Gene Symbol: TIMP2
Description: TIMP metallopeptidase inhibitor 2
Alias: metalloproteinase inhibitor 2, TIMP-2, tissue inhibitor of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-2, tissue inhibitor of metalloproteinases 2
Kang J, Kang K, Koo H, Park J, Choi E, Park Y. Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells. Stem Cells Dev. 2008;17:681-93 pubmed publisher
..Therefore, it is suggested that cAD-MSCs have a potential therapeutic use in the treatment of immune-mediated disease. ..
Campbell S, Nasir L, Argyle D, Gault E, Duthie S, Bennett D. Cloning of canine IL-1ra, TNFR and TIMP-2. Vet Immunol Immunopathol. 2001;78:207-14 pubmed
..All three canine proteins IL-1ra, TNFR/ECD and TIMP-2 (177, 211 and 221 amino acids, respectively) showed considerable sequence similarity with the homologous sequences published for other species. ..
Newman R, Kitchell B, Wallig M, Paria B. The cloning and expression of matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase 2 in normal canine lymph nodes and in canine lymphoma. Res Vet Sci. 2008;84:206-14 pubmed
Matrix metalloproteinase-2 (MMP-2) and its inhibitor, tissue inhibitor of matrix metalloproteinase 2 (TIMP2), are known to be important in cancer...
Giantin M, Aresu L, Benali S, Aric A, Morello E, Martano M, et al
. Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases and vascular endothelial growth factor in canine mast cell tumours. J Comp Pathol. 2012;147:419-29 pubmed publisher
..This study demonstrates that MMP-9, TIMP-2 and VEGF-A expression is related to histological grade and suggests that these markers are possible indicators of malignancy and targets for therapeutic strategies...
Wu Z, Zang S, Liu W, Jiang N, Yang W. Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2. Vasc Endovascular Surg. 2015;49:135-41 pubmed publisher
..Our study suggests cryoplasty might increase the expression of TIMP-2 and decrease the expression of MMP-2, thereby inhibiting vascular hyperplasia and collagen fibers synthesis of the stenotic vessels. ..
Wang J, Li J, Liu H, Yi S, Su G, Zhang Y, et al
. Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine. Mol Cell Biochem. 2014;391:259-66 pubmed publisher
..Maneuvers managed to modulate Cx43 level or normalize the balance of MMP-2/TIMP-2 are promising to ameliorate prognosis of VF. ..