Gene Symbol: RAB7A
Description: RAB7A, member RAS oncogene family
Alias: RAB7, ras-related protein Rab-7a, GTP-binding protein (rab7), RAB7, member RAS oncogene family
Raiborg C, Wenzel E, Pedersen N, Olsvik H, Schink K, Schultz S, et al
. Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Nature. 2015;520:234-8 pubmed publisher
..and neurite outgrowth, forms contact sites with late endosomes (LEs) via coincident detection of the small GTPase RAB7 and phosphatidylinositol 3-phosphate (PtdIns(3)P)...
Ceresa B, Bahr S. rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome. J Biol Chem. 2006;281:1099-106 pubmed
..We examined the role of the small molecular weight guanine nucleotide-binding protein (G-protein) rab7 as a regulator of the distal stages of the endocytic pathway...
Romero Rosales K, Peralta E, Guenther G, Wong S, Edinger A. Rab7 activation by growth factor withdrawal contributes to the induction of apoptosis. Mol Biol Cell. 2009;20:2831-40 pubmed publisher
The Rab7 GTPase promotes membrane fusion reactions between late endosomes and lysosomes. In previous studies, we demonstrated that Rab7 inactivation blocks growth factor withdrawal-induced cell death...
Pavlos N, Gr Nborg M, Riedel D, Chua J, Boyken J, Kloepper T, et al
. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci. 2010;30:13441-53 pubmed publisher
..Finally, we demonstrate that selective modulation of the GTP/GDP switch mechanism of Rab27b impairs SV recycling, suggesting that Rab27b, probably in concert with Rab3s, is involved in SV exocytosis...
Chavrier P, Parton R, Hauri H, Simons K, Zerial M. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell. 1990;62:317-29 pubmed
..second, rab5, is located at the cytoplasmic surface of the plasma membrane and on early endosomes, while the third, rab7, is found on late endosomes...
Chavrier P, Vingron M, Sander C, Simons K, Zerial M. Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line. Mol Cell Biol. 1990;10:6578-85 pubmed
..This diversity supports their proposed function in controlling different steps in membrane traffic. ..
Feng Y, Press B, Wandinger Ness A. Rab 7: an important regulator of late endocytic membrane traffic. J Cell Biol. 1995;131:1435-52 pubmed
Rab5 and rab7 proteins belong to a superfamily of small molecular weight GTPases known to be associated with early and late endosomes, respectively...
Cao Z, Li C, Higginbotham J, Franklin J, Tabb D, Graves Deal R, et al
. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics. 2008;7:1651-67 pubmed publisher