Gene Symbol: NFKB1
Description: nuclear factor kappa B subunit 1
Alias: nuclear factor NF-kappa-B p105 subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
Kojima K, Fujino Y, Goto Koshino Y, Ohno K, Tsujimoto H. Analyses on activation of NF-?B and effect of bortezomib in canine neoplastic lymphoid cell lines. J Vet Med Sci. 2013;75:727-31 pubmed
Ishikawa S, Takemitsu H, Li G, Mori N, Yamamoto I, Arai T. Short communication: molecular characterization of dog and cat p65 subunits of NF-kappaB. Res Vet Sci. 2015;99:145-8 pubmed publisher
..Transiently expressed dp65 and cp65 up-regulated pro-inflammatory cytokine expression levels in dog and cat, respectively. These findings suggest that dp65 and cp65 play important roles in regulating immune function. ..
Tsuchiya H, Nakano R, Konno T, Okabayashi K, Narita T, Sugiya H. Activation of MEK/ERK pathways through NF-ÎºB activation is involved in interleukin-1Î²-induced cyclooxygenease-2 expression in canine dermal fibroblasts. Vet Immunol Immunopathol. 2015;168:223-32 pubmed publisher
..These findings suggest that stimulation of MEK/ERK signaling pathway by NF-ÎºB activation regulates IL-1Î²-induced COX-2 expression and subsequent prostaglandin E2 release in canine dermal fibroblasts. ..
Seth R, Sun L, Ea C, Chen Z. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell. 2005;122:669-82 pubmed
..The transmembrane domain targets MAVS to the mitochondria, implicating a new role of mitochondria in innate immunity...
Montaseri A, Büsch F, Mobasheri A, Buhrmann C, Aldinger C, Rad J, et al
. IGF-1 and PDGF-bb suppress IL-1Î²-induced cartilage degradation through down-regulation of NF-ÎºB signaling: involvement of Src/PI-3K/AKT pathway. PLoS ONE. 2011;6:e28663 pubmed publisher
Okanishi H, Hayashi K, Sakamoto Y, Sano T, Maruyama H, Kagawa Y, et al
. NOD2 mRNA expression and NFkappaB activation in dogs with lymphocytic plasmacytic colitis. J Vet Intern Med. 2013;27:439-44 pubmed publisher
..NOD2 mRNA and NFkappaB activity were significantly higher in the inflamed colon of dogs with LPC, as compared with healthy controls. Our data suggest that NOD2 and NFkappaB play an important role in the pathogenesis of LPC. ..
Okanishi H, Kabeya H, Maruyama S, Kagawa Y, Watari T. Activation of nuclear factor-kappa B and cell adhesion molecule mRNA expression in duodenal mucosa of dogs with lymphocytic-plasmacytic enteritis. Vet Immunol Immunopathol. 2013;154:145-52 pubmed publisher
..However, there was no significant difference in the mRNA levels for TNF?, IL1? and NOD2 between the two groups. These results suggest that NFkappaB and CAMs may play important roles in the pathogenesis of canine LPE. ..
Pei Z, Wang J. Propofol attenuates LPS-induced tumor necrosis factor-Î±, interleukin-6 and nitric oxide expression in canine peripheral blood mononuclear cells possibly through down-regulation of nuclear factor (NF)-ÎºB activation. J Vet Med Sci. 2015;77:139-45 pubmed publisher
..This suggests that non-cytotoxic levels of propofol pretreatment can down-regulate LPS-induced inflammatory responses in canine PBMCs, possibly by inhibiting the nuclear translocation of the NF-ÎºB p65 protein. ..