TSFM

Summary

Gene Symbol: TSFM
Description: Ts translation elongation factor, mitochondrial
Alias: elongation factor Ts, mitochondrial, EF-Ts, EF-TsMt
Species: cow
Products:     TSFM

Top Publications

  1. Karring H, Andersen G, Thirup S, Nyborg J, Spremulli L, Clark B. Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes. Biochim Biophys Acta. 2002;1601:172-7 pubmed
    ..78 A, c=128.89 A and beta=96.978 degrees. The crystals of the homologous mitochondrial EF-Tu:EF-Ts complex diffract to 4 A and belong to space group C2 with cell parameters a=157.7 A, b=151.9 A, c=156.9 A, and beta=108.96 degrees. ..
  2. Akama K, Christian B, Jones C, Ueda T, Takeuchi N, Spremulli L. Analysis of the functional consequences of lethal mutations in mitochondrial translational elongation factors. Biochim Biophys Acta. 2010;1802:692-8 pubmed publisher
    ..coli aa-tRNA but completely inactivates EF-Tu(mt) for binding to mitochondrial aa-tRNA. Clearly the R336Q mutation in EF-Tu(mt) has a far more drastic effect on its interaction with mitochondrial aa-tRNAs than bacterial aa-tRNAs. ..
  3. Xin H, Woriax V, Burkhart W, Spremulli L. Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver. J Biol Chem. 1995;270:17243-9 pubmed
    ..coli elongation factor Tu. This complex is active in poly(U)-directed polymerization of phenylalanine. The precursor form is expressed as a 42-kDa protein, which is rapidly degraded in the cell. ..
  4. Jeppesen M, Navratil T, Spremulli L, Nyborg J. Crystal structure of the bovine mitochondrial elongation factor Tu.Ts complex. J Biol Chem. 2005;280:5071-81 pubmed
    ..The structure of the EF-Tumt.Tsmt complex provides new insights into the nucleotide exchange mechanism and provides a framework for explaining much of the mutational data obtained for this complex. ..