Gene Symbol: MMP13
Description: matrix metallopeptidase 13
Alias: collagenase 3, matrix metalloproteinase-13
Choi E, Lee J, Baek S, Kim S. Gene expression profile altered by orthodontic tooth movement during healing of surgical alveolar defect. Am J Orthod Dentofacial Orthop. 2017;151:1107-1115 pubmed publisher
..The genes participating in high woven-bone fraction in group DT6 could be identified as TNFSF11, MMP13, SPP1, and DMP1, which were verified by quantitative real-time polymerase chain reactions...
Campbell S, Sood A, Argyle D, Nasir L, Argyle S, Bennett D. The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter. Gene. 2002;286:233-40 pubmed
..The canine MMP-13 promoter activity has also been compared to the basal and induced activity of the canine MMP-9, gelatinase B promoter in these cell types. ..
Hellman N, Spector J, Robinson J, Zuo X, Saunier S, Antignac C, et al
. Matrix metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for Madin-Darby canine kidney tubulogenesis. J Biol Chem. 2008;283:4272-82 pubmed
..Of the 19 MMPs and 3 TIMPs present on the Canine Genome 2.0 Array, MMP13 and TIMP1 were up-regulated 198- and 169-fold, respectively, via the MAPK pathway...
Boileau C, Martel Pelletier J, Caron J, Msika P, Guillou G, Baudouin C, et al
. Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13. Arthritis Res Ther. 2009;11:R41 pubmed publisher
..This effect appears to be mediated through the inhibition of inducible nitric oxide synthase and MMP-13, which are key mediators of the structural changes that take place in osteoarthritis. ..