Gene Symbol: HRH2
Description: histamine receptor H2
Alias: H2R, HH2R, histamine H2 receptor, gastric receptor I, histamine receptor subtype H2
Species: dog
Products:     HRH2

Top Publications

  1. Gantz I, Schaffer M, Delvalle J, Logsdon C, Campbell V, Uhler M, et al. Molecular cloning of a gene encoding the histamine H2 receptor. Proc Natl Acad Sci U S A. 1991;88:429-33 pubmed
    ..These data indicate that we have cloned a gene that encodes the H2 subclass of histamine receptors. ..
  2. Gantz I, Delvalle J, Wang L, Tashiro T, Munzert G, Guo Y, et al. Molecular basis for the interaction of histamine with the histamine H2 receptor. J Biol Chem. 1992;267:20840-3 pubmed
  3. Khan I, Lapierre N, Rangachari P. Messenger RNAs for neurokinin and histamine receptor subtypes in isolated canine colonic crypts. J Pharmacol Exp Ther. 1995;272:1285-92 pubmed
    ..Thus these observations provide further evidence for the existence of different receptor subtypes in the canine colon. ..
  4. Fukushima Y, Saitoh T, Anai M, Ogihara T, Inukai K, Funaki M, et al. Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting. Biochim Biophys Acta. 2001;1539:181-91 pubmed
    To determine the presence and functional role of the histamine H2 receptor (H2R) palmitoylation, a receptor with a Cys(305) to Ala (A(305) receptor) mutation was generated...
  5. Asanuma H, Minamino T, Ogai A, Kim J, Asakura M, Komamura K, et al. Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs. J Mol Cell Cardiol. 2006;40:666-74 pubmed
    ..We conclude that the blockade of histamine H(2) receptors mediates improvements in the anaerobic myocardial metabolism, and thus protects against ischemia and reperfusion injury. ..
  6. Takahama H, Asanuma H, Sanada S, Fujita M, Sasaki H, Wakeno M, et al. A histamine H? receptor blocker ameliorates development of heart failure in dogs independently of ?-adrenergic receptor blockade. Basic Res Cardiol. 2010;105:787-94 pubmed publisher
    ..This finding strengthens the rationale for using histamine H? blockers in the treatment of heart failure...