transglutaminase 2


Gene Symbol: transglutaminase 2
Description: transglutaminase 2
Alias: protein-glutamine gamma-glutamyltransferase 2, TG(C), TGC, TGase C, TGase-2, tissue transglutaminase, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), transglutaminase C
Species: cow
Products:     transglutaminase 2

Top Publications

  1. Nakanishi K, Nara K, Hagiwara H, Aoyama Y, Ueno H, Hirose S. Cloning and sequence analysis of cDNA clones for bovine aortic-endothelial-cell transglutaminase. Eur J Biochem. 1991;202:15-21 pubmed
    ..Northern-blot analysis of mRNA from retinoid-treated cultured vascular endothelial cells revealed that retinoids were able to induce a large increase in the transglutaminase mRNA levels. ..
  2. Nara K, Nakanishi K, Hagiwara H, Wakita K, Kojima S, Hirose S. Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase. J Biol Chem. 1989;264:19308-12 pubmed
    ..These results suggest that transglutaminase plays important roles in the maintenance of morphology and the control of endothelial cell functions. ..
  3. Johnson K, Terkeltaub R. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. J Biol Chem. 2005;280:15004-12 pubmed
    Chondrocyte maturation to hypertrophy, associated with up-regulated transglutaminase 2 (TG2) expression, mediates not only physiologic growth plate mineralization but also pathologic matrix calcification and dys-regulated matrix repair in ..
  4. Penumatsa K, Toksoz D, Warburton R, Hilmer A, Liu T, Khosla C, et al. Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2014;307:L576-85 pubmed publisher
    We previously reported that transglutaminase 2 (TG2) activity is markedly elevated in lungs of hypoxia-exposed rodent models of pulmonary hypertension (PH)...
  5. Penumatsa K, Abualkhair S, Wei L, Warburton R, Preston I, Hill N, et al. Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells. Cell Signal. 2014;26:2818-25 pubmed publisher
    b>Tissue transglutaminase 2 (TG2) is a multifunctional enzyme that cross-links proteins with monoamines such as serotonin (5-hydroxytryptamine, 5-HT) via a transglutamidation reaction, and is associated with pathophysiologic vascular ..