Gene Symbol: NECTIN4
Description: nectin cell adhesion molecule 4
Alias: nectin-4, nectin-4, nectin 4
Pratakpiriya W, Seki F, Otsuki N, Sakai K, Fukuhara H, Katamoto H, et al
. Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence. J Virol. 2012;86:10207-10 pubmed publisher
..Wild-type CDV strains showed efficient replication with syncytia in Vero cells expressing dog nectin4, and the infection was blocked by an anti-nectin4 antibody...
Otsuki N, Sekizuka T, Seki F, Sakai K, Kubota T, Nakatsu Y, et al
. Canine distemper virus with the intact C protein has the potential to replicate in human epithelial cells by using human nectin4 as a receptor. Virology. 2013;435:485-92 pubmed publisher
..CDV uses SLAM and nectin4 as receptors to replicate in susceptible animals...
Noyce R, Delpeut S, Richardson C. Dog nectin-4 is an epithelial cell receptor for canine distemper virus that facilitates virus entry and syncytia formation. Virology. 2013;436:210-20 pubmed publisher
..Finally, dog nectin-4 also promotes syncytia formation, which could be inhibited by siRNA treatment. These data confirm that dog nectin-4 can be used by CDV to gain entry into epithelial cells, and facilitate virus spread...
Melia M, Earle J, Abdullah H, Reaney K, Tangy F, Cosby S. Use of SLAM and PVRL4 and identification of pro-HB-EGF as cell entry receptors for wild type phocine distemper virus. PLoS ONE. 2014;9:e106281 pubmed publisher
..More recently poliovirus like receptor 4 (PVRL4), also known as nectin 4, has been identified as a receptor for MV, CDV and PPRV on the basolateral surface of polarised epithelial cells...
Delpeut S, Noyce R, Richardson C. The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread. Virology. 2014;454-455:109-17 pubmed publisher
..Furthermore, four key amino acid residues within the V domain of dog PVRL4 and two within the CDV hemagglutinin were shown to be essential for receptor-mediated virus entry. ..
Ader Ebert N, Khosravi M, Herren M, Avila M, Alves L, Bringolf F, et al
. Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process. PLoS Pathog. 2015;11:e1004880 pubmed publisher
..Overall, our study reveals essential mechanistic requirements governing the activation of the morbillivirus membrane fusion cascade and spotlights the H-stalk "spacer" microdomain as a possible drug target for antiviral therapy. ..