KIT

Summary

Gene Symbol: KIT
Description: KIT proto-oncogene receptor tyrosine kinase
Alias: c-KIT, mast/stem cell growth factor receptor Kit, SCFR, c-KIT gene1, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, receptor tyrosine kinase c-kit, tyrosine-protein kinase Kit
Species: dog
Products:     KIT

Top Publications

  1. Webster J, Kiupel M, Yuzbasiyan Gurkan V. Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors. BMC Cancer. 2006;6:85 pubmed
    Mutations in the c-KIT proto-oncogene have been implicated in the progression of several neoplastic diseases, including gastrointestinal stromal tumors and mastocytosis in humans, and cutaneous mast cell tumors (MCTs) in canines...
  2. Letard S, Yang Y, Hanssens K, Palmerini F, Leventhal P, Guéry S, et al. Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumors. Mol Cancer Res. 2008;6:1137-45 pubmed publisher
    In the current study, we examined the types and frequency of KIT mutations in mast cell tumors from 191 dogs. Sequencing of reverse transcription-PCR products revealed alterations in 50 (26.2%) of the dogs...
  3. Ma Y, Longley B, Wang X, Blount J, Langley K, Caughey G. Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. J Invest Dermatol. 1999;112:165-70 pubmed
    The proto-oncogene c-KIT encodes a growth factor receptor, KIT, with ligand-dependent tyrosine kinase activity that is expressed by several cell types including mast cells...
  4. London C, Galli S, Yuuki T, Hu Z, Helfand S, Geissler E. Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp Hematol. 1999;27:689-97 pubmed
    ..The proto-oncogene c-kit is known to play a critical role in the development and function of mast cells...
  5. Webster J, Yuzbasiyan Gurkan V, Kaneene J, Miller R, Resau J, Kiupel M. The role of c-KIT in tumorigenesis: evaluation in canine cutaneous mast cell tumors. Neoplasia. 2006;8:104-11 pubmed
    The c-KIT proto-oncogene has been implicated in the pathogenesis of several neoplastic diseases, including gastrointestinal stromal tumors and mastocytosis in humans, and mast cell tumors (MCTs) in canines...
  6. Webster J, Yuzbasiyan Gurkan V, Miller R, Kaneene J, Kiupel M. Cellular proliferation in canine cutaneous mast cell tumors: associations with c-KIT and its role in prognostication. Vet Pathol. 2007;44:298-308 pubmed
    ..An additional goal of this study was to evaluate the associations between cellular proliferation and c-KIT mutations and between cellular proliferation and aberrant KIT protein localization in canine MCTs...
  7. Gregory Bryson E, Bartlett E, Kiupel M, Hayes S, Yuzbasiyan Gurkan V. Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11. BMC Cancer. 2010;10:559 pubmed publisher
    ..Little is known about the pathogenesis of these tumors. This study evaluated the role of c-KIT in canine GISTs; specifically, we investigated activating mutations in exons 8, 9, 11, 13, and 17 of c-KIT and ..
  8. Thompson J, Yager J, Best S, Pearl D, Coomber B, Torres R, et al. Canine subcutaneous mast cell tumors: cellular proliferation and KIT expression as prognostic indices. Vet Pathol. 2011;48:169-81 pubmed publisher
    ..The aims of this study were to evaluate the utility of KIT immunohistochemical labeling pattern, c-KIT mutational status (presence of internal tandem duplications in exon 11),..
  9. Giantin M, Aresu L, Aricò A, Gelain M, Riondato F, Comazzi S, et al. Evaluation of tyrosine-kinase receptor c-kit mutations, mRNA and protein expression in canine lymphoma: might c-kit represent a therapeutic target?. Vet Immunol Immunopathol. 2013;154:153-9 pubmed publisher
    c-kit plays an important role in proliferation, survival and differentiation of hematopoietic progenitor cells...

More Information

Publications31

  1. Bush J, Gardiner D, Palmer J, Rajpert De Meyts E, Veeramachaneni D. Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. Int J Androl. 2011;34:e288-95; discussion e295 pubmed publisher
    ..Histopathological and immunohistological analysis of PLAP, KIT, DAZ and DMRT1 expression revealed that canine seminomas closely resemble human spermatocytic seminomas...
  2. Gomes J, Queiroga F, Prada J, Pires I. Study of c-kit immunoexpression in canine cutaneous melanocytic tumors. Melanoma Res. 2012;22:195-201 pubmed publisher
    ..The transmembrane c-kit protein is a receptor tyrosine kinase that is crucial in melanocytic homeostasis and, when mutated, is associated ..
  3. Chen Y, Liao J, Hsu W, Chang S. Identification of the two KIT isoforms and their expression status in canine hemangiosarcomas. BMC Vet Res. 2016;12:142 pubmed publisher
    b>KIT is a tyrosine kinase growth factor receptor. High expression of KIT has been found in several tumors including canine hemangiosarcoma (HSA)...
  4. Takanosu M, Amano S, Kagawa Y. Analysis of c-KIT exon 11 mutations in canine gastrointestinal stromal tumours. Vet J. 2016;207:118-123 pubmed publisher
    The aim of this study was to determine the type and frequency of c-KIT exon 11 mutations in canine gastrointestinal stromal tumours (GISTs) and investigate the association between the c-KIT mutation status and KIT immunohistochemical ..
  5. Gerding W, Akkad D, Epplen J. Spotted Weimaraner dog due to de novo KIT mutation. Anim Genet. 2013;44:605-6 pubmed publisher
  6. Giantin M, Aresu L, Aricò A, Gelain M, Riondato F, Martini V, et al. Evaluation of tyrosine-kinase receptor c-KIT (c-KIT) mutations, mRNA and protein expression in canine leukemia: might c-KIT represent a therapeutic target?. Vet Immunol Immunopathol. 2013;152:325-32 pubmed publisher
    The tyrosine-kinase receptor c-KIT (c-KIT) plays an important role in proliferation, survival and differentiation of progenitor cells in normal hematopoietic cells...
  7. Costa Casagrande T, de Oliveira Barros L, Fukumasu H, Cogliati B, Chaible L, Dagli M, et al. The value of molecular expression of KIT and KIT ligand analysed using real-time polymerase chain reaction and immunohistochemistry as a prognostic indicator for canine cutaneous mast cell tumours. Vet Comp Oncol. 2015;13:1-10 pubmed publisher
    This study investigated the correlation between KIT gene expression determined by immunohistochemistry and real-time polymerase chain reaction (RT-PCR) and the rate of tumour recurrence and tumour-related deaths in dogs affected with ..
  8. Klopfleisch R, Meyer A, Schlieben P, Bondzio A, Weise C, Lenze D, et al. Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes. BMC Vet Res. 2012;8:96 pubmed publisher
    Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor...
  9. Jankovsky J, Newkirk K, Ilha M, Newman S. COX-2 and c-kit expression in canine gliomas. Vet Comp Oncol. 2013;11:63-9 pubmed publisher
    Gliomas are among the most common primary neural tumours of dogs. Cyclooxygenase-2 (COX-2) and c-kit overexpression are associated with increased aggressiveness of gliomas and decreased survival in human beings...
  10. Takeuchi Y, Fujino Y, Watanabe M, Takahashi M, Nakagawa T, Takeuchi A, et al. Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: a retrospective cohort study. Vet J. 2013;196:492-8 pubmed publisher
    ..systems, and to confirm the prognostic significance of internal tandem duplications (ITDs) within exon 11 of the c-kit gene (ITD-Exon11)...
  11. Irie M, Takeuchi Y, Ohtake Y, Suzuki H, Nagata N, Miyoshi T, et al. Imatinib mesylate treatment in a dog with gastrointestinal stromal tumors with a c-kit mutation. J Vet Med Sci. 2015;77:1535-9 pubmed publisher
    ..sequence analysis of cDNA obtained from a biopsy of the recurrent tumors revealed a mutation within exon 9 of the c-kit gene (1523A>T, Asn(508)Ile), which has been shown to cause ligand-independent phosphorylation of the KIT protein ..
  12. London C, Gardner H, Rippy S, Post G, La Perle K, Crew L, et al. KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells. Clin Cancer Res. 2017;23:2565-2574 pubmed publisher
    b>Purpose: KTN0158 is a novel anti-KIT antibody that potently inhibits wild-type and mutant KIT...
  13. Chu P, Pan S, Liu C, Lee J, Yeh L, Liao A. KIT gene exon 11 mutations in canine malignant melanoma. Vet J. 2013;196:226-30 pubmed publisher
    The proto-oncogene KIT encodes a receptor tyrosine kinase which has been shown to be upregulated in canine melanomas. KIT mutations lead to constitutive phosphorylation and activation of KIT in the absence of ligand binding...
  14. Murakami A, Mori T, Sakai H, Murakami M, Yanai T, Hoshino Y, et al. Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas. Vet Comp Oncol. 2011;9:219-24 pubmed publisher
    b>KIT, a transmembrane receptor tyrosine kinase, is one of the specific targets for anti-cancer therapy...
  15. Takeuchi Y, Fujino Y, Fukushima K, Watanabe M, Nakagawa T, Ohno K, et al. Biological effect of tyrosine kinase inhibitors on three canine mast cell tumor cell lines with various KIT statuses. J Vet Pharmacol Ther. 2012;35:97-104 pubmed publisher
    ..effect of four TKIs (axitinib, imatinib, masitinib, and vatalanib) for proliferation and phosphorylation of c-Kit receptor as well as the expression and function of ABCB1 were investigated in three cMCT cell lines (HRMC, VIMC1, ..
  16. Peter B, Hadzijusufovic E, Blatt K, Gleixner K, Pickl W, Thaiwong T, et al. KIT polymorphisms and mutations determine responses of neoplastic mast cells to bafetinib (INNO-406). Exp Hematol. 2010;38:782-91 pubmed publisher
    ..The tyrosine kinase receptor KIT is often mutated and activated and thus contributes to malignant growth of MC...
  17. Amagai Y, Matsuda A, Jung K, Oida K, Jang H, Ishizaka S, et al. A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization. Sci Rep. 2015;5:9775 pubmed publisher
    Mutations in the juxtamembrane and tyrosine kinase domains of the KIT receptor have been implicated in several cancers and are known to promote tumorigenesis...
  18. Fonseca Alves C, Bento D, Torres Neto R, Werner J, Kitchell B, Laufer Amorim R. Ki67/KIT double immunohistochemical staining in cutaneous mast cell tumors from Boxer dogs. Res Vet Sci. 2015;102:122-6 pubmed publisher
    ..Ki67 staining and KIT staining are widely used to predict natural behavior in canine MCT but no previous study has evaluated double ..
  19. Mochizuki H, Thomas R, Moroff S, Breen M. Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade. Chromosome Res. 2017;25:129-143 pubmed publisher
    ..Although activating KIT mutations are present in approximately 20% of canine MCTs, molecular etiology is largely unknown for the majority ..
  20. Schlieben P, Meyer A, Weise C, Bondzio A, Gruber A, Klopfleisch R. Tandem duplication of KIT exon 11 influences the proteome of canine mast cell tumours. J Comp Pathol. 2013;148:318-22 pubmed publisher
    Mutations with permanent activation of the stem cell factor receptor KIT have been identified as one potential cause for canine cutaneous mast cell tumours (MCTs)...
  21. Usher S, Radford A, Villiers E, Blackwood L. RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias. Exp Hematol. 2009;37:65-77 pubmed publisher
    To determine the frequency of FLT3, C-KIT, and RAS mutations in canine leukemia patients...
  22. Passantino L, Passantino G, Cianciotta A, Ribaud M, Lo Presti G, Ranieri G, et al. Expression of proto-oncogene C-kit and correlation with morphological evaluations in canine cutaneous mast cell tumors. Immunopharmacol Immunotoxicol. 2008;30:609-21 pubmed publisher
    ..The proto-oncogene c-kit is known to play a critical role in development and function of mast cells (MC)...