Gene Symbol: CMVs2gp2
Description: ORF overlaps the C-terminal portion of the viral RdRp (PMID: 8291242)
Alias: ORF overlaps the C-terminal portion of the viral RdRp (PMID: 8291242), 2b protein
Species: cucumber mosaic cucumovirus

Top Publications

  1. González I, Martínez L, Rakitina D, Lewsey M, Atencio F, Llave C, et al. Cucumber mosaic virus 2b protein subcellular targets and interactions: their significance to RNA silencing suppressor activity. Mol Plant Microbe Interact. 2010;23:294-303 pubmed publisher
    The RNA silencing suppressor activity of the 2b protein of Cucumber mosaic virus (CMV) has been variously attributed to its nuclear targeting, its interaction with and inhibition of Argonaute 1 (AGO1), or its ability to bind small RNAs in ..
  2. Ye J, Qu J, Zhang J, Geng Y, Fang R. A critical domain of the Cucumber mosaic virus 2b protein for RNA silencing suppressor activity. FEBS Lett. 2009;583:101-6 pubmed publisher
    Alignment of Cucumber mosaic virus (CMV) 2b protein sequences from two CMV subgroups revealed two highly variable regions...
  3. Lewsey M, Surette M, Robertson F, Ziebell H, Choi S, Ryu K, et al. The role of the Cucumber mosaic virus 2b protein in viral movement and symptom induction. Mol Plant Microbe Interact. 2009;22:642-54 pubmed publisher
    The Cucumber mosaic virus (CMV) 2b protein is a counter-defense factor and symptom determinant. Conserved domains in the 2b protein sequence were mutated in the 2b gene of strain Fny-CMV...
  4. Sunpapao A, Nakai T, Dong F, Mochizuki T, Ohki S. The 2b protein of cucumber mosaic virus is essential for viral infection of the shoot apical meristem and for efficient invasion of leaf primordia in infected tobacco plants. J Gen Virol. 2009;90:3015-21 pubmed publisher
    It has been reported previously that a 2b protein-defective mutant of the cucumber mosaic virus (CMV) Pepo strain (Delta 2b) induces only mild symptoms in systemically infected tobacco plants...
  5. Takeshita M, Koizumi E, Noguchi M, Sueda K, Shimura H, Ishikawa N, et al. Infection dynamics in viral spread and interference under the synergism between Cucumber mosaic virus and Turnip mosaic virus. Mol Plant Microbe Interact. 2012;25:18-27 pubmed publisher
    ..To dissect the relationships between spatial infection patterns and the 2b protein (2b) of CMV in single or mixed infections, the CMV vectors expressing enhanced green fluorescent or Discosoma sp...
  6. Inaba J, Kim B, Shimura H, Masuta C. Virus-induced necrosis is a consequence of direct protein-protein interaction between a viral RNA-silencing suppressor and a host catalase. Plant Physiol. 2011;156:2026-36 pubmed publisher
    ..The CMV 2b protein (2b), a known RNA-silencing suppressor, is involved in viral movement and symptom induction...
  7. Rizzo T, Palukaitis P. Nucleotide sequence and evolutionary relationships of cucumber mosaic virus (CMV) strains: CMV RNA 2. J Gen Virol. 1988;69 ( Pt 8):1777-87 pubmed
    ..The evolutionary relationships and the divergence and retention of specific sequences among the two CMV strains and other plant viruses are discussed. ..
  8. Praveen S, Mangrauthia S, Singh P, Mishra A. Behavior of RNAi suppressor protein 2b of Cucumber mosaic virus in planta in presence and absence of virus. Virus Genes. 2008;37:96-102 pubmed publisher
    The 2b protein encoded by Cucumber mosaic virus (CMV) has been shown as a virus counter defense factor that interferes with the RNAi pathway...
  9. Ahn J, Yin C, Liu J, Jeong W. Cucumber mosaic virus 2b protein inhibits RNA silencing pathways in green alga Chlamydomonas reinhardtii. Plant Cell Rep. 2010;29:967-75 pubmed publisher
    ..Taken together, our results demonstrate that CMV2b may suppress both siRNA and miRNA pathways, and also impair AGOs and DCL1 expression in C. reinhardtii...

More Information


  1. Ziebell H, Murphy A, Groen S, Tungadi T, Westwood J, Lewsey M, et al. Cucumber mosaic virus and its 2b RNA silencing suppressor modify plant-aphid interactions in tobacco. Sci Rep. 2011;1:187 pubmed publisher
    The cucumber mosaic virus (CMV) 2b protein not only inhibits anti-viral RNA silencing but also quenches transcriptional responses of plant genes to jasmonic acid, a key signalling molecule in defence against insects...
  2. Ziebell H, Carr J. Effects of dicer-like endoribonucleases 2 and 4 on infection of Arabidopsis thaliana by cucumber mosaic virus and a mutant virus lacking the 2b counter-defence protein gene. J Gen Virol. 2009;90:2288-92 pubmed publisher
    ..The results suggest that Fny-CMVDelta2b/Fny-CMV cross-protection is not completely dependent on RNA silencing and also involves competition between these viruses...
  3. Murota K, Shimura H, Takeshita M, Masuta C. Interaction between Cucumber mosaic virus 2b protein and plant catalase induces a specific necrosis in association with proteasome activity. Plant Cell Rep. 2017;36:37-47 pubmed publisher
    Cucumber mosaic virus (CMV) can induce a specific necrosis on Arabidopsis through the interaction between the CMV 2b protein and host catalase, in which the ubiquitin-proteasome pathway may be involved...
  4. Du Z, Chen F, Zhao Z, Liao Q, Palukaitis P, Chen J. The 2b protein and the C-terminus of the 2a protein of cucumber mosaic virus subgroup I strains both play a role in viral RNA accumulation and induction of symptoms. Virology. 2008;380:363-70 pubmed publisher
    ..However, sequence analysis revealed that Leu(55) of the 2b protein was necessary but not sufficient for FCb7(2b)-CMV to induce systemic necrosis...
  5. Wu D, Qi T, Li W, Tian H, Gao H, Wang J, et al. Viral effector protein manipulates host hormone signaling to attract insect vectors. Cell Res. 2017;27:402-415 pubmed publisher
    ..Here we reveal that the aphid-borne cucumber mosaic virus (CMV) employs its 2b protein, a well-characterized viral suppressor of host RNA interference (VSR), to target the host's jasmonate (JA) ..