Genomes and Genes
Gene Symbol: CACNA1C
Description: calcium voltage-gated channel subunit alpha1 C
Alias: ICA, voltage-dependent L-type calcium channel subunit alpha-1C, L-type Ca channel alpha 1 subunit, L-type calcium channel CaV1.2, atrium L-type calcium channel, calcium channel, voltage-dependent, L type, alpha 1C subunit
- Nishida K, Fujiki A, Sakamoto T, Iwamoto J, Mizumaki K, Hashimoto N, et al. Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia. J Cardiovasc Electrophysiol. 2007;18:765-72 pubmed..Bepridil reverses the electrophysiological consequences of atrial remodeling to some extent and L-type calcium channel downregulation in a canine model of atrial tachycardia. ..
- Yue L, Melnyk P, Gaspo R, Wang Z, Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res. 1999;84:776-84 pubmed..These observations provide a potential molecular basis for the self-perpetuating nature of AF. ..
- Qi X, Yeh Y, Xiao L, Burstein B, Maguy A, Chartier D, et al. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res. 2008;103:845-54 pubmed publisher..These studies elucidate for the first time the molecular feedback mechanisms underlying arrhythmogenic AT remodeling. ..
- Rich A, Kenyon J, Hume J, Overturf K, Horowitz B, Sanders K. Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells. Am J Physiol. 1993;264:C745-54 pubmed..Furthermore, only a single splice variant (rbc-II) was observed. The results suggest that a single class of dihydropyridine-sensitive calcium channels regulates inward calcium current in canine colonic smooth muscle cells...
- Rosati B, Dun W, Hirose M, Boyden P, McKinnon D. Molecular basis of the T- and L-type Ca2+ currents in canine Purkinje fibres. J Physiol. 2007;579:465-71 pubmed..2, suggests that the Ca(v)1.3 channels make, at most, a minor contribution to the L-type current in canine Purkinje cells. ..