Gene Symbol: TLR2
Description: toll like receptor 2
Alias: toll-like receptor 2, Toll-like receptor, Toll-like-receptor, exon 1b, Toll-like-receptor, exon 1b_, Toll-like-receptor2, exon 1a, toll-like-receptor 2, exon 1a_
Species: cow
Products:     TLR2

Top Publications

  1. Menzies M, Ingham A. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Vet Immunol Immunopathol. 2006;109:23-30 pubmed publisher
    ..In bovine skin TLRs 2 and 7 were most abundant. In all tissues tested TLR4 expression was at the lower limit of detection...
  2. McGuire K, Jones M, Werling D, Williams J, Glass E, Jann O. Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors. Anim Genet. 2006;37:47-50 pubmed
    ..b>TLR2, TLR3, TLR4, TLR5 and TLR9 map to BTA17, BTA27, BTA8, BTA16 and BTA22 respectively...
  3. Yang W, Zerbe H, Petzl W, Brunner R, Günther J, Draing C, et al. Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. Mol Immunol. 2008;45:1385-97 pubmed
    ..We examined here, if inadequate activation of the bovine TLR2 and TLR4 pathogen receptors by ligands derived from S...
  4. Goldammer T, Zerbe H, Molenaar A, Schuberth H, Brunner R, Kata S, et al. Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Clin Diagn Lab Immunol. 2004;11:174-85 pubmed
    ..information was used to establish real-time PCR quantification assays to measure the mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate ..
  5. Turner M, Cronin J, Healey G, Sheldon I. Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6. Endocrinology. 2014;155:1453-65 pubmed publisher
    ..are commonly found among bacteria and are detected by the Toll-like receptor (TLR) cell surface receptor TLR2 on immune cells...
  6. Chen Y, Oba M, Guan L. Variation of bacterial communities and expression of Toll-like receptor genes in the rumen of steers differing in susceptibility to subacute ruminal acidosis. Vet Microbiol. 2012;159:451-9 pubmed publisher
    ..59, P=0.04), and negatively correlated with total VFA concentration (r=-0.59, P=0.05). The expressions of host TLR2 and 4 genes were significantly higher in AR steers compared to those in AS steers...
  7. Zhang L, Gan Q, Ma T, Li H, Wang X, Li J, et al. Toll-like receptor 2 gene polymorphism and its relationship with SCS in dairy cattle. Anim Biotechnol. 2009;20:87-95 pubmed publisher
    Toll-like receptor 2 (TLR2) plays an important role in the innate immune response to a variety of pathogens. In this study, bovine TLR2 gene was taken as a candidate gene for mastitis resistance...
  8. Moyes K, Drackley J, Morin D, Loor J. Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis. Funct Integr Genomics. 2010;10:53-61 pubmed publisher
    ..Upregulated genes by NEB were ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1, and downregulated genes were HLA-DRA, HLA-A, IRAK1, SOD1, and TNF...
  9. Swain D, Kushwah M, Kaur M, Patbandha T, Mohanty A, Dang A. Formation of NET, phagocytic activity, surface architecture, apoptosis and expression of toll like receptors 2 and 4 (TLR2 and TLR4) in neutrophils of mastitic cows. Vet Res Commun. 2014;38:209-19 pubmed publisher
    ..The study indicated a positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture...

More Information


  1. Ruiz Larra aga O, Manzano C, Iriondo M, Garrido J, Molina E, Vazquez P, et al. Genetic variation of toll-like receptor genes and infection by Mycobacterium avium ssp. paratuberculosis in Holstein-Friesian cattle. J Dairy Sci. 2011;94:3635-41 pubmed publisher
    ..In cattle, 3 members of the TLR family, TLR1, TLR2, and TLR4, are associated with Mycobacterium avium ssp...
  2. Liu Bryan R, Pritzker K, Firestein G, Terkeltaub R. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J Immunol. 2005;174:5016-23 pubmed
    ..We detected TLR2 expression in normal articular chondrocytes and up-regulation of TLR2 in osteoarthritic cartilage chondrocytes in ..
  3. Seabury C, Womack J. Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6. Genomics. 2008;92:235-45 pubmed publisher characterize single-nucleotide polymorphisms (SNPs) and insertion-deletion polymorphisms (indels) within bovine TLR2, TLR6, and PGLYRP1, thereby facilitating future TLR signaling, association, and PGLYRP1 microbicidal assays ..
  4. Farhat K, Riekenberg S, Jung G, Wiesmüller K, Jungi T, Ulmer A. Identification of full length bovine TLR1 and functional characterization of lipopeptide recognition by bovine TLR2/1 heterodimer. Vet Res. 2010;41:34 pubmed publisher
    ..Toll-like receptor 2 (TLR2) recognizes bacterial lipopeptides in a heterodimeric complex with TLR6 or TLR1, thereby discriminating between di- ..
  5. Kwong L, Parsons R, Patterson R, Coffey T, Thonur L, Chang J, et al. Characterisation of antibodies to bovine Toll-like receptor (TLR)-2 and cross-reactivity with ovine TLR2. Vet Immunol Immunopathol. 2011;139:313-8 pubmed publisher involved in the recognition of gram-positive and gram-negative bacteria and heterodimers of TLR1 or TLR6 with TLR2 are crucial for the identification of several PAMPs...
  6. Martins T, Muniz C, Andrade V, Paixão T, Santos R, Borges Ã. Changes in endometrial transcription of TLR2, TLR4, and CD14 during the first-week postpartum in dairy cows with retained placenta. Theriogenology. 2016;85:1282-8 pubmed publisher
    ..Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased (P < 0...
  7. Koets A, Santema W, Mertens H, Oostenrijk D, Keestra M, Overdijk M, et al. Susceptibility to paratuberculosis infection in cattle is associated with single nucleotide polymorphisms in Toll-like receptor 2 which modulate immune responses against Mycobacterium avium subspecies paratuberculosis. Prev Vet Med. 2010;93:305-15 pubmed publisher
    ..To study the role of host genetics in disease susceptibility, the Toll-like receptor 2 (TLR2) gene, selected based on its potential role in immunity to mycobacterial infections, was analyzed for single ..
  8. Yang Z, Fu Y, Gong P, Zheng J, Liu L, Yu Y, et al. Bovine TLR2 and TLR4 mediate Cryptosporidium parvum recognition in bovine intestinal epithelial cells. Microb Pathog. 2015;85:29-34 pubmed publisher
    ..The results showed that bovine intestinal epithelial cells expressed all known TLRs. The expression of TLR2 and TLR4 were up-regulated when bovine intestinal epithelial cells were treated with C. parvum. Meanwhile, C...
  9. Wang Y, Liu S, Li Y, Wang Q, Shao J, Chen Y, et al. Mycoplasma bovis-derived lipid-associated membrane proteins activate IL-1β production through the NF-κB pathway via toll-like receptor 2 and MyD88. Dev Comp Immunol. 2016;55:111-8 pubmed publisher
    ..bovis-derived LAMPs. An NF-κB inhibitor reversed M. bovis-derived LAMP-induced IL-1β expression. TLR2 and myeloid differentiation primary response gene 88 (MyD88) overexpression increased LAMP-dependent IL-1β ..
  10. White S, Kata S, Womack J. Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions. Mamm Genome. 2003;14:149-55 pubmed
    ..panel to map Toll-like receptor 4 (TLR4) to the distal end of bovine Chromosome (Chr) 8, and Toll-like receptor 2 (TLR2) to the proximal end of bovine Chr 17...
  11. Pant S, Schenkel F, Leyva Baca I, Sharma B, Karrow N. Identification of single nucleotide polymorphisms in bovine CARD15 and their associations with health and production traits in Canadian Holsteins. BMC Genomics. 2007;8:421 pubmed
    Toll-like receptor-2 (TLR2) and Caspase Recruitment Domain 15 (CARD15) are important pattern recognition receptors that play a role in the initiation of the inflammatory and subsequent immune response...
  12. Chang G, Xu T, Brand B, Petzl W, Shen X, Seyfert H. Three promoters with different tissue specificity and pathogen inducibility express the toll-like-receptor 2 (TLR2)-encoding gene in cattle. Vet Immunol Immunopathol. 2015;167:57-63 pubmed publisher
    Toll-like-receptor 2 (TLR2) is a dominant receptor for perceiving presence of bacterial pathogens. The promoter controlling its tissue specific and infection induced expression in cattle was unknown...
  13. Zhao Z, Xue Y, Hu Z, Zhou F, Ma B, Long T, et al. Toll-like receptor 2 gene polymorphisms in Chinese Holstein cattle and their associations with bovine tuberculosis. Vet Immunol Immunopathol. 2017;186:51-54 pubmed publisher
    This study evaluated whether there was an association between polymorphisms within the Toll-like receptor 2 gene (TLR2) of Chinese Holstein cattle and susceptibility to bovine tuberculosis (BTB)...
  14. Mucha R, Bhide M, Chakurkar E, Novak M, Mikula I. Toll-like receptors TLR1, TLR2 and TLR4 gene mutations and natural resistance to Mycobacterium avium subsp. paratuberculosis infection in cattle. Vet Immunol Immunopathol. 2009;128:381-8 pubmed publisher
    ..A search was performed for novel mutations in bovine TLR1, TLR2 and TLR4 genes associated with the Mycobacterium avium subsp. paratuberculosis (MAP) infection...
  15. Opsal M, Lien S, Brenna Hansen S, Olsen H, Vage D. Association analysis of the constructed linkage maps covering TLR2 and TLR4 with clinical mastitis in Norwegian Red cattle. J Anim Breed Genet. 2008;125:110-8 pubmed publisher
    ..Previous studies have identified TLR2 and TLR4 as potential candidate genes for disease resistance...
  16. Price J, Bromfield J, Sheldon I. Pathogen-associated molecular patterns initiate inflammation and perturb the endocrine function of bovine granulosa cells from ovarian dominant follicles via TLR2 and TLR4 pathways. Endocrinology. 2013;154:3377-86 pubmed publisher
    ..Cells of the innate immune system use Toll-like receptors TLR2, TLR4, and TLR5 to recognize pathogen-associated molecular patterns (PAMPs) expressed by bacteria, leading to ..
  17. Werling D, Piercy J, Coffey T. Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination?. Vet Immunol Immunopathol. 2006;112:2-11 pubmed
    ..expression of TLR mRNA in bovine antigen-presenting cell subsets, summarise the discovery and the critical roles of TLR2 in host defence against Mycobacteria, and provide evidence for a mycobacteria species-specific response of bovine ..