Gene Symbol: TNF
Description: tumor necrosis factor
Alias: TNF-a, TNF-alpha, TNFa, tumor necrosis factor, cachectin, tumor necrosis factor alpha, tumor necrosis factor ligand superfamily member 2
Species: cow
Products:     TNF

Top Publications

  1. Dietz A, Neibergs H, Womack J, Kehrli M. Rapid communication: single strand conformational polymorphism (SSCP) of bovine tumor necrosis factor alpha. J Anim Sci. 1997;75:2567 pubmed
  2. Konnai S, Usui T, Ikeda M, Kohara J, Hirata T, Okada K, et al. Tumor necrosis factor-alpha genetic polymorphism may contribute to progression of bovine leukemia virus-infection. Microbes Infect. 2006;8:2163-71 pubmed
    In a previous report, we had indicated that in a sheep model, the expression of tumor necrosis factor (TNF)-alpha was closely associated with disease progression in sheep experimentally infected with bovine leukemia virus (BLV)...
  3. Siemieniuch M, Woclawek Potocka I, Deptula K, Okuda K, Skarzynski D. Effects of tumor necrosis factor-alpha and nitric oxide on prostaglandins secretion by the bovine oviduct differ in the isthmus and ampulla and depend on the phase of the estrous cycle. Exp Biol Med (Maywood). 2009;234:1056-66 pubmed publisher
    To determine the possible roles of tumor necrosis factor-alpha (TNFalpha) and nitric oxide (NO) in the bovine oviduct, ampulla and isthmus collected during the estrous cycle were exposed for 18 h to TNFalpha, NO donor (NONOate), NO ..
  4. Voigt H, Lemke A, Mentlein R, Schünke M, Kurz B. Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro. Arthritis Res Ther. 2009;11:R141 pubmed publisher
    ..inflammation appears to be a causative factor for meniscal destruction, we investigated the influence of tumor necrosis factor (TNFalpha) on glycosaminoglycan (GAG) release and aggrecan cleavage in an in vitro model...
  5. Bradford B, Mamedova L, Minton J, Drouillard J, Johnson B. Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle. J Nutr. 2009;139:1451-6 pubmed publisher
    To determine whether inflammation can induce bovine fatty liver, we administered recombinant bovine tumor necrosis factor-alpha (rbTNF) to late-lactation Holstein cows...
  6. Kushibiki S, Hodate K, Shingu H, Obara Y, Touno E, Shinoda M, et al. Metabolic and lactational responses during recombinant bovine tumor necrosis factor-alpha treatment in lactating cows. J Dairy Sci. 2003;86:819-27 pubmed
    This study examined the effects of recombinant bovine tumor necrosis factor-alpha (rbTNF) administration on metabolic and hormonal responses and lactational performance in dairy cows...
  7. Sadri H, Bruckmaier R, Rahmani H, Ghorbani G, Morel I, van Dorland H. Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows. J Anim Physiol Anim Nutr (Berl). 2010;94:e194-202 pubmed publisher
    ..mRNA was quantified by real-time reverse transcription polymerase chain reaction for tumour necrosis factor alpha (TNF?), insulin-independent glucose transporter (GLUT1), insulin-responsive glucose transporter (GLUT4), insulin ..
  8. Hojo T, ODA A, Lee S, Acosta T, Okuda K. Effects of tumor necrosis factor ? and Interferon ? on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum. J Reprod Dev. 2010;56:515-9 pubmed
    ..We previously reported that a treatment combining tumor necrosis factor ? (TNF) and interferon ? (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (..
  9. Anderson H, Rahmutula D, Gardner D. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004;279:963-9 pubmed
    b>Tumor necrosis factor-alpha (TNF-alpha) has been shown to reduce endothelial nitric-oxide synthase (eNOS) gene expression through post-transcriptional regulation of mRNA stability...

More Information


  1. Sohn E, Paape M, Connor E, Bannerman D, Fetterer R, Peters R. Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma. Vet Res. 2007;38:809-18 pubmed
    ..the effects of LPS on the expression of cytokines secreted by bovine PMN, we measured the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-12, and interferon (IFN)-gamma by ELISA after stimulation with ..
  2. Li X, Zhang R, Luo D, Park S, Wang Q, Kim Y, et al. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. J Biol Chem. 2005;280:15061-70 pubmed pivotal component in cell apoptosis and can be activated by a variety of death stimuli including tumor necrosis factor (TNF) alpha and oxidative stress (reactive oxygen species)...
  3. Okuda K, Sakumoto R, Okamoto N, Acosta T, Abe H, Okada H, et al. Cellular localization of genes and proteins for tumor necrosis factor-? (TNF), TNF receptor types I and II in bovine endometrium. Mol Cell Endocrinol. 2010;330:41-8 pubmed publisher
    To determine which cell types produce tumor necrosis factor-? (TNF) and its receptors (TNFRI and TNFRII) in bovine endometrium, we investigated the expression and cellular localization of their mRNAs and proteins...
  4. Kahl S, Elsasser T, Li C. Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers. Domest Anim Endocrinol. 2011;40:213-21 pubmed publisher
    ..Plasma concentrations of the proinflammatory initiation cytokine tumor necrosis factor-? (TNF-?), nitrate+nitrite [NO(x), estimate of nitric oxide (NO) production], haptoglobin (HG; acute phase ..
  5. Bojarojć Nosowicz B, Kaczmarczyk E, Stachura A, Kotkiewicz M. Polymorphism in the promoter region of the tumor necrosis factor-alpha gene in cattle herds naturally infected and uninfected with the bovine leukemia virus. Pol J Vet Sci. 2011;14:671-3 pubmed
    The objective of this study was to describe and compare the genetic structure (TNF-alpha -position 824) of dairy cattle herds infected and not infected with the bovine leukemia virus (BLV)...
  6. Oviedo Boyso J, Cardoso Correa B, Cajero Juárez M, Bravo Patiño A, Valdez Alarcón J, Baizabal Aguirre V. The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta. FEMS Immunol Med Microbiol. 2008;54:53-9 pubmed publisher
    ..aureus is associated with the activation of NF-kappaB and modulated by the proinflammatory cytokines TNF-alpha and IL-1beta. In this work, we explore the ability of BEC to eliminate intracellular S. aureus and S...
  7. Woclawek Potocka I, Kowalczyk Zieba I, Tylingo M, Boruszewska D, Sinderewicz E, Skarzynski D. Effects of lysophopatidic acid on tumor necrosis factor ? and interferon ? action in the bovine corpus luteum. Mol Cell Endocrinol. 2013;377:103-11 pubmed publisher
    We examined the effects of LPA on TNF? and IFN? - induced decrease of P4 synthesis and on the cytokine - induced apoptosis of the cultured luteal cells...
  8. Sakumoto R, Hayashi K, Takahashi T. Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy. Reprod Biol. 2014;14:115-21 pubmed publisher
    ..Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2? receptor (PGFR), tumor necrosis factor-? (TNF) and Fas were found to be higher in the CL of pregnancy than in CL of the cycle...
  9. Cludts I, Cleuter Y, Kettmann R, Burny A, Droogmans L. Cloning and characterization of the tandemly arranged bovine lymphotoxin and tumour necrosis factor-alpha genes. Cytokine. 1993;5:336-41 pubmed
    The screening of a bovine genomic library with a human tumour necrosis factor-alpha (TNF-alpha) cDNA probe resulted in the isolation of a 7.2 kb DNA fragment containing the entire bovine TNF-alpha gene...
  10. Lendez P, Passucci J, Poli M, Gutierrez S, Dolcini G, Ceriani M. Association of TNF-α gene promoter region polymorphisms in bovine leukemia virus (BLV)-infected cattle with different proviral loads. Arch Virol. 2015;160:2001-7 pubmed publisher
    b>Tumor necrosis factor alpha (TNF-α) is a pleiotropic cytokine involved in the immune response against viral and other infections. Its expression levels are affected by a polymorphism in the promoter region of the gene...
  11. Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, et al. Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem. 2005;280:26383-96 pubmed
    ..Dok-4-WT enhanced tumor necrosis factor-alpha (TNF-alpha)-mediated reactive oxygen species (ROS) production, supporting the functional relevance ..
  12. Grosse W, Kappes S, Laegreid W, Keele J, Chitko McKown C, Heaton M. Single nucleotide polymorphism (SNP) discovery and linkage mapping of bovine cytokine genes. Mamm Genome. 1999;10:1062-9 pubmed
    ..Bovine loci for a cluster of IL8 receptors, a stromal cell-derived factor 1, interferon-gamma, and tumor necrosis factor-alpha were mapped at 90, 55, 59, and 34 cM, respectively, from the centromeric ends of the BTA 2, 28, 5, ..
  13. Roy S, Samanta K, Chakraborti T, Chowdhury A, Chakraborti S. Role of TGF-?1 and TNF-? in IL-1? mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease. Arch Biochem Biophys. 2011;513:61-9 pubmed publisher
    We investigated the role of TGF-?1 and TNF-? in mediating the effect of IL-1? in activating proMMP-9 and proMMP-2, and the involvement of an aprotinin sensitive protease in this scenario in bovine pulmonary artery smooth muscle cells...
  14. Elsasser T, Blum J, Kahl S. Characterization of calves exhibiting a novel inheritable TNF-alpha hyperresponsiveness to endotoxin: associations with increased pathophysiological complications. J Appl Physiol (1985). 2005;98:2045-55 pubmed
    ..of calves, herein termed "hyperresponders" (HPR), was identified and defined by the patterns of plasma TNF-alpha concentrations that developed following two challenges with endotoxin (LPS, 0...
  15. Xu G, Li Y, Yang J, Zhou X, Yin X, Liu M, et al. Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages. Mol Cell Biochem. 2007;302:1-7 pubmed
    ..such as MtbPPD, MbPPD, and BCG), followed by real-time RT-PCR assay for the mRNA expression level of TNF-alpha, iNOS, IL-6, and IL-12...
  16. Samavati L, Lee I, Mathes I, Lottspeich F, Huttemann M. Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase. J Biol Chem. 2008;283:21134-44 pubmed publisher
    ..The pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) has been shown to play a central role in inflammation...
  17. Zhang H, Zhang R, Luo Y, D Alessio A, Pober J, Min W. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem. 2004;279:44955-65 pubmed
    ..that ASK-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP protein family, mediates TNF-induced activation of ASK1-JNK signaling pathway...
  18. Abe H, Sakumoto R, Okuda K. Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2α, interferon γ and tumor necrosis factor α. J Reprod Dev. 2015;61:277-86 pubmed publisher
    ..luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells...
  19. Ranjan S, Bhushan B, Panigrahi M, Kumar A, Deb R, Kumar P, et al. Association and expression analysis of single nucleotide polymorphisms of partial tumor necrosis factor alpha gene with mastitis in crossbred cattle. Anim Biotechnol. 2015;26:98-104 pubmed publisher
    A total of 129 crossbred cows were selected to explore the genotypic and expression profiling of partial TNF-α gene and its association with mastitis susceptibility...
  20. Chou W, Yu T, Chen S, Peh H, Liu W, Chen M, et al. TNFalpha-mediated plasminogen activation on neutrophils is involved in the high plasmin activity in mammary secretion of drying-off cows. J Dairy Res. 2009;76:459-68 pubmed publisher
    ..The purposes of the present study were to examine the role of TNF-alpha in polymorphonuclear neutrophil (PMN)-associated Pg activation, and the significance of this activation ..
  21. Konnai S, Usui T, Ikeda M, Kohara J, Hirata T, Okada K, et al. Tumor necrosis factor-alpha up-regulation in spontaneously proliferating cells derived from bovine leukemia virus-infected cattle. Arch Virol. 2006;151:347-60 pubmed
    We previously reported that tumor necrosis factor alpha (TNF-alpha) was one of the cytokines that contributed to the leukemogenesis caused by bovine leukemia virus (BLV)...
  22. Purmessur D, Walter B, Roughley P, Laudier D, Hecht A, Iatridis J. A role for TNF? in intervertebral disc degeneration: a non-recoverable catabolic shift. Biochem Biophys Res Commun. 2013;433:151-6 pubmed publisher
    This study examines the effect of TNF? on whole bovine intervertebral discs in organ culture and its association with changes characteristic of intervertebral disc degeneration (IDD) in order to inform future treatments to mitigate the ..
  23. Yang W, Zerbe H, Petzl W, Brunner R, Günther J, Draing C, et al. Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. Mol Immunol. 2008;45:1385-97 pubmed
    ..Rather, the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder. ..
  24. Oviedo Boyso J, Bravo Patiño A, Cajero Juárez M, Valdez Alarcón J, Baizabal Aguirre V. TNF-alpha reduces the level of Staphylococcus epidermidis internalization by bovine endothelial cells. FEMS Microbiol Lett. 2009;292:92-9 pubmed publisher
    ..plays an important role during inflammation and it is the target of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha)...
  25. Tamura R, Nemoto T, Maruta T, Onizuka S, Yanagita T, Wada A, et al. Up-regulation of NaV1.7 sodium channels expression by tumor necrosis factor-? in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons. Anesth Analg. 2014;118:318-24 pubmed publisher
    b>Tumor necrosis factor-? (TNF-?) is not only a key regulator of inflammatory response but also an important pain modulator...
  26. Correia Álvarez E, Gómez E, Martín D, Carrocera S, Pérez S, Peynot N, et al. Early embryonic and endometrial regulation of tumor necrosis factor and tumor necrosis factor receptor 2 in the cattle uterus. Theriogenology. 2015;83:1028-37 pubmed publisher
    b>Tumor necrosis factor (TNF) alpha likely mediates embryomaternal communication in mammals...
  27. Bojarojć Nosowicz B, Kaczmarczyk E, Stachura A, Kubińska M. Tumor necrosis factor-alpha (TNFα) gene polymorphism and expression of membrane-bound TNFα protein on CD11b+ and IgM+ cells in cows naturally infected with bovine leukemia virus. Pol J Vet Sci. 2015;18:533-9 pubmed publisher
    The aim of this study was to determine whether SNP at position -824 (promoter region) of the TNFα gene significantly differentiates the size of IgM+, CD5+ and CD11b+ cell subpopulations and affects the expression of membrane-bound TNF..
  28. Sakumoto R, Vermehren M, Kenngott R, Okuda K, Sinowatz F. Localization of gene and protein expressions of tumor necrosis factor-{alpha} and tumor necrosis factor receptor types I and II in the bovine corpus luteum during the estrous cycle. J Anim Sci. 2011;89:3040-7 pubmed publisher
    One of the many roles of tumor necrosis factor (TNF)-? is to control mammalian corpus luteum (CL) PG synthesis and apoptotic cell death...
  29. Peli A, Luciani A, De Santis P, Polci A, Britti D. Quantitation of the cytokines TNF-alpha, IL-8 and IL-10 in bovine milk using real-time TaqMan PCR. Vet Res Commun. 2004;28 Suppl 1:359-62 pubmed
  30. Zhang W, Zheng S, Storz P, Min W. Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. J Biol Chem. 2005;280:19036-44 pubmed
    Although both tumor necrosis factor (TNF) and H2O2 induce activation of c-Jun N-terminal kinase (JNK) kinase cascades, it is not known whether they utilize distinct intracellular signaling pathways...
  31. Kawasaki Y, Aoki Y, Magata F, Miyamoto A, Kawashima C, Hojo T, et al. The effect of single nucleotide polymorphisms in the tumor necrosis factor-? gene on reproductive performance and immune function in dairy cattle. J Reprod Dev. 2014;60:173-8 pubmed
    The present study aimed to assess the effect of polymorphisms in the tumor necrosis factor ? (TNF-?) promoter (A/A, A/G and G/G) and exons (T/T, T/C and C/C) on immune function and reproductive performance in dairy cows...
  32. Sui Y, Lee J, DiMicco M, Vanderploeg E, Blake S, Hung H, et al. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum. 2009;60:2985-96 pubmed publisher
    ..The present study was undertaken to study the combined effects of compression injury, tumor necrosis factor alpha (TNFalpha), and interleukin-6 (IL-6) and its soluble receptor (sIL-6R) on immature bovine and adult ..
  33. Ono H, Ichiki T, Ohtsubo H, Fukuyama K, Imayama I, Iino N, et al. CAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells. Hypertens Res. 2006;29:39-47 pubmed
    ..b>Tumor necrosis factor-alpha (TNFalpha) induces endothelial dysfunction and VCAM-1 expression in endothelial cells (ECs)...
  34. Lau A, Kollara A, St John E, Tone A, Virtanen C, Greenblatt E, et al. Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis. Exp Biol Med (Maywood). 2014;239:24-32 pubmed publisher
    ..b>Tumor necrosis factor (TNF) and IL6 levels were also decreased while those of nicotinomide phosphoribosyltransferase (NAMPT) ..
  35. Yuan K, Farney J, Mamedova L, Sordillo L, Bradford B. TNF? altered inflammatory responses, impaired health and productivity, but did not affect glucose or lipid metabolism in early-lactation dairy cows. PLoS ONE. 2013;8:e80316 pubmed publisher
    ..We tested whether administering an inflammatory cytokine, recombinant bovine tumor necrosis factor-? (rbTNF?), affects milk production, metabolism, and health during this period...
  36. Mertens B, Muriuki C, Gaidulis L. Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha. Immunogenetics. 1995;42:430-1 pubmed
  37. Caroprese M, Albenzio M, Annicchiarico G, Sevi A. Changes occurring in immune responsiveness of single- and twin-bearing Comisana ewes during the transition period. J Dairy Sci. 2006;89:562-8 pubmed
    ..In contrast, a relationship was found for the IgG secretions in milk and blood, which suggests that the assessment of humoral immune status may be combined with milking routine in dairy animals. ..
  38. Szóstek A, Lukasik K, Majewska M, Bah M, Znaniecki R, Okuda K, et al. Tumor necrosis factor-? inhibits the stimulatory effect of luteinizing hormone and prostaglandin E(2) on progesterone secretion by the bovine corpus luteum. Domest Anim Endocrinol. 2011;40:183-91 pubmed publisher
    b>Tumor necrosis factor-? (TNF-?) is involved in the tissue remodeling that occurs in the corpus luteum (CL) during its development and regression...
  39. Janowski T, Baranski W, Lukasik K, Skarzynski D, Rudowska M, Zdunczyk S. Prevalence of subclinical endometritis in repeat breeding cows and mRNA expression of tumor necrosis factor alpha and inducible nitric oxide synthase in the endometrium of repeat breeding cows with and without subclinical endometritis. Pol J Vet Sci. 2013;16:693-9 pubmed
    ..a) to evaluate the incidence of this disorder with cytobrush cytology b) to analyze mRNA expression of tumor necrosis factor alpha (TNFalpha) and inducible nitric oxide synthase (iNOS) in endometrial biopsy samples collected from ..
  40. Gilbert S, Duance V, Mason D. Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes. Biochem Soc Trans. 2002;30:886-9 pubmed
  41. Wojdak Maksymiec K, Szyda J, Strabel T. Parity-dependent association between TNF-? and LTF gene polymorphisms and clinical mastitis in dairy cattle. BMC Vet Res. 2013;9:114 pubmed publisher
    ..We proposed tumor necrosis factor ? (TNF-?), lactoferrin (LTF) and macrophage-expressed lysozyme (mLYZ) genes as potential DNA markers in ..
  42. Goodwin B, Pendleton L, Levy M, Solomonson L, Eichler D. Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. Am J Physiol Heart Circ Physiol. 2007;293:H1115-21 pubmed
    Endothelial dysfunction associated with elevated serum levels of TNF-alpha observed in diabetes, obesity, and congenital heart disease results, in part, from the impaired production of endothelial nitric oxide (NO)...
  43. Woclawek Potocka I, Deptula K, Bah M, Lee H, Okuda K, Skarzynski D. Effects of nitric oxide and tumor necrosis factor-alpha on production of prostaglandin F2alpha and E2 in bovine endometrial cells. J Reprod Dev. 2004;50:333-40 pubmed
    The purpose of this study was to determine whether nitric oxide (NO) mediates tumor necrosis factor (TNF)alpha influence on the bovine endometrium. TNFalpha influence on the bovine endometrium is limited to the stromal cells...
  44. Sakumoto R, Shibaya M, Okuda K. Tumor necrosis factor-alpha (TNF alpha) inhibits progesterone and estradiol-17beta production from cultured granulosa cells: presence of TNFalpha receptors in bovine granulosa and theca cells. J Reprod Dev. 2003;49:441-9 pubmed
    The aim of this study was to investigate whether functional tumor necrosis factor-alpha (TNFalpha) receptors are present in the granulosa cells and the cells of theca interna (theca cells), obtained from bovine follicles classified into ..
  45. Moyes K, Drackley J, Morin D, Loor J. Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis. Funct Integr Genomics. 2010;10:53-61 pubmed publisher
    ..ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1, and downregulated genes were HLA-DRA, HLA-A, IRAK1, SOD1, and TNF. Network analysis revealed that TNF was associated with several of the affected genes in NEB cows compared with PEB ..