PTTH

Summary

Gene Symbol: PTTH
Description: prothoracicotropic hormone
Alias: PTTH-KS, prothoracicotropic hormone, prothoracicotropic hormone Kinshu Showa
Species: domestic silkworm

Top Publications

  1. Ishibashi J, Kataoka H, Isogai A, Kawakami A, Saegusa H, Yagi Y, et al. Assignment of disulfide bond location in prothoracicotropic hormone of the silkworm, Bombyx mori: a homodimeric peptide. Biochemistry. 1994;33:5912-9 pubmed
    The disulfide bond location of a homodimeric peptide, prothoracicotropic hormone (PTTH) of the silkworm, Bombyx mori, was determined by a combination of partial reduction and sequence analysis of peptide fragments generated through a ..
  2. Gu S, Lin J, Lin P. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca(2+)/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56:93-101 pubmed publisher
    Our previous studies showed that the prothoracicotropic hormone (PTTH) stimulated extracellular signal-regulated kinase (ERK) phosphorylation in prothoracic glands of Bombyx mori both in vitro and in vivo...
  3. Ohtsuka K, Atsumi T, Fukushima Y, Shiomi K. Identification of a cis-regulatory element that directs prothoracicotropic hormone gene expression in the silkworm Bombyx mori. Insect Biochem Mol Biol. 2011;41:356-61 pubmed publisher
    In the silkworm Bombyx mori and other insects, prothoracicotropic hormone (PTTH) plays a central role in controlling molting and metamorphosis by stimulating the prothoracic glands to synthesize and release the molting hormone ecdysone...
  4. Uno T, Sakamoto K, Isoyama Y, Hiragaki S, Uno Y, Kanamaru K, et al. Relationship between the expression of Rab family GTPases and neuropeptide hormones in the brain of Bombyx mori. Histochem Cell Biol. 2013;139:299-308 pubmed publisher
    ..Rab1 and Rab7 co-localized with eclosion hormone. Rab1 co-localized with prothoracicotropic hormone. These results suggest that Rab1, Rab7 and Rab14 may be involved in neuropeptide transport in the brain ..
  5. Wei Z, Yu M, Tang S, Yi Y, Hong G, Jiang S. Transcriptional regulation of the gene for prothoracicotropic hormone in the silkworm, Bombyx mori. Mol Biol Rep. 2011;38:1121-7 pubmed publisher
    b>Prothoracicotropic hormone (PTTH) is one of key players in regulation of insect growth, molting, metamorphosis, diapause, and is expressed specifically in the two pairs of lateral PTTH-producing neurosecretory cells in the brain...
  6. Lin J, Gu S. Prothoracicotropic hormone induces tyrosine phosphorylation in prothoracic glands of the silkworm, Bombyx mori. Arch Insect Biochem Physiol. 2011;76:144-55 pubmed publisher
    ..Results showed that prothoracicotropic hormone (PTTH) stimulates a rapid increase in tyrosine phosphorylation of at least 2 proteins in prothoracic ..
  7. Jenni S, Goyal Y, von Grotthuss M, Shvartsman S, Klein D. Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso. Mol Cell. 2015;60:941-52 pubmed publisher
    In insects, brain-derived Prothoracicotropic hormone (PTTH) activates the receptor tyrosine kinase (RTK) Torso to initiate metamorphosis through the release of ecdysone...
  8. Gu S, Young S, Lin J, Lin P. Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2011;41:197-202 pubmed publisher
    The prothoracicotropic hormone (PTTH) stimulates ecdysteroidogenesis by prothoracic gland in larval insects...
  9. Gu S, Hsieh Y, Lin P. Stimulation of orphan nuclear receptor HR38 gene expression by PTTH in prothoracic glands of the silkworm, Bombyx mori. J Insect Physiol. 2016;90:8-16 pubmed publisher
    A complex signaling network appears to be involved in prothoracicotropic hormone (PTTH)-stimulated ecdysteroidogenesis in insect prothoracic glands (PGs). Less is known about the genomic action of PTTH signaling...

More Information

Publications14

  1. Kataoka H, Nagasawa H, Isogai A, Ishizaki H, Suzuki A. Prothoracicotropic hormone of the silkworm, Bombyx mori: amino acid sequence and dimeric structure. Agric Biol Chem. 1991;55:73-86 pubmed
    b>Prothoracicotropic hormone (PTTH) of the silkworm, Bombyx mori, was purified and its primary structure determined for the most part...
  2. Kawakami A, Kataoka H, Oka T, Mizoguchi A, Kimura Kawakami M, Adachi T, et al. Molecular cloning of the Bombyx mori prothoracicotropic hormone. Science. 1990;247:1333-5 pubmed
    b>Prothoracicotropic hormone (PTTH), a brain secretory polypeptide of insects, stimulates the prothoracic glands to produce and release ecdysone, the steroid essential to insect development...
  3. Adachi Yamada T, Iwami M, Kataoka H, Suzuki A, Ishizaki H. Structure and expression of the gene for the prothoracicotropic hormone of the silkmoth Bombyx mori. Eur J Biochem. 1994;220:633-43 pubmed
    We cloned and characterized two allelic variants of the gene for the Bombyx mori prothoracicotropic hormone (PTTH), a homodimeric 30-kDa brain secretory protein...
  4. Gu S, Hsieh Y, Lin P. Signaling involved in PTTH-stimulated 4E-BP phosphorylation in prothoracic gland cells of Bombyx mori. J Insect Physiol. 2017;96:1-8 pubmed publisher
    ..5'-monophosphate-activated protein kinase (AMPK)/the target of rapamycin (TOR) signaling is involved in prothoracicotropic hormone (PTTH)-stimulated ecdysteroidogenesis in Bombyx mori prothoracic glands (PGs)...
  5. Gu S, Yeh W, Young S, Lin P, Li S. TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2012;42:296-303 pubmed publisher
    The prothoracicotropic hormone (PTTH) is a stimulator of ecdysteroidogenesis in prothoracic gland of larval insects...