Research TopicsGenomes and Genes | GJA1SummaryGene Symbol: GJA1 Description: gap junction protein alpha 1 Alias: cx43, gap junction alpha-1 protein, gap junction protein, alpha 1, 43kDa (connexin 43) Species: dog Products: GJA1 Top Publications
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Publications
- Li X, Su V, Kurata W, Jin C, Lau A. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43. J Biol Chem. 2008;283:5748-59 pubmedThe degradation of connexin43 (Cx43) has been reported to involve both lysosomal and proteasomal degradation pathways; however, very little is known about the mechanisms regulating these Cx43 degradation pathways...
- Dunn C, Su V, Lau A, Lampe P. Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability. J Biol Chem. 2012;287:2600-7 pubmed publisherThe pore-forming gap junctional protein connexin 43 (Cx43) has a short (1-3 h) half-life in cells in tissue culture and in whole tissues...
- G nczi M, Kov cs M, Sepr nyi G, V gh A. The involvement of gap junctions in the delayed phase of the protection induced by cardiac pacing in dogs. Clin Sci (Lond). 2012;123:39-51 pubmed publisher..in the delayed anti-arrhythmic effect of cardiac pacing, with particular reference to the time-course changes in Cx43 (connexin43) expression both after pacing (4×5 min, at a rate of 240 beats/min) and 24 h later, when the dogs ..
- Dunn C, Lampe P. Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size. J Cell Sci. 2014;127:455-64 pubmed publisher..Phosphorylation of connexin43 (Cx43) affects gap junction assembly, channel gating and turnover...
- Burstein B, Comtois P, Michael G, Nishida K, Villeneuve L, Yeh Y, et al. Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure. Circ Res. 2009;105:1213-22 pubmed publisher..001). CHF did not significantly alter overall atrial connexin (Cx)40 and Cx43 mRNA and protein expression levels, but produced Cx43 dephosphorylation, increased Cx40/Cx43 protein expression ..
- Torres L, Matera J, Vasconcellos C, Avanzo J, Hernandez Blazquez F, Dagli M. Expression of connexins 26 and 43 in canine hyperplastic and neoplastic mammary glands. Vet Pathol. 2005;42:633-41 pubmed
- Rüttinger C, Bergmann M, Fink L, Pesch S, Seitz K, Trautmann A, et al. Expression of connexin 43 in normal canine testes and canine testicular tumors. Histochem Cell Biol. 2008;130:537-48 pubmed publisher..b>Cx43 is known to play a role in the differentiation and proliferation of these cell types...
- Meraviglia V, Azzimato V, Colussi C, Florio M, Binda A, Panariti A, et al. Acetylation mediates Cx43 reduction caused by electrical stimulation. J Mol Cell Cardiol. 2015;87:54-64 pubmed publisher..Field stimulation of HL-1 cardiomyocytes at 0.5 Hz for 24 h significantly reduced connexin43 (Cx43) expression and cell-cell communication...
- Ryu K, Li L, Khrestian C, Matsumoto N, Sahadevan J, Ruehr M, et al. Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmias. Am J Physiol Heart Circ Physiol. 2007;293:H1231-41 pubmed..Tissues from RA sites were subjected to immunostaining and immunoblotting to assess connexin (Cx) 40 and Cx43 distribution and expression...
- Willingham Rocky L, Golding M, Wright J, Kraemer D, Westhusin M, Burghardt R. Cloning of GJA1 (connexin43) and its expression in canine ovarian follicles throughout the estrous cycle. Gene Expr Patterns. 2007;7:66-71 pubmedb>GJA1 (also known as connexin43 or Cx43) is the most abundant gap junction protein in mammalian tissues including the ovary...
- Zhong J, Zhang W, Gao H, Li Y, Zhong M, Li D, et al. Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs. Eur J Heart Fail. 2007;9:23-9 pubmed..Ultrastructural changes in left ventricular tissue were observed by transmission electron microscope. Connexin 43 (Cx43) levels in the left ventricular myocardium were measured by confocal laser microscopy...
- Wang J, Li J, Liu H, Yi S, Su G, Zhang Y, et al. Dynamic alterations of connexin43, matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 during ventricular fibrillation in canine. Mol Cell Biochem. 2014;391:259-66 pubmed publisherThe aim of this study is to investigate the dynamic alterations of cardiac connexin 43 (Cx43), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the setting of different ventricular fibrillation (..
- Poelzing S, Akar F, Baron E, Rosenbaum D. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol. 2004;286:H2001-9 pubmed..Because connexin43 (Cx43) is the principal ventricular gap junction protein, we hypothesized that transmural EP heterogeneities are in part ..