MMP9

Summary

Gene Symbol: MMP9
Description: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Alias: 92 kDa gelatinase, 92 kDa type IV collagenase, GELB, MMP-9, gelatinase B, matrix metalloproteinase 9, matrix metalloproteinase-9
Species: dog

Publications

  1. Dog mast cell alpha-chymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain
    K C Fang
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0911, USA
    J Biol Chem 272:25628-35
  2. Matrix metalloproteinase-9/tissue inhibitors of metalloproteinase-1 expression and atrial structural remodeling in a dog model of atrial fibrillation: inhibition with angiotensin-converting enzyme
    Wei Zhang
    Department of Cardiology, Qilu Hospital of Shandong University, Ji nan 250012, PR China
    Cardiovasc Pathol 17:399-409
  3. Canine stem cell factor augments expression of matrix metalloproteinase-9 by CD34 cells
    L K Ostronoff
    Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    Cytotherapy 10:193-202
  4. Severity dependent increases in circulating cardiac troponin I and MMP-9 concentrations after experimental acute pulmonary thromboembolism
    Juliana A Uzuelli
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 388:184-8
  5. Changes to plasminogen activators and matrix metalloproteinase-9 in dogs with toxocarosis
    S C Lai
    Department of Parasitology, Chung Shan Medical University, 110 Section 1, Chien Kuo North Road, Taichung 402, Taiwan
    Vet Parasitol 150:122-7
  6. Matrix metalloproteinase-9 may play a role in recanalization and recurrence after therapeutic embolization of aneurysms or arteries
    Fatiha Bouzeghrane
    Interventional Neuroradiology Research Laboratory, Centre Hospitalier de l Université de Montréal Research Center, Nôtre Dame Hospital, Montreal, Quebec
    J Vasc Interv Radiol 18:1271-9
  7. Effects of treatment with polysulfated glycosaminoglycan on serum cartilage oligomeric matrix protein and C-reactive protein concentrations, serum matrix metalloproteinase-2 and -9 activities, and lameness in dogs with osteoarthritis
    Makoto Fujiki
    Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
    Am J Vet Res 68:827-33
  8. Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ)
    Kazuhiro Fukushima
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    BMC Musculoskelet Disord 8:54
  9. Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease
    Jonathan M Levine
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Am J Vet Res 67:283-7
  10. High expression of 92 kDa type IV collagenase (matrix metalloproteinase-9) in canine mammary adenocarcinoma
    H Yokota
    Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Biochim Biophys Acta 1568:7-12

Scientific Experts

  • H Yokota
  • S E Campbell
  • Kenneth C Fang
  • P C Shih
  • Hideho Ueda
  • Wei Zhang
  • Marcin Nowak
  • Juliana A Uzuelli
  • L K Ostronoff
  • S C Lai
  • Fatiha Bouzeghrane
  • Kazuhiro Fukushima
  • Makoto Fujiki
  • Jonathan M Levine
  • Marzena Podhorska-Okolow
  • Yun Zhang
  • Gui rong Yang
  • Jose E Tanus Santos
  • H-J Kolb
  • C Tejero
  • Piotr Dziegiel
  • Carlos A C Dias-Junior
  • Marzena Podhorska Okolow
  • Janusz A Madej
  • J Mysliwietz
  • Ming Zhong
  • Zhihao Wang
  • H J Kolb
  • Jian Ping Li
  • E Kremmer
  • Chenhong Guo
  • Jose E Tanus-Santos
  • Carlos A C Dias Junior
  • Joe Shineha
  • Christelle Ogoudikpe
  • Kazuhiro Misumi
  • Akinori Nakamura
  • Shu-ichi Ikeda
  • Shu Ichi Ikeda
  • Kazuto Yamanokuchi
  • Jean Raymond
  • Katsutoshi Yuasa
  • Hiroshi Sakamoto
  • K M Chen
  • Igor Salazkin
  • Kunihiro Yoshida
  • Guylaine Gevry
  • Tim Darsaut
  • Craig G Ruaux
  • David A Williams
  • Robert L Bergman
  • Joan R Coates

Detail Information

Publications13

  1. Dog mast cell alpha-chymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain
    K C Fang
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0911, USA
    J Biol Chem 272:25628-35
    ..To obtain a cDNA encoding the complete sequence of mastocytoma gelatinase B, a 2. 3-kilobase clone encoding progelatinase was isolated from a BR mastocytoma library...
  2. Matrix metalloproteinase-9/tissue inhibitors of metalloproteinase-1 expression and atrial structural remodeling in a dog model of atrial fibrillation: inhibition with angiotensin-converting enzyme
    Wei Zhang
    Department of Cardiology, Qilu Hospital of Shandong University, Ji nan 250012, PR China
    Cardiovasc Pathol 17:399-409
    ..Angiotensin-converting enzyme inhibitor treatment may attenuate atrial structural remodeling by normalizing the balance between matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1...
  3. Canine stem cell factor augments expression of matrix metalloproteinase-9 by CD34 cells
    L K Ostronoff
    Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain
    Cytotherapy 10:193-202
    ....
  4. Severity dependent increases in circulating cardiac troponin I and MMP-9 concentrations after experimental acute pulmonary thromboembolism
    Juliana A Uzuelli
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Chim Acta 388:184-8
    ..CONCLUSIONS: Circulating cTnI and pro-MMP-9 increase in proportion to the severity of APT, although the increases in plasma pro-MMP-9 are less clear with less severe APT. These findings may be relevant for clinical APT...
  5. Changes to plasminogen activators and matrix metalloproteinase-9 in dogs with toxocarosis
    S C Lai
    Department of Parasitology, Chung Shan Medical University, 110 Section 1, Chien Kuo North Road, Taichung 402, Taiwan
    Vet Parasitol 150:122-7
    ..However, there was no correlation between inflammation and MMP-2. The use of uPA, tPA or MMP-9 proteolytic enzymes as laboratory reference markers for toxocarosis requires further study...
  6. Matrix metalloproteinase-9 may play a role in recanalization and recurrence after therapeutic embolization of aneurysms or arteries
    Fatiha Bouzeghrane
    Interventional Neuroradiology Research Laboratory, Centre Hospitalier de l Université de Montréal Research Center, Nôtre Dame Hospital, Montreal, Quebec
    J Vasc Interv Radiol 18:1271-9
    ..035). CONCLUSIONS: MMP-9 may play a role in recanalization of arteries after coil occlusion and in recurrences after sponge embolization of aneurysms...
  7. Effects of treatment with polysulfated glycosaminoglycan on serum cartilage oligomeric matrix protein and C-reactive protein concentrations, serum matrix metalloproteinase-2 and -9 activities, and lameness in dogs with osteoarthritis
    Makoto Fujiki
    Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
    Am J Vet Res 68:827-33
    ..Results indicate that decreases in serum COMP concentrations might be related to improvement in lameness after PSGAG treatment...
  8. Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ)
    Kazuhiro Fukushima
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    BMC Musculoskelet Disord 8:54
    ..In contrast, MMP-2, which was activated in the endomysium of groups of regenerating fibers, may be associated with ECM remodeling during muscle regeneration and fiber growth...
  9. Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease
    Jonathan M Levine
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Am J Vet Res 67:283-7
    ..CONCLUSIONS AND CLINICAL RELEVANCE: Data were consistent with results of experimental rodent spinal cord injury studies that indicate that MMP-9 is expressed early during secondary injury...
  10. High expression of 92 kDa type IV collagenase (matrix metalloproteinase-9) in canine mammary adenocarcinoma
    H Yokota
    Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan
    Biochim Biophys Acta 1568:7-12
    ..The results indicated that MMP-9 plays an important role in the progression of a canine mammary tumor and that assay of serum MMP-9 is helpful for early diagnosis as progress of adenocarcinoma...
  11. Molecular cloning and characterization of canine metalloproteinase-9 gene promoter
    S E Campbell
    Department of Clinical Studies, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
    Gene 273:81-7
    ..Promoter deletion studies revealed that regions of promoter were necessary for induction of reporter gene expression...
  12. Expression of extracellular matrix metalloproteinase (MMP-9), E-cadherin and proliferation-associated antigen Ki-67 and their reciprocal correlation in canine mammary adenocarcinomas
    Marcin Nowak
    Department of Pathological Anatomy, Pathophysiology, Microbiology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
    In Vivo 22:463-9
    ..e. in the most frequent histological type of malignant tumour in humans. This may point to suitability of the animal model in studies on mechanism of neoplasia and metastases in humans...