Gene Symbol: Ano1
Description: anoctamin 1
Alias: anoctamin-1, Ca-activated chloride channel Tmem16A, anoctamin 1, calcium activated chloride channel
Species: Domestic guinea pig

Top Publications

  1. He Q, Halm S, Zhang J, Halm D. Activation of the basolateral membrane Cl- conductance essential for electrogenic K+ secretion suppresses electrogenic Cl- secretion. Exp Physiol. 2011;96:305-16 pubmed publisher
    ..Maximal physiological Cl(-) secretion occurs only for synergistic activation mechanisms that close these basolateral membrane Cl(-) channels...
  2. Gallos G, Remy K, Danielsson J, Funayama H, Fu X, Chang H, et al. Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2013;305:L625-34 pubmed publisher
    ..The TMEM16 family may provide a novel therapeutic target for limiting airway constriction in asthma. ..
  3. Kondo M, Tsuji M, Hara K, Arimura K, Yagi O, Tagaya E, et al. Chloride ion transport and overexpression of TMEM16A in a guinea-pig asthma model. Clin Exp Allergy. 2017;47:795-804 pubmed publisher
    ..TMEM16A inhibitors may be useful for the treatment of hyper-secretion in asthma. ..