coli. FEBS Lett. 2000;470:118-24 pubmed
    ..multi-copy state, the cross-phosphorelay between the histidine-containing phosphotransmitter (HPt) domain of the ArcB anaerobic sensor and its non-cognate OmpR response regulator...
  44. Peña Sandoval G, Georgellis D. The ArcB sensor kinase of Escherichia coli autophosphorylates by an intramolecular reaction. J Bacteriol. 2010;192:1735-9 pubmed publisher
    The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory conditions of growth...
  45. Struve C, Forestier C, Krogfelt K. Application of a novel multi-screening signature-tagged mutagenesis assay for identification of Klebsiella pneumoniae genes essential in colonization and infection. Microbiology. 2003;149:167-76 pubmed
    ..Transposon insertion sites in attenuated mutants were, among others, in genes encoding well-known K. pneumoniae virulence factors such as lipopolysaccharide and capsule, as well as in genes of unknown function...
  46. Compan I, Touati D. Anaerobic activation of arcA transcription in Escherichia coli: roles of Fnr and ArcA. Mol Microbiol. 1994;11:955-64 pubmed
    ..Fnr activation of arcA transcription may play an important role in the co-ordination of expression of genes associated with aerobic and anaerobic metabolism during environmental changes. ..
  47. Iuchi S, Aristarkhov A, Dong J, Taylor J, Lin E. Effects of nitrate respiration on expression of the Arc-controlled operons encoding succinate dehydrogenase and flavin-linked L-lactate dehydrogenase. J Bacteriol. 1994;176:1695-701 pubmed
    ..The repression is initiated by autophosphorylation of the sensor protein ArcB, followed by phosphoryl group transfer to the regulator ArcA...
  48. Matsubara M, Kitaoka S, Takeda S, Mizuno T. Tuning of the porin expression under anaerobic growth conditions by his-to-Asp cross-phosphorelay through both the EnvZ-osmosensor and ArcB-anaerosensor in Escherichia coli. Genes Cells. 2000;5:555-69 pubmed
    ..We have addressed this issue, with special reference to the osmo-responsive EnvZ and anaero-responsive ArcB phosphorelay signalling pathways in E. coli...
  49. Colloms S, Alen C, Sherratt D. The ArcA/ArcB two-component regulatory system of Escherichia coli is essential for Xer site-specific recombination at psi. Mol Microbiol. 1998;28:521-30 pubmed
    ..Here, we demonstrate that the ArcA/ArcB two-component regulatory system of Escherichia coli, which mediates adaptation to anaerobic growth conditions, is ..
  50. Yaku H, Kato M, Hakoshima T, Tsuzuki M, Mizuno T. Interaction between the CheY response regulator and the histidine-containing phosphotransfer (HPt) domain of the ArcB sensory kinase in Escherichia coli. FEBS Lett. 1997;408:337-40 pubmed
    ..The ArcB anaerobic sensor of E. coli contains such a HPt domain, although its function is not fully understood...
  51. Ogino T, Matsubara M, Kato N, Nakamura Y, Mizuno T. An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay. Mol Microbiol. 1998;27:573-85 pubmed
    The Escherichia coli sensory kinase, ArcB, possesses a histidine-containing phosphotransfer (HPt) domain, which is implicated in the His-Asp multistep phosphorelay...
  52. Kwon O, Georgellis D, Lynch A, Boyd D, Lin E. The ArcB sensor kinase of Escherichia coli: genetic exploration of the transmembrane region. J Bacteriol. 2000;182:2960-6 pubmed
    ..redox state or proton motive force (Delta(H(+))) has been proposed to be the signal for the membrane-associated ArcB sensor kinase. This study provided evidence for a short ArcB periplasmic bridge that contains a His47...
  53. Kato M, Mizuno T, Hakoshima T. Crystallization of a complex between a novel C-terminal transmitter, HPt domain, of the anaerobic sensor kinase ArcB and the chemotaxis response regulator CheY. Acta Crystallogr D Biol Crystallogr. 1998;54:140-2 pubmed
    The histidine-containing phosphotransfer (HPt) domain at the C-terminus of the anaerobic sensor kinase ArcB has been cocrystallized with the chemotaxis response regulator CheY by a hanging-drop vapor-diffusion method...
  54. Sacco S, Adolfsen K, Brynildsen M. An integrated network analysis identifies how ArcAB enables metabolic oscillations in the nitric oxide detoxification network of Escherichia coli. Biotechnol J. 2017;12: pubmed publisher
    ..The authors observed that wild-type, ΔarcA, and ΔarcB had comparable initial NO• clearance times; however, the mutant cultures failed to exhibit [NO•] and [O<..
  55. Aiso T, Ohki R. Instability of sensory histidine kinase mRNAs in Escherichia coli. Genes Cells. 2003;8:179-87 pubmed
    ..In this study we analysed the stability of sensory kinase mRNAs, e.g. arcB, barA, rcsC, narQ, narX and evgS mRNA...
  56. Maslennikov I, Klammt C, Hwang E, Kefala G, Okamura M, Esquivies L, et al. Membrane domain structures of three classes of histidine kinase receptors by cell-free expression and rapid NMR analysis. Proc Natl Acad Sci U S A. 2010;107:10902-7 pubmed publisher
    ..The ArcB and QseC TM domains are both two-helical motifs, whereas the KdpD TM domain comprises a four-helical bundle with ..
  57. Lin E, Iuchi S. Regulation of gene expression in fermentative and respiratory systems in Escherichia coli and related bacteria. Annu Rev Genet. 1991;25:361-87 pubmed
  58. Cotter P, Melville S, Albrecht J, Gunsalus R. Aerobic regulation of cytochrome d oxidase (cydAB) operon expression in Escherichia coli: roles of Fnr and ArcA in repression and activation. Mol Microbiol. 1997;25:605-15 pubmed
    ..Expression of the cydAB operon is microaerobically controlled by the ArcA/ArcB two-component regulatory system and by Fnr...
  59. Tsuzuki M, Ishige K, Mizuno T. Phosphotransfer circuitry of the putative multi-signal transducer, ArcB, of Escherichia coli: in vitro studies with mutants. Mol Microbiol. 1995;18:953-62 pubmed
    ..This class of bacterial sensory kinases, typified by ArcB and BarA, possesses two phospho-donor (His) sites, together with a phospho-accepting (Asp) site...
  60. Levanon S, San K, Bennett G. Effect of oxygen on the Escherichia coli ArcA and FNR regulation systems and metabolic responses. Biotechnol Bioeng. 2005;89:556-64 pubmed
    ..The activity of FNR-regulated pathways in the arcA mutant strain is correlated with the high redox potential obtained under microaerobic growth. ..
  61. Sawers G, Suppmann B. Anaerobic induction of pyruvate formate-lyase gene expression is mediated by the ArcA and FNR proteins. J Bacteriol. 1992;174:3474-8 pubmed
    ..A mutant strain unable to synthesize the membrane-associated histidine kinase (ArcB) that has been proposed to activate ArcA showed the same phenotype as an arcA mutant strain, indicating that a ..
  62. Liu X, Peña Sandoval G, Wanner B, Jung W, Georgellis D, Kwon O. Evidence against the physiological role of acetyl phosphate in the phosphorylation of the ArcA response regulator in Escherichia coli. J Microbiol. 2009;47:657-62 pubmed publisher
    The Arc two-component signal transduction system of Escherichia coli comprises the ArcB sensor kinase and the ArcA response regulator...
  63. Ikegami T, Okada T, Ohki I, Hirayama J, Mizuno T, Shirakawa M. Solution structure and dynamic character of the histidine-containing phosphotransfer domain of anaerobic sensor kinase ArcB from Escherichia coli. Biochemistry. 2001;40:375-86 pubmed
    An Escherichia coli sensor kinase, ArcB, transfers a phosphoryl group to a partner response regulator in response to anaerobic conditions...
  64. Wang Z, Fan G, Hryc C, Blaza J, Serysheva I, Schmid M, et al. An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. elife. 2017;6: pubmed publisher
    ..Within the transport-activated state, the channel remains open even though the pump cycles through three distinct conformations. Collectively, our data provide a dynamic mechanism for the assembly and operation of the AcrAB-TolC pump. ..
  65. Kato M, Mizuno T, Shimizu T, Hakoshima T. Refined structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli at 1.57 A resolution. Acta Crystallogr D Biol Crystallogr. 1999;55:1842-9 pubmed
    The crystal structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli has been refined to 1.57 A resolution, using the coordinates of the earlier 2...