PTEN

Summary

Gene Symbol: PTEN
Description: phosphatase and tensin homolog
Alias: MMAC1, homolog of human mutated in multiple advanced cancers, mutated in multiple advanced cancers, phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
Species: dog
Products:     PTEN antibody

Publications

  1. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62
  2. Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma
    E B Dickerson
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    Vet Pathol 42:618-32
  3. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance
    Pei yin Lin
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA, USA
    Mol Cancer 6:16
  4. Expression and significance of PTEN in canine mammary gland tumours
    Changwei Qiu
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Res Vet Sci 85:383-8
  5. Expression and significance of PTEN and VEGF in canine mammary gland tumours
    C W Qiu
    College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    Vet Res Commun 32:463-72
  6. PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle
    Marie Feron
    CNRS UMR6204, Laboratoire de Biotechnologie, Université de Nantes, F 44322 Nantes Cedex 3, France
    Am J Pathol 174:1459-70

Scientific Experts

  • P A Steck
  • Pei-Yin Lin
  • Marie Feron
  • C W Qiu
  • Changwei Qiu
  • E B Dickerson
  • Lynn A Megeney
  • Laurence Dubreil
  • Marie Claire Arnaud
  • Yan Cherel
  • Mireille Ledevin
  • Karl Rouger
  • Vehary Sakanyan
  • Laetitia Guevel
  • Jinqiu Wang
  • Degui Lin
  • C Y Li
  • J Q Wang
  • G Z Deng
  • D G Lin
  • Lei Wang
  • J F Modiano
  • S P Fosmire
  • J W Wojcieszyn
  • A R Lamerato Kozicki
  • R Thomas
  • S R Bianco
  • S C Helfand
  • A R Lamerato-Kozicki
  • M Breen

Detail Information

Publications7

  1. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62
    ..We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA...
  2. Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma
    E B Dickerson
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    Vet Pathol 42:618-32
    We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma)...
  3. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance
    Pei yin Lin
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA, USA
    Mol Cancer 6:16
    BACKGROUND: The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and difficult to ..
  4. Expression and significance of PTEN in canine mammary gland tumours
    Changwei Qiu
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Res Vet Sci 85:383-8
    ..expression and clinical importance of the anti-oncogene phosphatase and tensin homologue deleted on chromosome 10 (PTEN) in canine mammary gland tumours, PTEN expression was compared in 50 cases of canine mammary tumour and four ..
  5. Expression and significance of PTEN and VEGF in canine mammary gland tumours
    C W Qiu
    College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    Vet Res Commun 32:463-72
    To investigate the relationship between the expression of the PTEN (phosphatase and tensin homolog deleted on chromosometen) and VEGF (vascular endothelial growth factor) and the clinicopathological features in canine mammary gland ..
  6. PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle
    Marie Feron
    CNRS UMR6204, Laboratoire de Biotechnologie, Université de Nantes, F 44322 Nantes Cedex 3, France
    Am J Pathol 174:1459-70
    ..exhibiting a cytosolic accumulation of Akt1, GSK3beta, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (PTEN), an enzyme counteracting PI3K-mediated Akt activation...