VEGFA

Summary

Gene Symbol: VEGFA
Description: vascular endothelial growth factor A
Alias: VEGF, VEGF-A, VPF, eVEGF120, eVEGF164, vascular endothelial growth factor 164, vascular permeability factor
Species: cow

Top Publications

  1. pmc Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization
    Li Liu
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Am J Pathol 182:1412-24. 2013
  2. doi Vascular endothelial growth factor regulates germ cell survival during establishment of spermatogenesis in the bovine testis
    Kyle C Caires
    Department of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA
    Reproduction 138:667-77. 2009
  3. doi Advanced glycation end products increase permeability of brain microvascular endothelial cells through reactive oxygen species-induced vascular endothelial growth factor expression
    Yoshimasa Niiya
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Stroke Cerebrovasc Dis 21:293-8. 2012
  4. ncbi Differential effect of follicle-stimulating hormone and estradiol on expressions of vascular endothelial growth factor (VEGF) 120, VEGF164 and their receptors in bovine granulosa cells
    Takashi Shimizu
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan
    J Reprod Dev 53:105-12. 2007
  5. ncbi The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation
    Mélanie Laramée
    Centre de Recherche du Centre Hospitalier de l Université de Montréal Institut du Cancer de Montréal and Département de Médecine de l Université de Montréal, Montreal, Quebec H2L 4M1, Canada
    J Biol Chem 282:7758-69. 2007
  6. ncbi Vascular endothelial growth factor stimulates the primary to secondary follicle transition in bovine follicles in vitro
    M Y Yang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Mol Reprod Dev 74:1095-104. 2007
  7. ncbi Fibroblast growth factor 2 is more dynamic than vascular endothelial growth factor A during the follicle-luteal transition in the cow
    R S Robinson
    Division of Animal Physiology, University of Nottingham, Loughborough, Leics LE12 5RD, United Kingdom
    Biol Reprod 77:28-36. 2007
  8. doi PKCbetaII/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF gene expression
    Marialaura Amadio
    Department of Experimental and Applied Pharmacology, Via Taramelli 14, 27100 Pavia, Italy
    Pharmacol Res 57:60-6. 2008
  9. doi Effect of local neutralization of basic fibroblast growth factor or vascular endothelial growth factor by a specific antibody on the development of the corpus luteum in the cow
    Hiromichi Yamashita
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Mol Reprod Dev 75:1449-56. 2008
  10. doi Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor
    Juan José P Deudero
    Laboratorio de Nefrologia Hipertension, Fundacion Jimenez Diaz Capio, Hospital de la Princesa, Universidad Autonoma de Madrid, 28040 Madrid, Spain
    J Biol Chem 283:11435-44. 2008

Research Grants

  1. MOLECULAR MECHANISMS OF MATRIX GLA PROTEIN
    KRISTINA BOSTROM; Fiscal Year: 2004
  2. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA BOSTROM; Fiscal Year: 2007
  3. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA I BOSTROM; Fiscal Year: 2010

Scientific Experts

  • Sho ichi Yamagishi
  • Robert S Robinson
  • Jane A Leopold
  • K Bostrom
  • Takashi Shimizu
  • Marialaura Amadio
  • D B Campos
  • Carlos Caramelo
  • Francisco R Gonzalez-Pacheco
  • Li Liu
  • Yoshimasa Niiya
  • Yonghong Pang
  • Yukari Tasaki
  • Li Lin
  • Esther S Shao
  • Malika Oubaha
  • Ji Youn Youn
  • Kyle C Caires
  • Jun Cai
  • Hiromichi Yamashita
  • Christian Rask-Madsen
  • Juan José P Deudero
  • Hana Hünigen
  • Mélanie Laramée
  • M Y Yang
  • Fernando Neria
  • Jean Philippe Gratton
  • James Greenaway
  • Paul Eduard Neagoe
  • Daniel H Platt
  • Susana Yagüe
  • Dongming Zhou
  • M Angeles Castilla
  • Bojun Zhao
  • Yingxiao Wang
  • Lucas DeMaio
  • Martine Duval
  • Jean Claude Mamputu
  • Roger Pamphlett
  • Ali Pedram
  • Michael E Boulton
  • Zhijuan Chen
  • Lynn Shaw
  • Xiaoping Qi
  • Layton H Smith
  • Maria B Grant
  • Takeo Abumiya
  • Jun ichi Takino
  • Masayoshi Takeuchi
  • Chunlei Zhang
  • Wangping Yue
  • Hong Chen
  • Chuzhao Lei
  • Juqiang Wang
  • Xianyong Lan
  • Danxia Chen
  • Chuanwen Gu
  • Kiyoshi Okuda
  • Masami Shibaya
  • Ryo Nishimura
  • Tomas J Acosta
  • Hwa Yong Lee
  • Laura Lin
  • Ning Li
  • Jeanene de Avila
  • Weizhuo Xu
  • Hua Cai
  • Derek J McLean
  • Ting Wang
  • Yunping Dai
  • Yucheng Yao
  • Johanna Plendl
  • María Carmen Castellanos
  • Katsuya Kida
  • Bajram Berisha
  • Olalla Calabia
  • Akio Miyamoto
  • Mahtab Bahramsoltani
  • Ruth Fernandez-Sanchez
  • Koumei Shirasuna
  • Dieter Schams
  • Petra Bisplinghoff
  • Francisco Román González-Pacheco
  • Daichi Kamada
  • Motozumi Matsui
  • Silvia Peñate
  • George L King
  • H Yonekura
  • Albert J Wong
  • Raphaelle Stenne

Detail Information

Publications40

  1. pmc Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization
    Li Liu
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Am J Pathol 182:1412-24. 2013
    Although anti-vascular endothelial growth factor (VEGF) treatments reduce pathological neovascularization in the eye and in tumors, the regression is often not sustainable or is incomplete...
  2. doi Vascular endothelial growth factor regulates germ cell survival during establishment of spermatogenesis in the bovine testis
    Kyle C Caires
    Department of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA
    Reproduction 138:667-77. 2009
    Vascular endothelial growth factor-A (VEGFA) is a hypoxia-inducible peptide essential for angiogenesis and targets nonvascular cells in a variety of tissues and cell types...
  3. doi Advanced glycation end products increase permeability of brain microvascular endothelial cells through reactive oxygen species-induced vascular endothelial growth factor expression
    Yoshimasa Niiya
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Stroke Cerebrovasc Dis 21:293-8. 2012
    ..The aim of this study is to reveal the effect of AGEs on permeability of brain microvascular endothelial cells (BMECs) in order to assess its role in diabetic vascular complications...
  4. ncbi Differential effect of follicle-stimulating hormone and estradiol on expressions of vascular endothelial growth factor (VEGF) 120, VEGF164 and their receptors in bovine granulosa cells
    Takashi Shimizu
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan
    J Reprod Dev 53:105-12. 2007
    Vascular endothelial growth factor (VEGF) isoforms (VEGF 120 and VEGF 164) secreted by granulosa cells are involved in thecal angiogenesis during follicular development in the bovine ovary...
  5. ncbi The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation
    Mélanie Laramée
    Centre de Recherche du Centre Hospitalier de l Université de Montréal Institut du Cancer de Montréal and Département de Médecine de l Université de Montréal, Montreal, Quebec H2L 4M1, Canada
    J Biol Chem 282:7758-69. 2007
    Vascular endothelial growth factor (VEGF) is involved in the promotion of endothelial cell proliferation, migration, and capillary formation...
  6. ncbi Vascular endothelial growth factor stimulates the primary to secondary follicle transition in bovine follicles in vitro
    M Y Yang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Mol Reprod Dev 74:1095-104. 2007
    ..To test the hypothesis that vascular endothelial growth factor (VEGF) promotes the primary to secondary follicle transition, pieces of bovine fetal ovarian cortex were cultured with ..
  7. ncbi Fibroblast growth factor 2 is more dynamic than vascular endothelial growth factor A during the follicle-luteal transition in the cow
    R S Robinson
    Division of Animal Physiology, University of Nottingham, Loughborough, Leics LE12 5RD, United Kingdom
    Biol Reprod 77:28-36. 2007
    ..In the present study, we examined the temporal changes in vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) during the ..
  8. doi PKCbetaII/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF gene expression
    Marialaura Amadio
    Department of Experimental and Applied Pharmacology, Via Taramelli 14, 27100 Pavia, Italy
    Pharmacol Res 57:60-6. 2008
    Vascular endothelial growth factor (VEGF)-induced new vessels formation is a key event in diabetic retinopathy, a severe progressive multistage pathology...
  9. doi Effect of local neutralization of basic fibroblast growth factor or vascular endothelial growth factor by a specific antibody on the development of the corpus luteum in the cow
    Hiromichi Yamashita
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Mol Reprod Dev 75:1449-56. 2008
    ..Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are known to stimulate angiogenesis and P synthesis in vitro...
  10. doi Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor
    Juan José P Deudero
    Laboratorio de Nefrologia Hipertension, Fundacion Jimenez Diaz Capio, Hospital de la Princesa, Universidad Autonoma de Madrid, 28040 Madrid, Spain
    J Biol Chem 283:11435-44. 2008
    Transcriptional regulation of vascular endothelial growth factor (VEGF) is critically dependent on hypoxia-inducible factor 1 (HIF-1). However, not only hypoxia, but selected growth factors can induce HIF-1...
  11. pmc Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 28:919-24. 2008
    Vascular endothelial growth factor (VEGF) stimulates proangiogenic signal transduction and cell function in part through activation of protein kinase C (PKC). Our aim was to examine how individual isoforms of PKC affect VEGF action.
  12. doi Vascular dynamics in relation to immunolocalisation of VEGF-A, VEGFR-2 and Ang-2 in the bovine corpus luteum
    Hana Hünigen
    Institute of Veterinary Anatomy, Faculty of Veterinary Medicine, Freie Universitat Berlin, Koserstr 20, D 14195 Berlin, Germany
    Acta Histochem 110:462-72. 2008
    ..were investigated morphometrically in relation to immunolocalisation of vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR-2) and angiopoietin 2 (Ang-2) in the different cell types...
  13. doi DNA methylation changes in cell line from beta-lactoglobulin gene targeted fetus
    Li Lin
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100094, PR China
    Anim Reprod Sci 112:402-8. 2009
    ..We examined DNA methylation of six genes (beta-actin, VEGF, oct4, TERT, H19 and Igf2) and a repetitive sequence art2 in blg(+/-) cell line from beta-lactoglobulin (BLG) gene ..
  14. pmc An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production
    Ji Youn Youn
    Division of Molecular Medicine, Cardiovascular Research Laboratories, Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Circ Res 104:50-9. 2009
    Calpain was recently reported to mediate vascular endothelial growth factor (VEGF)-induced angiogenesis. In the present study, we investigated detailed molecular mechanisms...
  15. pmc Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells
    Esther S Shao
    Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, CA 90095 1679, USA
    Blood 114:2197-206. 2009
    Expression of vascular endothelial growth factor (VEGF) is tightly regulated to achieve normal angiogenesis. The objective was to examine regulation of VEGF by the activin-like kinase receptors (ALKs) ALK1 and ALK5...
  16. doi Phosphorylation of endothelial nitric oxide synthase by atypical PKC zeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro
    Malika Oubaha
    Laboratory of Endothelial Cell Biology, Institut de Recherches Cliniques de Montreal, Universite de Montreal, Montreal, QC, Canada
    Blood 114:3343-51. 2009
    Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine that also increases vascular permeability...
  17. ncbi Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells
    Yukari Tasaki
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okoyama, Japan
    J Reprod Dev 56:223-9. 2010
    Vascular endothelial growth factor (VEGF) is a well known angiogenic factor that has been suggested to play some physiological roles in reproductive organs...
  18. doi Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term
    D B Campos
    Departamento de Cirurgia, Setor de Anatomia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Genet Mol Res 9:309-23. 2010
    ..Placental growth and function depend on the growth of blood vessels; VEGF-A and bFGF are the most important factors controlling neovascularization and vascular permeability in the placenta...
  19. doi The polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle
    Yonghong Pang
    Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A and F University, 712100, Yangling, Shaanxi, China
    Mol Biol Rep 38:755-9. 2011
    PCR-SSCP and DNA sequencing methods were employed to screen the genetic variation of VEGF gene in 671 individuals belonging to three Chinese indigenous cattle breeds including Nanyang, Jiaxian Red and Qinchuan...
  20. ncbi Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2
    Francisco R Gonzalez-Pacheco
    Laboratorio de Nefrologia Hipertension, Instituto de Investigaciones Medicas, Fundacion Jimenez Diaz, Servicio de Immunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Av Reyes Catolicos 2, E 28040 Madrid, Spain
    Am J Physiol Heart Circ Physiol 291:H1395-401. 2006
    ..We have addressed the hypothesis that vascular endothelial growth factor (VEGF) and its receptors are relevant elements in this response...
  21. ncbi Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3
    Daniel H Platt
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    Free Radic Biol Med 39:1353-61. 2005
    Increased expression of vascular endothelial growth factor (VEGF) has been correlated with increased oxidative stress and formation of peroxynitrite in numerous disease conditions, including diabetic microangiopathy, tumor angiogenesis, ..
  22. ncbi Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells
    Martine Duval
    Laboratory of Endothelial Cell Biology, Institut de recherches cliniques de Montreal IRCM, Quebec H2W 1R7, Canada
    J Biol Chem 278:20091-7. 2003
    ..The vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is responsible for the VEGF-stimulated nitric oxide (NO) production from endothelial cells...
  23. ncbi Mutations in the VEGF promoter and ALS in airline pilots: a link?
    Roger Pamphlett
    J Occup Environ Med 44:987. 2002
  24. ncbi Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide
    Ali Pedram
    Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, California 90822, USA
    J Biol Chem 277:44385-98. 2002
    Vascular endothelial cell growth factor (VEGF) was originally described as a potent vascular permeability factor (VPF) that importantly contributes to vascular pathobiology...
  25. ncbi Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide
    Jean Claude Mamputu
    CHUM Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    J Diabetes Complications 16:284-93. 2002
    ..retinopathy include protein kinase C (PKC) activation, oxidative stress, and vascular endothelial growth factor (VEGF) expression...
  26. ncbi Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis
    H Yonekura
    Department of Biochemistry, Kanazawa University School of Medicine, Kanazawa 920 8640, Japan
    J Biol Chem 274:35172-8. 1999
    We have shown previously that vascular endothelial growth factor (VEGF) synthesized by the cellular constituents of small vessels per se, viz...
  27. pmc Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells
    D Gospodarowicz
    Cancer Research Institute, University of California Medical Center, San Francisco 94143
    Proc Natl Acad Sci U S A 86:7311-5. 1989
    ..The release of FSdGF by pituitary cells and its target cell specificity raise the possibility that FSdGF may play a role in angiogenesis...
  28. ncbi Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    N Ferrara
    Department of Pharmacological Sciences, Genentech Inc, South San Francisco, CA 94080
    Biochem Biophys Res Commun 161:851-8. 1989
    ..Microsequencing reveals a unique N-terminal amino acid sequence. On the basis of its apparent target cell selectivity, we propose to name this factor vascular endothelial growth factor (VEGF).
  29. ncbi Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family
    E Tischer
    California Biotechnology Inc, Mountain View 94043
    Biochem Biophys Res Commun 165:1198-206. 1989
    ..chain reaction (PCR) technique, cDNA clones have been isolated encoding bovine vascular endothelial growth factor (VEGF), a mitogen with specificity for vascular endothelial cells...
  30. ncbi Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis
    Jane A Leopold
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:32100-6. 2003
    ..G6PD or increased G6PD expression by adenoviral gene transfer, and we examined vascular endothelial growth factor (VEGF)-stimulated endothelial cell proliferation, migration, and capillary-like tube formation...
  31. ncbi Up-regulation of vascular endothelial growth factor and down-regulation of pigment epithelium-derived factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes
    S Yamagishi
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Int J Tissue React 24:137-42. 2002
    ..messenger ribonucleic acid levels of an endogenous angiogenic stimulator, vascular endothelial growth factor (VEGF)...
  32. ncbi Cyr61 mediates the expression of VEGF, alphav-integrin, and alpha-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells
    Dongming Zhou
    Dept of Anatomy and Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Box 5, Brooklyn, NY 11203 2098, USA
    J Appl Physiol (1985) 98:2344-54. 2005
    ..Cyr61 expression with an adenoviral vector encoding an antisense oligonucleotide reduced mechanical strain-induced VEGF, alpha(v)-integrin, and SM alpha-actin gene expression but had no effect on the myosin heavy chain isoforms SM-1 ..
  33. ncbi Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer
    Paul Eduard Neagoe
    Research Center, Montreal Heart Institute, Department of Pharmacology, Universite de Montreal, 5000 Belanger St, Montreal, Quebec H1T 1C8, Canada
    J Biol Chem 280:9904-12. 2005
    We previously reported that vascular endothelial growth factor (VEGF)-A(165) inflammatory effect is mediated by acute platelet-activating factor synthesis from endothelial cells upon the activation of VEGF receptor-2 (VEGFR-2) and its ..
  34. ncbi Thrombospondin and vascular endothelial growth factor are cyclically expressed in an inverse pattern during bovine ovarian follicle development
    James Greenaway
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Biol Reprod 72:1071-8. 2005
    ..the expression of the antiangiogenic thrombospondin family and proangiogenic vascular endothelial growth factor (VEGF) in various sizes of healthy bovine follicles...
  35. ncbi VEGF increases paracellular transport without altering the solvent-drag reflection coefficient
    Lucas DeMaio
    Department of Biomedical Engineering, The City College of the City University of New York, New York, NY 10031, USA
    Microvasc Res 68:295-302. 2004
    Vascular endothelial growth factor (VEGF) increases microvascular permeability and has been implicated in the development of numerous pathologies including diabetic retinopathy (DR), hypoxia/ischemia, and tumor biology...
  36. ncbi Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2
    Bojun Zhao
    Cell and Molecular Biology Unit, School of Optometry and Vision Sciences and Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Cardiff CF10 3NB, UK
    Microvasc Res 68:239-46. 2004
    ..In this study, retinal microvascular endothelial cells and pericytes were exposed to varying concentrations of VEGF and glucose and PlGF expression measured by RT-PCR and Western blotting...
  37. ncbi Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells
    KRISTINA BOSTROM
    Division of Cardiology, David Geffen School of Medicine, University of California, Box 951679, Rm 47 123 CHS, Los Angeles, CA 90095 1679, USA
    J Biol Chem 279:52904-13. 2004
    ..increased proliferation, migration, tube formation, and increased release of vascular endothelial growth factor-A (VEGF-A) and basic fibroblast growth factor (bFGF)...
  38. ncbi Tumor-induced endothelial cell activation: role of vascular endothelial growth factor
    M Angeles Castilla
    Clínica de la Concepción, Universidad Autonoma de Madrid, Av Reyes Catolicos 2, 28040 Madrid, Spain
    Am J Physiol Cell Physiol 286:C1170-6. 2004
    ..Furthermore, MG63-CM and MG63-CM + CoCl(2), both containing high amounts of vascular endothelial growth factor (VEGF), induced relevant phenotypic changes in EC (all P < 0...
  39. ncbi Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway
    Yingxiao Wang
    Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla 92093 0427, USA
    Am J Physiol Heart Circ Physiol 286:H685-92. 2004
    ..the molecular mechanisms regulating the downstream IkappaB kinase (IKK) pathway in response to shear stress and VEGF. Both shear stress and VEGF induced a transient increase of IKK activity...
  40. ncbi Vascular endothelial growth factor is a secreted angiogenic mitogen
    D W Leung
    Department of Molecular Biology, Genetech, South San Francisco, CA 94080
    Science 246:1306-9. 1989
    Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC)...

Research Grants6

  1. MOLECULAR MECHANISMS OF MATRIX GLA PROTEIN
    KRISTINA BOSTROM; Fiscal Year: 2004
    ..Understanding the molecular mechanisms of MGP will provide information that is widely applicable to the development of vascular disease. ..
  2. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA BOSTROM; Fiscal Year: 2007
    ..Our results will add insight to calcification of vessels and heart valves, a common problem in heart disease. In addition, it may provide information on how to design new treatments for unwanted calcification. ..
  3. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA I BOSTROM; Fiscal Year: 2010
    ..Our results will add insight to calcification of vessels and heart valves, a common problem in heart disease. In addition, it may provide information on how to design new treatments for unwanted calcification. ..