Genomes and Genes
Gene Symbol: E7
Description: transforming protein
- Identification of the nuclear localization and export signals of high risk HPV16 E7 oncoproteinAlixandra A Knapp
Biology Department, Boston College, Higgins Hall, Room 578, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
Virology 383:60-8. 2009The E7 oncoprotein of high risk human papillomavirus type 16 (HPV16) binds and inactivates the retinoblastoma (RB) family of proteins...
- Expression of membrane type 1 matrix metalloproteinase in papillomavirus-positive cells: role of the human papillomavirus (HPV) 16 and HPV8 E7 gene productsSigrun Smola-Hess
Institute of Virology, University of Cologne, Fürst Pückler Strasse 56, 50935 Cologne, Germany
J Gen Virol 86:1291-6. 2005..Expression of the E7 protein from the mucosal and cutaneous high-risk types HPV16 and HPV8, but not from the cutaneous low-risk type HPV1,..
- Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulinChristine L Nguyen
Channing Laboratories, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Virol 81:13533-43. 2007Expression of a high-risk human papillomavirus (HPV) E7 oncoprotein is sufficient to induce aberrant centrosome duplication in primary human cells...
- High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsiesMarc Fiedler
Tyrolean Cancer Research Institute at the University of Innsbruck, 6020 Innsbruck, Austria
FASEB J 18:1120-2. 2004..The E7 gene is required for immortalization and maintenance of the transformed phenotype in vitro; however, little is known ..
- The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoproteinMaria M Garcia-Alai
Instituto Leloir and IIB BA CONICET, Patricias Argentinas 435, 1405 Buenos Aires, Argentina
Biochemistry 46:10405-12. 2007The HPV16 E7 oncoprotein is an extended dimer, with a stable and cooperative fold, but that displays properties of "natively unfolded" proteins...
- Down-regulation of HLA class I antigen in human papillomavirus type 16 E7 expressing HaCaT cells: correlate with TAP-1 expressionWei Li
Department of Clinical Laboratory, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China
Int J Gynecol Cancer 20:227-32. 2010High-risk human papillomaviruses (HPVs) are the major causative agents of cervical cancer, and the E6 and E7 genes encode the major HPV oncoproteins...
- The human papillomavirus-16 (HPV-16) oncoprotein E7 conjugates with and mediates the role of the transforming growth factor-beta inducible early gene 1 (TIEG1) in apoptosisHung Shu Chang
Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Taiwan, ROC
Int J Biochem Cell Biol 42:1831-9. 2010The human papillomavirus (HPV) oncoprotein E7 is a major transforming protein...
- Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytesAnna Severino
Department for the Development of Therapeutic Programs, Regina Elena Cancer Institute, Rome, Italy
J Cell Physiol 212:118-25. 2007The viral factor E7 plays a key role in the well-established association between "high-risk" Human Papillomavirus (HPV) infection and the development of epithelial malignant tumors, as uterine cervix and ano-genital cancer...
- A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoproteinB Schilling
Department of Pathology and Harvard Center for Cancer Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Virology 247:74-85. 1998..Drosophila tumor suppressor protein Tid56, by virtue of its ability to form complexes with the human papillomavirus E7 oncoprotein...
- Expression of the human papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivationXiaobo Zhou
Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, USA
Virology 385:192-7. 2009Expression of oncogenes, such as the human papillomavirus type 16 (HPV16) E7 oncoprotein, promotes aberrant cell proliferation...
- Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspinNicole Spardy
Biochemistry and Molecular Genetics Graduate Program, University of Pittsburgh School of Medicine, PA, USA
Cancer Res 69:7022-9. 2009The human papillomavirus (HPV) 16 E7 oncoprotein has been reported previously to stimulate DNA damage and to activate host cell DNA damage checkpoints...
- Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexesChristine L Nguyen
Infectious Diseases Division, Channing Laboratories 861, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Virology 380:21-5. 2008The human papillomavirus (HPV) E7 oncoprotein has been shown to associate with cyclin/CDK2 complexes...
- Repression of MHC class I transcription by HPV16E7 through interaction with a putative RXRbeta motif and NF-kappaB cytoplasmic sequestrationHui Li
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, PR China
Biochem Biophys Res Commun 388:383-8. 2009..Taken together, our results suggest that HPV16E7 may employ two independent mechanisms to ensure that either the constitutive or inducible transcription of MHC class I genes is down-regulated...
- Genetic diversity of human papillomavirus type 16 E6, E7, and L1 genes in Italian women with different grades of cervical lesionsValeria Cento
Laboratory of Molecular Virology, University Hospital Tor Vergata, Rome, Italy
J Med Virol 81:1627-34. 2009..In this study, the presence of HPV 16 polymorphisms in the E6, E7, and L1 genes was investigated in relation to the presence of high-grade lesions...
- Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cellsAmy Baldwin
The Channing Laboratory, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115
Proc Natl Acad Sci U S A 105:16478-83. 2008..To identify kinases targeted by the HPV16 E7 oncoprotein, shRNA kinase screens were performed in RKO colorectal carcinoma cell lines that differ only in their ..
- Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitosesChristine L Nguyen
Infectious Diseases Division, Channing Laboratories, Brigham and Women s Hospital and Committee on Virology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 68:8715-22. 2008..The high-risk human papillomavirus type 16 (HPV16) E7 oncoprotein induces centrosome overduplication and has been shown to cause multipolar mitotic spindle formation, a ..
- Interaction between interferon regulatory factor-1 and human papillomavirus E7 oncogene in cervical cancer: an ontology studyViroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok, Thailand
Taiwan J Obstet Gynecol 48:138-41. 2009..The E7 protein is found predominantly in the nucleus and, to a lesser extent, in the cytoplasm in cervical cancer cell ..
- HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transitionKarin Hellner
Infectious Diseases Division, The Channing Laboratories, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Virology 391:57-63. 2009..Expression of HPV16 E7 in normal human epithelial cells caused increased levels of vimentin and fibronectin, whereas the epithelial ..
- The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblastsLing Xi
Cancer Biology Research Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, PR China
Oncol Rep 21:25-31. 2009To investigate the pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts...
- Impact of connexin32 deletion on E7 or RET/PTC3 oncogene-driven growth and neoplastic transformation of the thyroid glandGaëlle Prost
Institut National de Santé et de Recherche Médicale, UMR 664, Lyon F 69372, France
Endocr Relat Cancer 16:873-84. 2009..knockout (Cx32-KO) mice were crossed with transgenic mice expressing, selectively in the thyroid gland, either the E7 or RET/PTC3 (RP3) oncogene...
- Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cellsNurshamimi Nor Rashid
Section of Virology, Department of Medicine, Imperial College London, London, UK
J Gen Virol 92:2620-7. 2011..associated with so-called high-risk HPV types, in particular HPV16, and constitutive expression of the HPV16 E6 and E7 oncoproteins is critical for malignant transformation in infected keratinocytes...
- Does the expression of HPV16/18 E6/E7 in head and neck squamous cell carcinomas relate to their clinicopathological characteristics?Yoshiko Yamakawa-Kakuta
Department of Oral and Maxillofacial Surgery, Dokkyo Medical University School of Medicine, Mibu, Shimotsuga, Tochigi 321 0293, Japan
Int J Oncol 35:983-8. 2009..We examined the expression of HPV16/18 E6/E7 in 71 cases of HNSCCs and investigated abnormalities of the p53 gene in 62 of these 71 cases...
- Human papillomavirus-16 E7 interacts with glutathione S-transferase P1 and enhances its role in cell survivalAnna M Mileo
Department of Development of Therapeutic Programs, CRS, Regina Elena Cancer Institute, Rome, Italy
PLoS ONE 4:e7254. 2009..HPV E6 and E7 viral genes are usually expressed in these tumors, suggesting key roles for their gene products, the E6 and E7 ..
- Systematic analysis of the amino acid residues of human papillomavirus type 16 E7 conserved region 3 involved in dimerization and transformationBiljana Todorovic
Department of Oncology, Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada
J Virol 85:10048-57. 2011The human papillomavirus (HPV) E7 oncoprotein exists as a dimer and acts by binding to many cellular factors, preventing or retargeting their function and thereby making the infected cell conducive for viral replication...
- Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenanceShiyuan Hong
Department of Microbiology Immunology, 303 E Chicago Ave, Morton 6 681, Chicago, IL 60611, USA
J Virol 85:9486-94. 2011..Both E6 and E7 oncoproteins independently suppress the expression of STAT-1, and mutational analyses indicate that the E6 targeting ..
- Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, ChinaZhengrong Sun
Virus Laboratory, the Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China
Int J Gynecol Cancer 21:551-8. 2011..Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV-16 are associated with risk of viral persistence and progression.
- RNA interference of human papillomavirus type 16 E7 increases HLA class I antigen expression in HaCaT-E7 cellsXiao mei Deng
Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, China
Int J Gynecol Cancer 21:28-34. 2011High-risk human papillomaviruses (HPVs) are the major causative agents of cervical cancer. The E7 protein of high-risk HPV disturbs cell cycle control and down-regulates components of the antigen presentation pathway, suggesting an ideal ..
- Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cellsLuisa Accardi
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
BMC Cancer 11:17. 2011..of the HPV genome is a frequent, though not invariable occurrence, but the constitutive expression of the E6 and E7 viral genes is always observed, suggesting key roles for the E6 and E7 oncoproteins in the process of malignant ..
- Expression of human papillomavirus type 16 E7 is sufficient to significantly increase expression of angiogenic factors but is not sufficient to induce endothelial cell migrationJoanna Walker
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Virology 410:283-90. 2011Tumor suppressors negatively regulate angiogenesis, an essential step in tumor progression. Together, HPV 16 E6 and E7 proteins, which target p53 and pRb family members, respectively, for degradation, increase the expression of two ..
- Distribution of human papillomavirus 16 E6/E7 variants in cervical cancer and intraepithelial neoplasia in Chinese womenTian Ding
Women s Reproductive Health Key Laboratory of Zhejiang Province, and Women s Hospital, School of Medicine, Zhejiang University, Xueshi Road 2, Hangzhou, China
Int J Gynecol Cancer 20:1391-8. 2010..The objectives of this study were to identify HPV-16 E6 and E7 variants prevalent in Chinese women and to assess the risk of them for invasive cervical carcinoma and cervical ..
- Subcellular localization of the human papillomavirus 16 E7 oncoprotein in CaSki cells and its detection in cervical adenocarcinoma and adenocarcinoma in situKerstin Dreier
Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria
Virology 409:54-68. 2011b>E7 is the major oncoprotein of high-risk human papillomaviruses (HPV) which causes cervical cancer. To date E7 oncoproteins have not been investigated in cervical adenocarcinoma...
- Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancerJung Wook Park
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Cancer Res 70:9959-68. 2010..In addition, studies have demonstrated an interaction between the HPV16 E7 oncoprotein and the FA pathway, a DNA damage response pathway deficient in FA patients...
- Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in miceSean Jabbar
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Avenue, Madison, WI 53706, USA
Virology 407:60-7. 2010..We found that the HPV-16 E7 oncoprotein was highly potent in causing HNSCC, and its dominance masked any potential oncogenic contribution of E6, ..
- Low- and high-risk human papillomavirus E7 proteins regulate p130 differentlyLisa Barrow-Laing
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
Virology 400:233-9. 2010The E7 protein of high-risk human papillomaviruses (HR HPVs) targets pRb family members (pRb, p107 and p130) for degradation; low-risk (LR) HPV E7 only targets p130 for degradation...
- Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cellsSimon J Allison
Yorkshire Cancer Research P53 Research Unit, Department of Biology, University of York, York YO105DD, UK
Aging (Albany NY) 1:316-27. 2009..g. HPV type16). Viral oncoproteins HPV E6 and HPV E7 access the cell cycle via cellular p53 and retinoblastoma proteins respectively...
- [Gene characterization of E6 and E7 gene of human papillomavirus of 15 cervical cancer in Beijing]Zhuo Ren
Jilin University 2nd Hospital, Obstetrics and Gynecology Department, Changchun 130042, China
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23:88-90. 2009Conducting the gene characterization of the E6 and E7 gene of human papillomavirus 16 (HPV16) isolated from 15 cases of cervical cancer at Beijing.
- Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1? and VEGF expression in non-small cell lung cancer cellsGang Li
Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, Guangdong, People s Republic of China
Cancer Lett 311:160-70. 2011..We found that overexpression of HPV-16 E6 and E7 oncoproteins in NSCLC cells significantly promoted angiogenesis both in vitro and in vivo, and correspondingly, an ..
- Inhibition of HPV-16 E7 oncogenic activity by HPV-16 E2N Gammoh
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
Oncogene 28:2299-304. 2009Human papillomavirus (HPV) E7 is essential in inducing S-phase progression in differentiating epithelial cells...
- Viral interaction: a possible contributing factor in head and neck cancer progressionMichael P Underbrink
Departments of Otolaryngology, University of Texas Medical Branch, Galveston, TX 77555, USA
Acta Otolaryngol 128:1361-9. 2008Human herpesvirus-8 could potentiate the effects of human papillomavirus (HPV)-16 on cell cycle dysregulation by up-regulating the transcription of HPV-16 E7, which can lead to malignant transformation of normal epithelial cells.
- Multiple interference of the human papillomavirus-16 E7 oncoprotein with the functional role of the metastasis suppressor Nm23-H1 proteinAnna Maria Mileo
Department for the Development of Therapeutic Programs, Laboratory C, Regina Elena Cancer Institute, Centre for Experimental Research, Via delle Messi d Oro 156, 00158, Rome, Italy
J Bioenerg Biomembr 38:215-25. 2006..of the viral genome in the transformed epithelial cells is restricted to the coding regions for the E6 and E7 oncoproteins. Nevertheless, E7 plays the major role in cell transformation...
- Identification of the FHL2 transcriptional coactivator as a new functional target of the E7 oncoprotein of human papillomavirus type 16Beatriz Campo-Fernandez
Tyrolean Cancer Research Institute at the Medical University Innsbruck, 6020 Innsbruck, Austria
J Virol 81:1027-32. 2007We identified the transcriptional coactivator FHL2 as a novel target of the human papillomavirus type 16 (HPV-16) E7 oncoprotein, which plays a major role in cell transformation...
- Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced hostXiao Song Liu
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, Australia
J Immunol 177:2873-9. 2006..This finding demonstrates a strategy for overcoming inhibition of MHC class I epitopes upon immunization of a host already primed to Ag, which may facilitate immunotherapy for chronic viral infection or cancer...
- Regulation of human papillomavirus type 16 E7 activity through direct protein interaction with the E2 transcriptional activatorNoor Gammoh
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34012, Italy
J Virol 80:1787-97. 2006..Uncontrolled activity of the viral oncoproteins E6 and E7 results in the immortalization of the infected epithelial cells and thus prevents the production of mature virions...
- The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationBenyue Zhang
Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, IN 46202, USA
Proc Natl Acad Sci U S A 103:437-42. 2006..g., HPV-6) cause benign hyperproliferative disease. The E7 protein of HPV-16 binds all retinoblastoma tumor suppressor protein (pRB) family members with higher affinity than ..
- Analysis of E7/Rb associationsSandra Caldeira
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
Methods Mol Med 119:363-79. 2005The product of the early gene E7 is one of the major transforming proteins of human papillomaviruses (HPVs)...
- CCAAT/enhancer binding protein beta binds to and activates the P670 promoter of human papillomavirus type 16Iwao Kukimoto
Division of Molecular Genetics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virology 346:98-107. 2006..These results suggest that C/EBPbeta is involved in enhancing transcription from the P670 during keratinocyte differentiation...
- Sequence variation and the transcriptional activity of the upstream regulatory region in human papillomavirus 16 E7 variants in cervical cancer of Korean womenYong Beom Kim
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun Dong, Jongno gu, Seoul 110 744, South Korea
Oncol Rep 14:459-64. 2005..the sequence variation and different transcriptional activities of the upstream regulatory region (URR) in HPV 16 E7 variants in cervical cancer tissue from Korean women...
- Naturally processed and HLA-B8-presented HPV16 E7 epitope recognized by T cells from patients with cervical cancerSebastian Oerke
Department of Medical Microbiology, University of Mainz, Mainz, Germany
Int J Cancer 114:766-78. 2005Several major histocompatibility complex (MHC) alleles have been reported to present peptides derived from the HPV16 E7 oncoprotein to T cells. We describe an overrepresentation of the HLA-B8 allele (28...
- [Induction of human oral carcinoma by human papillomavirus 16 E6/E7 and TPA]Jian Zhao
Department of Obstetrics and Gyneology, First Hospital, Beijing 100036, China
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 17:234-6. 2003To study the effect of human papillomavirus (HPV) 16 E6/E7 and TPA (12-O-tetradecanog-1-phorbol-13-acetate) on malignant transformation of human embryo oral tissue.
- Effect of human papillomavirus type 16 E6 and E7 oncogenes on the activity of the transforming growth factor-beta2 (TGF-beta2) promoterM Murvai
Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Arch Virol 149:2379-92. 2004The effect of the human papillomavirus type 16 (HPV 16) E6 and E7 proteins was studied on the transcriptional activity of the human transforming growth factor beta2 (TGF-beta) promoter in different cell lines...
- Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with ageK M Malcolm
Centre for Immunology and Cancer Research, University of QLD, Princess Alexandra Hospital, Ipswich, Road, Buranda, QLD, 4170 Australia
Clin Dev Immunol 10:91-103. 2003Transgenic mice expressing the E7 protein of HPV16 from the keratin 14 promoter demonstrate increasing thymic hypertrophy with age...
- A negative regulatory element in the human papillomavirus type 16 genome acts at the level of late mRNA stabilityI M Kennedy
Institute of Virology, University of Glasgow, Scotland, United Kingdom
J Virol 65:2093-7. 1991..This indicates that the element acts as an mRNA instability element. The significance of A-rich, GU-rich, and AUG-rich sequences for the functioning of this human papillomavirus type 16 instability element is discussed...
- Protective effect of oxidative stress in HaCaT keratinocytes expressing E7 oncogeneJ H Shim
Laboratory of Cell and Immunobiochemistry, Division of Bioscience and Biotechnology, Konkuk University, Seoul, South Korea
Amino Acids 34:135-41. 2008In a previous study, we established a stable cell line which constitutively expresses E7 in HaCaT human keratinocyte cell line and identified various relevant factors including oxygen modulators affected by the E7 oncogene...
- [Effects of human papillomavirus 16 E6 and E7 oncogene on the proliferation and differentiation of human laryngeal squamous cell carcinoma cell line]Ping Cai
Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan 430079, China
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42:774-8. 2007..the correlation between HPV16 and the development of laryngeal squamous cell carcinoma by studying the effects of HPV16 E6 and E7 oncogene on the proliferation and differentiation of human laryngeal squamous carcinoma cell line.
- DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residuesYuh Jin Liang
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, ROC
Int J Biochem Cell Biol 40:2431-41. 2008..Subsequent to viral infection, the constitutive expression of the viral oncoproteins E6 and E7 plays a number of critical roles in maintaining the transformed phenotype...
- TGF-beta1 and IL-4 downregulate human papillomavirus-16 oncogene expression but have differential effects on the malignant phenotype of cervical carcinoma cellsManuela Donalisio
Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Turin, Italy
Virus Res 132:253-6. 2008..Results indicated that downregulation of E6 and E7 levels by IL-4 in CaSki cells is weaker than that exerted by TGF-beta1, a known LCR inhibitor, although both ..
- ErbB-2 receptor cooperates with E6/E7 oncoproteins of HPV type 16 in breast tumorigenesisAmber Yasmeen
Montreal Center for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec H3T 1E2 Canada
Cell Cycle 6:2939-43. 2007..Recently, we reported that ErbB-2 cooperates with E6/E7 oncoproteins of HPV type 16 to induce neoplastic transformation of human normal oral epithelial cells...
- Mutation in the immunodominant epitope of the HPV16 E7 oncoprotein as a mechanism of tumor escapeMichal Smahel
Department of Experimental Virology, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic
Cancer Immunol Immunother 57:823-31. 2008..escape of tumor cells infected with HPV16, we previously used mouse oncogenic TC-1 cells producing HPV16 E6 and E7 oncoproteins to derive TC-1 clones resistant to immunization against E7...
- Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteinsGary A Clawson
Department of Pathology, the Gittlen Cancer Research Foundation, The Pennsylvania State University, Hershey Medical Center, Hershey, Pennsylvania, USA
J Cell Biochem 105:81-8. 2008..Further, expression of HPV E6/E7 proteins is associated with a post-transcriptional up-regulation of HtrA1 (most notably the nuclear form), and HtrA1 ..
- Human papillomavirus type 16 E7 oncoprotein inhibits apoptosis mediated by nuclear insulin-like growth factor-binding protein-3 by enhancing its ubiquitin/proteasome-dependent degradationFrédéric R Santer
Cell Metabolism and Differentiation Research Group, Rennweg 10, 6020 Innsbruck, Austria
Carcinogenesis 28:2511-20. 2007The E7 protein encoded by the oncogenic human papillomavirus type 16 has been shown to bind and inactivate insulin-like growth factor-binding protein-3 (IGFBP-3), the pro-apoptotic product of a tumour suppressor gene; however, the ..
- The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cellsNicole Spardy
Biochemistry and Molecular Genetics Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Virol 81:13265-70. 2007..We found that FA pathway activation is triggered mainly by the HPV type 16 (HPV-16) E7 oncoprotein and is associated with an enhanced formation of large FANCD2 foci and recruitment of FANCD2 as well as ..
- Human papillomavirus type 16 P670 promoter is negatively regulated by CCAAT displacement proteinKaori Sato
Center for Pathogen Genomics, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Virus Genes 35:473-81. 2007..The data strongly suggest that CDP acts as a major suppressor for P670 transcription by binding to the promoter region in the undifferentiated cells and even in the partially differentiated cells that express the activator hSkn-1a...
- CTL responses to a DNA vaccine encoding E7 gene of human papillomavirus type 16 from an Iranian isolateZahra Meshkat
Department of Virology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Iran J Immunol 5:82-91. 2008..The early HPV type 16 genes, E6 and E7, directly participate in the in vitro transformation of primary human keratinocytes and represent an excellent ..
- Characterization of a new type HPV16 E7 variant isolated from cervical cancer highest incidence area in Hubei Province of ChinaHui Li
Department of Molecular Biology, Institute of Virology, Wuhan University Medical School, Wuhan 430071, P R China
Eksp Onkol 26:48-54. 2004To investigate the variation and biological properties of HPV16 E7 isolated from cervical cancer biopsy samples from highest incidence area in HuBei province of China.
- Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancersAgnes Burniat
Institute of Interdisciplinary Research, School of Medicine, Department of Endocrinology, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
Endocrinology 149:5107-17. 2008We studied gene expression profiles in two mouse models of human thyroid carcinoma: the Tg-RET/PTC3 (RP3) and Tg-E7 mice...
- HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alphaRosa A Cardone
Department of General and Environmental Physiology, University of Bari, Bari, Italy
PLoS ONE 3:e3529. 2008..and a cell line in which transformation can be turned on and followed by the inducible expression of the E7 oncogene of human papillomavirus type 16 (HPV16), that intracellular alkalinization is an early and essential ..
- Human papillomavirus type 16 E7 protein increases acetylation of histone H3 in human foreskin keratinocytesBenyue Zhang
Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
Virology 329:189-98. 2004..Human papillomavirus type 16 (HPV16) E7 can inactivate retinoblastoma protein (pRB), which recruits histone deacetylases, and also physically interacts with ..
- Human papillomavirus type 16 DNA sequenceK Seedorf
Virology 145:181-5. 1985..The sequence reveals an interruption of the reading frame coding for a suspected E1 protein...
- Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosisHuidong Yuan
Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Oncogene 24:5069-78. 2005Inhibition of apoptosis plays an important role in the cellular immortalization and transformation induced by E6 and E7 oncoproteins of human papillomavirus (HPV)...
- Human papillomavirus E7 protein deregulates mitosis via an association with nuclear mitotic apparatus protein 1Christine L Nguyen
Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 83:1700-7. 2009We previously observed that high-risk human papillomavirus type 16 (HPV16) E7 expression leads to the delocalization of dynein from mitotic spindles (C. L. Nguyen, M. E. McLaughlin-Drubin, and K. Munger, Cancer Res. 68:8715-8722, 2008)...
- Human papillomavirus causes an angiogenic switch in keratinocytes which is sufficient to alter endothelial cell behaviorW Chen
Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
Virology 367:168-74. 2007..We have previously reported that expression of human papillomavirus type 16 E6 and E7 (HPV16 E6E7) proteins in primary foreskin keratinocytes (HFKs) decreases expression of two inhibitors and increases ..
- Human papillomavirus type 16 E6/E7 upregulation of nucleophosmin is important for proliferation and inhibition of differentiationRachel McCloskey
Centre for Cancer Research and Cell Biology, Queen s University, Belfast BT9 7BL, United Kingdom
J Virol 84:5131-9. 2010The E6 and E7 oncoproteins of high-risk human papillomaviruses (HPVs) are together sufficient to cause cellular transformation...
- Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cellsMichał W Luczak
Poznan University of Medical Sciences, Department of Biochemistry and Molecular Biology, 6 Swiecickiego Street, 60 781 Poznan, Poland
Cancer Lett 272:53-60. 2008..The HPV oncogenic proteins E6 and E7 are able to inactivate p53 and Rb proteins, which results in malignant transformation...
- E6 and E7 oncoproteins from human papillomavirus type 16 induce activation of human transforming growth factor beta1 promoter throughout Sp1 recognition sequenceOscar Peralta-Zaragoza
Division of Molecular Biology of Pathogens, National Institute of Public Health, Cuernavaca, Mexico
Viral Immunol 19:468-80. 2006Human Papillomavirus (HPV) infection is the main etiologic agent of cervical cancer and HPV E6 and E7 oncogenes trans-regulate many cellular genes...
- Effects of HPV-16 E5, E6 and E7 proteins on survival, adhesion, migration and invasion of trophoblastic cellsSelma Boulenouar
Research Laboratory on Human Reproduction, Universite Libre de Bruxelles, Route de Lennik 808, CP636, B 1070 Brussels, Belgium
Carcinogenesis 31:473-80. 2010..In the present work, we analyzed the impacts of HPV-16 E5, E6 and E7 oncoproteins on the trophoblastic model...
- Expression of human papillomavirus type 16 E7 oncoprotein alters keratinocytes expression profile in response to tumor necrosis factor-alphaEnrique Boccardo
Virology Group, Ludwig Institute for Cancer Research, São Paulo 01323 903, Brazil
Carcinogenesis 31:521-31. 2010Acute expression of E7 oncogene from human papillomavirus (HPV) 16 or HPV18 is sufficient to overcome tumor necrosis factor (TNF)-alpha cytostatic effect on primary human keratinocytes...
- An RNA Sensor for Detection of Circulating Tumor CellsGary Clawson; Fiscal Year: 2007..Successful development of this RNA Sensor would provide a major advantage over PCR-based assays, and could form the basis for high-throughput screening tests for simultaneous detection of many different circulating tumor cell types. ..