flavivirus polyprotein gene
Gene Symbol: flavivirus polyprotein gene
Description: flavivirus polyprotein
Species: Dengue virus 4
Luo D, Xu T, Watson R, Scherer Becker D, Sampath A, Jahnke W, et al
. Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO J. 2008;27:3209-19 pubmed publisher
..They also suggest how NS3 could exert an effect as an RNA-anchoring device and thus participate both in flavivirus RNA replication and assembly...
Toro J, Salgado D, Vega R, Rodríguez J, Rodríguez L, Angel J, et al
. Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent Infections. PLoS ONE. 2016;11:e0161795 pubmed publisher
..These results are important in the search for correlates of protection and for determining the ideal age for vaccinating against dengue. ..
Durbin A, Karron R, Sun W, Vaughn D, Reynolds M, Perreault J, et al
. Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region. Am J Trop Med Hyg. 2001;65:405-13 pubmed
..The low level of reactogenicity and high degree of immunogenicity of this vaccine candidate warrant its further evaluation and its use to create chimeric vaccine viruses expressing the structural genes of dengue virus types 1, 2, and 3...
Luo D, Wei N, Doan D, Paradkar P, Chong Y, Davidson A, et al
. Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications. J Biol Chem. 2010;285:18817-27 pubmed publisher
..Our results indicate that the linker region has evolved to an optimum length to confer flexibility to the NS3 protein that is required both for polyprotein processing and RNA replication...
Dong H, Chang D, Xie X, Toh Y, Chung K, Zou G, et al
. Biochemical and genetic characterization of dengue virus methyltransferase. Virology. 2010;405:568-78 pubmed publisher
Lin S, Zou G, Hsieh S, Qing M, Tsai W, Shi P, et al
. The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry. J Virol. 2011;85:5159-71 pubmed publisher
AlcalÃ¡ A, HernÃ¡ndez Bravo R, Medina F, Coll D, Zambrano J, Del Angel R, et al
. The dengue virus non-structural protein 1 (NS1) is secreted from infected mosquito cells via a non-classical caveolin-1-dependent pathway. J Gen Virol. 2017;98:2088-2099 pubmed publisher
..Finally, proximity ligation assays showed direct interaction between NS1 and CAV1 in infected mosquito cells. These findings are in line with the lipoprotein nature of secreted NS1 and provide new insights into the biology of NS1. ..
Swarbrick C, Basavannacharya C, Chan K, Chan S, Singh D, Wei N, et al
. NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication. Nucleic Acids Res. 2017;45:12904-12920 pubmed publisher
..The functionally critical sequence-specific contacts in NS3 RNA binding groove in subdomain III reveals potentially novel allosteric anti-viral drug targets. ..
Parida P, Yadav R, Sarma K. Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes. Curr Pharm Biotechnol. 2014;15:156-72 pubmed
..Suface and interface residues were observed along with hydrogen and hydrophobic interaction. The conserved residues forming hydrogen interaction of NRBP with DENV1-4 serotypes were found to be GLN 305, SER 363 and GLN 379. ..