Gene Symbol: TSHB
Description: thyroid stimulating hormone beta
Alias: thyrotropin subunit beta, TSH-B, TSH-beta, thyroid stimulating hormone, beta polypeptide, thyroid-stimulating hormone subunit beta, thyrotropin beta chain, thyrotropin beta subunit
Liao T, Pierce J. The primary structure of bovine thyrotropin. II. The amino acid sequences of the reduced, S-carboxymethyl alpha and beta chains. J Biol Chem. 1971;246:850-65 pubmed
Kaczur V, Puskas L, Nagy Z, Miled N, Rebai A, Juhasz F, et al
. Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin. J Mol Recognit. 2007;20:392-404 pubmed
..This TSH-related increase in TSHR digested forms was further increased by wild-type peptide. We have identified for the first time ADAM10 as the TSHR cleavage enzyme and shown that TSH regulates its activation. ..
Goto Kazeto R, Kazeto Y, Trant J. Molecular cloning, characterization and expression of thyroid-stimulating hormone receptor in channel catfish. Gen Comp Endocrinol. 2009;161:313-9 pubmed publisher
..As in other species, the heterologous gonadotropin, hCG, partially activated the receptor. These results suggested that TSHR plays important roles for gametogenesis rather than embryogenesis. ..
Montesinos M, Nicola J, Nazar M, Peyret V, Lucero A, Pellizas C, et al
. Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels. Mol Cell Endocrinol. 2016;420:105-15 pubmed publisher
Shome B, Liao T, Howard S, Pierce J. The primary structure of bovine thyrotropin. I. Isolation and partial sequences of cyanogen bromide and tryptic peptides. J Biol Chem. 1971;246:833-49 pubmed
Maurer R, Croyle M, Donelson J. The sequence of a cloned cDNA for the beta subunit of bovine thyrotropin predicts a protein containing both NH2-and COOH-terminal extensions. J Biol Chem. 1984;259:5024-7 pubmed
..This cDNA contains 35 nucleotides from the 5' untranslated region of thyrotropin beta subunit mRNA and 60 nucleotides coding for an NH2-terminal precursor segment...
Fairlie W, Stanton P, Hearn M. The disulphide bond structure of thyroid-stimulating hormone beta-subunit. Biochem J. 1996;314 ( Pt 2):449-55 pubmed
..very small quantities are required for proteins containing an extensive number of half-cystine residues such as TSH beta, owing to the combination of the high resolution of the reversed-phase HPLC peptide mapping procedures and the ..