Gene Symbol: PRKCA
Description: protein kinase C alpha
Alias: protein kinase C alpha type
Padovano V, Massari S, Mazzucchelli S, Pietrini G. PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells. Am J Physiol Cell Physiol. 2009;297:C835-44 pubmed publisher
..Taken together, our data indicate that PKC activity regulates EAAC1 surface density in MDCK cells by inducing its internalization and retention in PKCalpha-labeled recycling endosomes common to apical and basolateral proteins. ..
K ck K, Koenen A, Giese B, Fraunholz M, May K, Siegmund W, et al
. Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J Biol Chem. 2010;285:11336-47 pubmed publisher
..Furthermore, internalization could be shown in an ex vivo placenta perfusion. Our findings represent a new, rapid mechanism in regulation of human OATPs...
Espenel C, Acharya B, Kreitzer G. A biosensor of local kinesin activity reveals roles of PKC and EB1 in KIF17 activation. J Cell Biol. 2013;203:445-55 pubmed publisher
..Furthermore, we show that EB1 recruits KIF17 to dynamic MTs, enabling its accumulation at MT ends and thus promoting MT stabilization at discrete cellular domains. ..
Li X, Yang B, Chen M, Klein J, Sands J, Chen G. Activation of protein kinase C-Î± and Src kinase increases urea transporter A1 Î±-2, 6 sialylation. J Am Soc Nephrol. 2015;26:926-34 pubmed publisher
Obara K, Mitate A, Nozawa K, Watanabe M, Ito Y, Nakayama K. Interactive role of protein phosphatase 2A and protein kinase Calpha in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery. J Vasc Res. 2010;47:115-27 pubmed publisher
..The present results suggest that activation of PKCalpha mediated by an inhibitor of PP2A is involved in the stretch-induced triphosphorylation of MLC(20), and that this triphosphorylation counteracts the stretch-induced contraction. ..
Hong S, Osborne T, Ren L, Briggs J, Mazcko C, Burkett S, et al
. Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells. Vet Comp Oncol. 2011;9:207-18 pubmed publisher
..Finally, both ezrin phosphorylation and cell migration were inhibited using a PKC inhibitor. These data suggest that an association between PKC-mediated activation of ezrin and the metastatic phenotype in canine OS cells. ..