Gene Symbol: adi
Description: arginine decarboxylase
Alias: ECK4110, JW5731, adi
Species: Escherichia coli str. K-12 substr. MG1655

Top Publications

  1. Richard H, Foster J. Acid resistance in Escherichia coli. Adv Appl Microbiol. 2003;52:167-86 pubmed
    ..5. They also protect against acid stress involved in food processing and facilitate the low infectious dose characteristic of E. coli, significantly contributing to the pathogenesis of this organism. ..
  2. Hassani M, Pincus D, Bennett G, Hirshfield I. Temperature-dependent induction of an acid-inducible stimulon of Escherichia coli in broth. Appl Environ Microbiol. 1992;58:2704-7 pubmed
    ..5 or less is temperature dependent, being distinctly lower at 24 than at 37 degrees C. This induction does not appear to be under HtpR control. ..
  3. Bi H, Sun L, Fukamachi T, Saito H, Kobayashi H. HU participates in expression of a specific set of genes required for growth and survival at acidic pH in Escherichia coli. Curr Microbiol. 2009;58:443-8 pubmed publisher
    ..These results suggest that HU regulates expression of the specific set of genes required for growth and survival in acidic environments. ..
  4. Blethen S, Boeker E, Snell E. Argenine decarboxylase from Escherichia coli. I. Purification and specificity for substrates and coenzyme. J Biol Chem. 1968;243:1671-7 pubmed
  5. Boeker E, Snell E. Arginine decarboxylase from Escherichia coli. II. Dissociation and reassociation of subunits. J Biol Chem. 1968;243:1678-84 pubmed
  6. Shi X, Bennett G. Plasmids bearing hfq and the hns-like gene stpA complement hns mutants in modulating arginine decarboxylase gene expression in Escherichia coli. J Bacteriol. 1994;176:6769-75 pubmed
  7. Shi X, Bennett G. Effects of rpoA and cysB mutations on acid induction of biodegradative arginine decarboxylase in Escherichia coli. J Bacteriol. 1994;176:7017-23 pubmed
    ..We obtained a number of these mutants and examined the effects of these mutations on the acid induction of adi and cad gene expression. Several mutations caused a small reduction in adi promoter activity at inducing pH...
  8. Shi X, Waasdorp B, Bennett G. Modulation of acid-induced amino acid decarboxylase gene expression by hns in Escherichia coli. J Bacteriol. 1993;175:1182-6 pubmed
    Biodegradative arginine decarboxylase and lysine decarboxylase, encoded by adi and cadA, respectively, are induced to maximal levels when Escherichia coli is grown anaerobically in rich medium at acidic pH...
  9. Stim K, Bennett G. Nucleotide sequence of the adi gene, which encodes the biodegradative acid-induced arginine decarboxylase of Escherichia coli. J Bacteriol. 1993;175:1221-34 pubmed
    Arginine decarboxylase (encoded by adi) is induced under conditions of acidic pH, anaerobiosis, and rich medium...

More Information


  1. Volke A, Wegener G, Vasar E, Volke V. High-performance liquid chromatography method with radiochemical detection for measurement of nitric oxide synthase, arginase, and arginine decarboxylase activities. Methods Find Exp Clin Pharmacol. 2006;28:3-6 pubmed
    ..Using the current method, we have shown the formation of L-citrulline and L-ornithine in vitro using brain tissue homogenate of rats and that of agmatine by Escherichia coli ADC. ..
  2. Rowbury R. Regulatory components, including integration host factor, CysB and H-NS, that influence pH responses in Escherichia coli. Lett Appl Microbiol. 1997;24:319-28 pubmed
  3. Castanie Cornet M, Penfound T, Smith D, Elliott J, Foster J. Control of acid resistance in Escherichia coli. J Bacteriol. 1999;181:3525-35 pubmed
  4. Webster C, Kempsell K, Booth I, Busby S. Organisation of the regulatory region of the Escherichia coli melibiose operon. Gene. 1987;59:253-63 pubmed
    ..The nucleotide sequence covering the divergent promoters and the melR gene is reported. ..
  5. Stewart N, Feng J, Liu X, Chaudhuri D, Foster J, Drolet M, et al. Loss of topoisomerase I function affects the RpoS-dependent and GAD systems of acid resistance in Escherichia coli. Microbiology. 2005;151:2783-91 pubmed
    ..The effect of the topA mutation could be suppressed by an hns mutation, so topoisomerase I might be required to counteract the effect of H-NS protein on gene expression, in addition to its influence on RpoS-dependent transcription. ..
  6. Melnykovych G, Snell E. Nutritional requirements for the formation of arginine decarboxylase in Escherichia coli. J Bacteriol. 1958;76:518-23 pubmed
  7. SHER I, Mallette M. Purification and study of L-arginine decarboxylase from Escherichia coli B. Arch Biochem Biophys. 1954;53:370-80 pubmed
  8. Stim Herndon K, Flores T, Bennett G. Molecular characterization of adiY, a regulatory gene which affects expression of the biodegradative acid-induced arginine decarboxylase gene (adiA) of Escherichia coli. Microbiology. 1996;142 ( Pt 5):1311-20 pubmed
    ..designated adiY, was found downstream of the biodegradative arginine decarboxylase (adiA) gene (previously known as adi) of Escherichia coli...
  9. Richard H, Foster J. Escherichia coli glutamate- and arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potential. J Bacteriol. 2004;186:6032-41 pubmed
    ..Thus, reversing DeltaPsi may be a more important acid resistance strategy than maintaining a specific pHi value. ..
  10. Gong S, Richard H, Foster J. YjdE (AdiC) is the arginine:agmatine antiporter essential for arginine-dependent acid resistance in Escherichia coli. J Bacteriol. 2003;185:4402-9 pubmed
    ..The adi gene region was shown to be organized into two transcriptional units, adiAY and adiC, which are coordinately ..
  11. Sabo D, Fischer E. Chemical properties of Escherichia coli lysine decarboxylase including a segment of its pyridoxal 5'-phosphate binding site. Biochemistry. 1974;13:670-6 pubmed
  12. Andréll J, Hicks M, Palmer T, Carpenter E, Iwata S, Maher M. Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity. Biochemistry. 2009;48:3915-27 pubmed publisher
    ..Conversely, acidic conditions favor the assembly of active decamers. Therefore, the structure of arginine decarboxylase presents a mechanism by which its activity is modulated by external pH. ..