PTGS2

Summary

Gene Symbol: PTGS2
Description: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Alias: COX-2, cyclooxygenase type 2, prostaglandin G/H synthase 2, prostaglandin G/H synthase-2
Species: dog

Publications

  1. Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro
    Djamila Boutemmine
    Centre de Recherche en Reproduction Animale, Faculté de Médecine Vétérinaire, Université de Montréal, Saint Hyacinthe, Québec, Canada J2S 7C6
    Endocrinology 143:1134-43
  2. COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers
    F Millanta
    Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Pisa, Italy
    Breast Cancer Res Treat 98:115-20
  3. Cyclooxygenase-2 expression in normal and neoplastic canine mammary cell lines
    M Brunelle
    Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, C P 5000, St Hyacinthe, Québec J2S 7C6, Canada
    Vet Pathol 43:656-66
  4. Expression of cyclooxygenase-2, P-glycoprotein and multi-drug resistance-associated protein in canine transitional cell carcinoma
    J Y Lee
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Res Vet Sci 83:210-6
  5. Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation
    Chen Li Lai
    Department of Clinical Sciences of Companion Animals, University of Utrecht, Utrecht, The Netherlands
    J Vet Intern Med 21:776-82
  6. Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis
    Ting Ting Hong
    Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    Am J Physiol Heart Circ Physiol 294:H145-55
  7. Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells
    Jung Won Kang
    Department of Microbiology, College of Veterinary Medicine and Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
    Stem Cells Dev 17:681-93
  8. PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling
    Daniela Steinert
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    Am J Physiol Cell Physiol 296:C75-87

Scientific Experts

  • Erik Teske
  • Daniela Steinert
  • Ting Ting Hong
  • Jung Won Kang
  • Chen Li Lai
  • J Y Lee
  • M Brunelle
  • F Millanta
  • Djamila Boutemmine
  • Helmut Bartels
  • Franz X Beck
  • Wolfgang Neuhofer
  • Kyung Sun Kang
  • Hye Cheong Koo
  • Benedict R Lucchesi
  • Eun Wha Choi
  • Yong Ho Park
  • Ting-Ting Hong
  • Jeong Ran Park
  • Jinbao Huang
  • Terrance D Barrett
  • Kyung-Sun Kang
  • S Tanabe
  • H Inokuma
  • T Oomachi
  • S Azuma
  • Y Kobayashi
  • K Ogihara
  • H Shimohira
  • Frederick van Sluijs
  • J-Y Lee
  • Jan Mol
  • L G Wolfe
  • S Citi
  • J Sirois
  • M Porciani
  • A Poli
  • E A Sartin
  • D Della Santa
  • Jean Sirois
  • Derek Boerboom
  • Alan K Goff
  • Nadine Bouchard
  • Helen E Jones

Detail Information

Publications8

  1. Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro
    Djamila Boutemmine
    Centre de Recherche en Reproduction Animale, Faculté de Médecine Vétérinaire, Université de Montréal, Saint Hyacinthe, Québec, Canada J2S 7C6
    Endocrinology 143:1134-43
    ..Thus, this study characterizes for the first time the structure of canine PGHS-2 and provides an in vitro model to unravel the molecular basis of PGHS-2 expression in prostatic adenocarcinomas...
  2. COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers
    F Millanta
    Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Pisa, Italy
    Breast Cancer Res Treat 98:115-20
    ..In the canine species, moreover, COX-2 may be important for mediating HER-2 induced mammary tumors...
  3. Cyclooxygenase-2 expression in normal and neoplastic canine mammary cell lines
    M Brunelle
    Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, C P 5000, St Hyacinthe, Québec J2S 7C6, Canada
    Vet Pathol 43:656-66
    ....
  4. Expression of cyclooxygenase-2, P-glycoprotein and multi-drug resistance-associated protein in canine transitional cell carcinoma
    J Y Lee
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada cho, Obihiro, Hokkaido 080 8555, Japan
    Res Vet Sci 83:210-6
    ..043). These results suggest that P-gp expression is induced by overexpression of COX-2 in canine patients with TCC...
  5. Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation
    Chen Li Lai
    Department of Clinical Sciences of Companion Animals, University of Utrecht, Utrecht, The Netherlands
    J Vet Intern Med 21:776-82
    ..This conclusion is further supported by the finding that the cytokines TNF-alpha and IL-6 and their involved signaling pathways do not stimulate COX-2 expression in malignant canine prostate cells...
  6. Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis
    Ting Ting Hong
    Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    Am J Physiol Heart Circ Physiol 294:H145-55
    ....
  7. Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells
    Jung Won Kang
    Department of Microbiology, College of Veterinary Medicine and Adult Stem Cell Research Center, Seoul National University, Seoul, Republic of Korea
    Stem Cells Dev 17:681-93
    ..Therefore, it is suggested that cAD-MSCs have a potential therapeutic use in the treatment of immune-mediated disease...
  8. PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling
    Daniela Steinert
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    Am J Physiol Cell Physiol 296:C75-87
    ....