Gene Symbol: gag
Description: gag protein
Species: Equine infectious anemia virus
Strack B, Calistri A, Craig S, Popova E, Gottlinger H. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003;114:689-99 pubmed
..The primary late assembly (L) domain in the p6 region of HIV-1 Gag mediates the detachment of the virion by recruiting host Tsg101, a component of the class E vacuolar protein ..
Martin Serrano J, Yarovoy A, Perez Caballero D, Bieniasz P, Yaravoy A. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A. 2003;100:12414-9 pubmed
Jin J, Sturgeon T, Chen C, Watkins S, Weisz O, Montelaro R. Distinct intracellular trafficking of equine infectious anemia virus and human immunodeficiency virus type 1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays. J Virol. 2007;81:11226-35 pubmed publisher
Retroviral Gag polyproteins are necessary and sufficient for virus budding...
Nagarajan M, Simard C. Gag genetic heterogeneity of equine infectious anemia virus (EIAV) in naturally infected horses in Canada. Virus Res. 2007;129:228-35 pubmed
b>Gag genetic heterogeneity of equine infectious anemia virus (EIAV) variants in naturally infected horses in Canada was studied since very limited information is available on the variability of EIAV Gag sequences in public database...
Sharma A, Bruns K, Röder R, Henklein P, Votteler J, Wray V, et al
. Solution structure of the equine infectious anemia virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein. BMC Struct Biol. 2009;9:74 pubmed publisher
The equine infection anemia virus (EIAV) p9 Gag protein contains the late (L-) domain required for efficient virus release of nascent virions from the cell membrane of infected cell...
Wang J, Wen S, Zhao R, Qi J, Liu Z, Li W, et al
. Covalent conjugation of the equine infectious anemia virus Gag with SUMO. Biochem Biophys Res Commun. 2017;486:712-719 pubmed publisher
..Some viruses have evolved to exploit the host SUMOylation machinery to modify their own protein. Retroviral Gag protein plays critical roles in the viral life cycle...
Zhang Z, Ma J, Zhang X, Su C, Yao Q, Wang X. Equine Infectious Anemia Virus Gag Assembly and Export Are Directed by Matrix Protein through trans-Golgi Networks and Cellular Vesicles. J Virol. 2016;90:1824-38 pubmed publisher
b>Gag intracellular assembly and export are very important processes for lentiviruses replication...