Gene Symbol: SRC
Description: SRC proto-oncogene, non-receptor tyrosine kinase
Alias: proto-oncogene tyrosine-protein kinase Src, src oncogene, tyrosine protein kinase pp60-c-src, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Species: dog
Products:     SRC

Top Publications

  1. Palacios F, Tushir J, Fujita Y, D SOUZA SCHOREY C. Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions. Mol Cell Biol. 2005;25:389-402 pubmed
    ..Here we demonstrate that, upon v-Src expression, a potent trigger of epithelial to mesenchymal transitions, E-cadherin is internalized and then shuttled ..
  2. Mettlen M, Platek A, Van Der Smissen P, Carpentier S, Amyere M, Lanzetti L, et al. Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells. Traffic. 2006;7:589-603 pubmed
    We addressed the role of Src on cortical actin dynamics and polarized endocytosis in MDCK cells harboring a thermosensitive v-src mutant...
  3. Fan S, Meng Q, Laterra J, Rosen E. Role of Src signal transduction pathways in scatter factor-mediated cellular protection. J Biol Chem. 2009;284:7561-77 pubmed publisher
    ..Here we studied Src signaling pathways involved in SF cell protection...
  4. Medts T, de Diesbach P, Cominelli A, N kuli F, Tyteca D, Courtoy P. Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes. Exp Cell Res. 2010;316:3239-53 pubmed publisher
    b>Src, a non-receptor tyrosine kinase, is a key signal transduction partner of epidermal growth factor (EGF) receptor (EGFR). In human breast cancer, EGFR and Src are frequently over-expressed and/or over-activated...
  5. Montaseri A, Büsch F, Mobasheri A, Buhrmann C, Aldinger C, Rad J, et al. IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. PLoS ONE. 2011;6:e28663 pubmed publisher
    ..inhibitory effects of IGF-1 or/and PDGF-bb on IL-1β-induced NF-κB activation were sensitive to inhibitors of Src (PP1), PI-3K (wortmannin) and Akt (SH-5), suggesting that the pathway consisting of non-receptor tyrosine kinase (..