Gene Symbol: TJP2
Description: tight junction protein 2
Alias: ZO-2, tight junction protein ZO-2, zona occludens 2, zona occludens protein 2, zonula occludens protein 2
Species: dog
Products:     TJP2

Top Publications

  1. Traweger A, Fuchs R, Krizbai I, Weiger T, Bauer H, Bauer H. The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B. J Biol Chem. 2003;278:2692-700 pubmed
    ..Interestingly, no association of SAF-B with ZO-1 was found, which supports the notion that junctional MAGUKs serve nonredundant functions. ..
  2. Gonzalez Mariscal L, Ponce A, Alarcón L, Jaramillo B. The tight junction protein ZO-2 has several functional nuclear export signals. Exp Cell Res. 2006;312:3323-35 pubmed
    ..Moreover, the transfection of MDCK cells with full-length ZO-2 revealed that the mutation of any of the NES present in the molecule was sufficient to induce nuclear accumulation of the protein. ..
  3. Hernandez S, Chavez Munguia B, Gonzalez Mariscal L. ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture. Exp Cell Res. 2007;313:1533-47 pubmed
  4. Traweger A, Lehner C, Farkas A, Krizbai I, Tempfer H, Klement E, et al. Nuclear Zonula occludens-2 alters gene expression and junctional stability in epithelial and endothelial cells. Differentiation. 2008;76:99-106 pubmed
  5. Tapia R, Huerta M, Islas S, Avila Flores A, Lopez Bayghen E, Weiske J, et al. Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle. Mol Biol Cell. 2009;20:1102-17 pubmed publisher
    ..These results thus explain why in confluent quiescent epithelia ZO-2 is absent from the nucleus and localizes at the cellular borders, whereas in sparse proliferating cultures ZO-2 is conspicuously present at the nucleus. ..
  6. Chamorro D, Alarcón L, Ponce A, Tapia R, Gonzalez Aguilar H, Robles Flores M, et al. Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation. Mol Biol Cell. 2009;20:4120-9 pubmed publisher
    ..These results constitute novel information for understanding the mechanisms that regulate the intracellular fate of ZO-2. ..
  7. Jesaitis L, Goodenough D. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994;124:949-61 pubmed
    ..Nagafuchi, S. Tsukita, and Sh. Tsukita. 1991. J. Cell Biol. 115:1449-1462). Thus it appears that ZO-2 is not a component of the fascia adherens, and that unlike ZO-1, this protein is restricted to the epithelial tight junction. ..
  8. Lechuga S, Alarcón L, Solano J, Huerta M, Lopez Bayghen E, Gonzalez Mariscal L. Identification of ZASP, a novel protein associated to Zona occludens-2. Exp Cell Res. 2010;316:3124-39 pubmed publisher
    ..ZASP over-expression blocks the inhibitory activity of ZO-2 on cyclin D1 gene transcription and protein expression. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds. ..
  9. Beatch M, Jesaitis L, Gallin W, Goodenough D, Stevenson B. The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region. J Biol Chem. 1996;271:25723-6 pubmed
    ..This suggests that the C-terminal ends of ZO-1 and ZO-2 have different functions. ..

More Information


  1. Unda F, Perez Nanclares G, Le Morvan V, Hernandez C, Vilaxa A, de la Fuente M, et al. Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin during mouse tooth development. Histol Histopathol. 2003;18:27-38 pubmed publisher
    ..The occurrence and relation during tooth development of tight junction proteins ZO-1, ZO-2 and occludin, but not ZO-3, suggests a combinatory assembly in tooth morphogenesis and cell differentiation. ..
  2. Remue E, Meerschaert K, Oka T, Boucherie C, Vandekerckhove J, Sudol M, et al. TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner. FEBS Lett. 2010;584:4175-80 pubmed publisher
    ..We propose that zonula occludens is a negative regulator of TAZ and suggest that selected tight junction proteins control nuclear translocation and activity of TAZ...
  3. Raya Sandino A, Castillo Kauil A, Domínguez Calderón A, Alarcón L, Flores Benitez D, Cuellar Perez F, et al. Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. Biochim Biophys Acta Mol Cell Res. 2017;1864:1714-1733 pubmed publisher
    ..Hence, ZO-2 is a crucial regulator of Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. ..
  4. Fanning A, Van Itallie C, Anderson J. Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia. Mol Biol Cell. 2012;23:577-90 pubmed publisher
  5. Quirós M, Alarcón L, Ponce A, Giannakouros T, Gonzalez Mariscal L. The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257. Mol Biol Cell. 2013;24:2528-43 pubmed publisher
    b>Zona occludens 2 (ZO-2) has a dual localization. In confluent epithelia, ZO-2 is present at tight junctions (TJs), whereas in sparse proliferating cells it is also found at the nucleus...
  6. Wetzel F, Mittag S, Cano Cortina M, Wagner T, Kramer O, Niedenthal R, et al. SUMOylation regulates the intracellular fate of ZO-2. Cell Mol Life Sci. 2017;74:373-392 pubmed publisher
    ..From these data we conclude that SUMOylation affects the intracellular localization of ZO-2 and its regulatory role on GSK3? and ?-catenin signaling activity. ..