CACNA1C

Summary

Gene Symbol: CACNA1C
Description: calcium voltage-gated channel subunit alpha1 C
Alias: ICA, voltage-dependent L-type calcium channel subunit alpha-1C, L-type Ca channel alpha 1 subunit, L-type calcium channel CaV1.2, atrium L-type calcium channel, calcium channel, voltage-dependent, L type, alpha 1C subunit
Species: dog
Products:     CACNA1C

Top Publications

  1. Nishida K, Fujiki A, Sakamoto T, Iwamoto J, Mizumaki K, Hashimoto N, et al. Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia. J Cardiovasc Electrophysiol. 2007;18:765-72 pubmed
    ..Bepridil reverses the electrophysiological consequences of atrial remodeling to some extent and L-type calcium channel downregulation in a canine model of atrial tachycardia. ..
  2. Yue L, Melnyk P, Gaspo R, Wang Z, Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res. 1999;84:776-84 pubmed
    ..These observations provide a potential molecular basis for the self-perpetuating nature of AF. ..
  3. Qi X, Yeh Y, Xiao L, Burstein B, Maguy A, Chartier D, et al. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res. 2008;103:845-54 pubmed publisher
    ..These studies elucidate for the first time the molecular feedback mechanisms underlying arrhythmogenic AT remodeling. ..
  4. Rich A, Kenyon J, Hume J, Overturf K, Horowitz B, Sanders K. Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells. Am J Physiol. 1993;264:C745-54 pubmed
    ..Furthermore, only a single splice variant (rbc-II) was observed. The results suggest that a single class of dihydropyridine-sensitive calcium channels regulates inward calcium current in canine colonic smooth muscle cells...
  5. Rosati B, Dun W, Hirose M, Boyden P, McKinnon D. Molecular basis of the T- and L-type Ca2+ currents in canine Purkinje fibres. J Physiol. 2007;579:465-71 pubmed
    ..2, suggests that the Ca(v)1.3 channels make, at most, a minor contribution to the L-type current in canine Purkinje cells. ..

Detail Information

Publications5

  1. Nishida K, Fujiki A, Sakamoto T, Iwamoto J, Mizumaki K, Hashimoto N, et al. Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia. J Cardiovasc Electrophysiol. 2007;18:765-72 pubmed
    ..Bepridil reverses the electrophysiological consequences of atrial remodeling to some extent and L-type calcium channel downregulation in a canine model of atrial tachycardia. ..
  2. Yue L, Melnyk P, Gaspo R, Wang Z, Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res. 1999;84:776-84 pubmed
    ..These observations provide a potential molecular basis for the self-perpetuating nature of AF. ..
  3. Qi X, Yeh Y, Xiao L, Burstein B, Maguy A, Chartier D, et al. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res. 2008;103:845-54 pubmed publisher
    ..These studies elucidate for the first time the molecular feedback mechanisms underlying arrhythmogenic AT remodeling. ..
  4. Rich A, Kenyon J, Hume J, Overturf K, Horowitz B, Sanders K. Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells. Am J Physiol. 1993;264:C745-54 pubmed
    ..Furthermore, only a single splice variant (rbc-II) was observed. The results suggest that a single class of dihydropyridine-sensitive calcium channels regulates inward calcium current in canine colonic smooth muscle cells...
  5. Rosati B, Dun W, Hirose M, Boyden P, McKinnon D. Molecular basis of the T- and L-type Ca2+ currents in canine Purkinje fibres. J Physiol. 2007;579:465-71 pubmed
    ..2, suggests that the Ca(v)1.3 channels make, at most, a minor contribution to the L-type current in canine Purkinje cells. ..