Gene Symbol: TNNT2
Description: troponin T2, cardiac type
Alias: troponin T, cardiac muscle, cTnT, cardiac muscle troponin T, tnTc
Gusev N, Barskaya N, Verin A, Duzhenkova I, Khuchua Z, Zheltova A. Some properties of cardiac troponin T structure. Biochem J. 1983;213:123-9 pubmed
..The single thiol group of cardiac troponin T is located some 50-70 residues from the N-terminus. The C-terminal sequence of cardiac troponin T is Trp-Lys, i.e. as is the case of skeletal-muscle troponin T. ..
Hinkle A, Goranson A, Butters C, Tobacman L. Roles for the troponin tail domain in thin filament assembly and regulation. A deletional study of cardiac troponin T. J Biol Chem. 1999;274:7157-64 pubmed
Noland T, Raynor R, Kuo J. Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites. J Biol Chem. 1989;264:20778-85 pubmed
Leszyk J, Dumaswala R, Potter J, Gusev N, Verin A, Tobacman L, et al
. Bovine cardiac troponin T: amino acid sequences of the two isoforms. Biochemistry. 1987;26:7035-42 pubmed
Tobacman L, Lin D, Butters C, Landis C, Back N, Pavlov D, et al
. Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy. J Biol Chem. 1999;274:28363-70 pubmed
..Enhancement as well as impairment of contractile protein function is observed, suggesting that TnT, including the troponin tail region, modulates the regulation of cardiac contraction. ..
Schlecht W, Zhou Z, Li K, Rieck D, Ouyang Y, Dong W. FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation. Arch Biochem Biophys. 2014;550-551:1-11 pubmed publisher
..PKC phosphorylations of cTnT were mimicked by glutamate substitution...
Zhang Z, Biesiadecki B, Jin J. Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage. Biochemistry. 2006;45:11681-94 pubmed
..Triton X-100 extraction of cardiac muscle fibers promoted production of the NH2-terminal truncated cardiac TnT (cTnT-ND), indicating a myofibril-associated proteolytic activity...
Merchant S, Wood D, Salzberg S. Unexpected cross-species contamination in genome sequencing projects. Peerj. 2014;2:e675 pubmed publisher
..Our findings illustrate the need to carefully validate findings of anomalous DNA that rely on comparisons to either draft or finished genomes. ..
Jaquet K, Fukunaga K, Miyamoto E, Meyer H. A site phosphorylated in bovine cardiac troponin T by cardiac CaM kinase II. Biochim Biophys Acta. 1995;1248:193-5 pubmed
..Ca2+/Calmodulin-dependent protein kinase II isolated from heart phosphorylates bovine cardiac troponin T present in the holotroponin complex. Thr-190 has been determined as the main phosphorylation site. ..